KALRN and GFI1B

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KALRN	GFI1B
Gene Name		kalirin, RhoGEF kinase	growth factor independent 1B transcription repressor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Actin Cytoskeleton Extracellular Vesicular Exosome	Nucleus Transcription Factor Complex Nuclear Matrix
	Molecular Function	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Metal Ion Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Signal Transduction Small GTPase Mediated Signal Transduction Nervous System Development Axon Guidance Vesicle-mediated Transport Positive Regulation Of Rho GTPase Activity Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Proliferation Chromatin Modification Hemopoiesis Regulation Of Histone H3-K4 Methylation
Pathways		G alpha (q) signalling events Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling EPHB-mediated forward signaling Rho GTPase cycle G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419)
Protein-Protein Interactions		15 interactors: ATXN7 CACNA1A CDC5L COIL DISC1 DTNBP1 EPHB2 FASLG GFI1B LNX1 NDEL1 PAM RAC1 SUMO2 SUMO3	71 interactors: ACTN1 AES AGPAT6 AGRN AJUBA ANKS3 ATXN2 BECN1 BEGAIN BEND5 BRCA1 BRE CCDC136 CCDC85B CENPB CENPJ COPS5 DNAJA3 DTNA DZANK1 EFEMP1 EFEMP2 EGFL7 FBLN1 FBLN5 GRIP2 GRN HECW1 HGS HNRNPK HSPG2 IFFO1 JAG2 KALRN KIF17 LAMB1 LTBP4 LZTS2 MATR3 MEGF6 MEGF8 MID2 MON1A MYH14 NELL1 NELL2 NOTCH1 NSMF PDE4DIP PDLIM5 PDZD4 PHC2 PICK1 PSMA3 RAB11FIP4 RCHY1 RINT1 RNF31 RUNDC3A TAF1 TMF1 TNS2 TRAF1 TRIM27 TRIP6 TSPYL2 TXNDC11 USHBP1 VSNL1 ZNRD1 ZNRF3
Entrez ID		8997	8328
HPRD ID		06859	05088
Ensembl ID		ENSG00000160145	ENSG00000165702
Uniprot IDs		J3QSW6 O60229	Q5VTD9
PDB IDs
Enriched GO Terms of Interacting Partners?		Central Nervous System Neuron Differentiation Central Nervous System Neuron Development Neuron Projection Morphogenesis Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cerebral Cortex Radially Oriented Cell Migration Regulation Of Cell Projection Organization Central Nervous System Neuron Axonogenesis Neuron Development Cellular Chloride Ion Homeostasis Central Nervous System Development Generation Of Neurons Chloride Ion Homeostasis Dendrite Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Cerebral Cortex Cell Migration Neurogenesis Telencephalon Development Positive Regulation Of Proteolysis Neuron Differentiation Telencephalon Cell Migration Forebrain Cell Migration Cell Projection Organization Cell Development Cell Morphogenesis Involved In Differentiation Regulation Of Metabolic Process Regulation Of Cellular Component Organization Brain Development Regulation Of Neuron Projection Development Regulation Of Protein Catabolic Process Head Development Dendrite Development Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Sumoylation Regulation Of Cell Development Positive Regulation Of Cellular Protein Catabolic Process Endomembrane System Organization Regulation Of Axonogenesis Cerebral Cortex Development Forebrain Development Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Signaling Regulation Of Cell Morphogenesis System Development Nervous System Development Positive Regulation Of Cell Development Anatomical Structure Morphogenesis	Regulation Of Cellular Process Cell Communication Regulation Of Cellular Component Organization Regulation Of Signaling Extracellular Matrix Organization Extracellular Structure Organization Signaling Cellular Response To Stimulus Signal Transduction Response To Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Regulation Of Growth Negative Regulation Of Wnt Signaling Pathway Regulation Of Metabolic Process Multicellular Organismal Development Regulation Of Canonical Wnt Signaling Pathway Developmental Process Secretion Negative Regulation Of Signaling Regulation Of Locomotion Cellular Process Regulation Of Cellular Component Movement Focal Adhesion Assembly Protein Localization Protein Ubiquitination Cellular Localization Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Cell-substrate Adhesion Adherens Junction Assembly Cell Differentiation Cellular Component Assembly Neurogenesis Auditory Receptor Cell Fate Commitment Anatomical Structure Development Regulation Of Gene Expression Regulation Of Proteolysis Regulation Of Apoptotic Process Cell-substrate Junction Assembly Regulation Of I-kappaB Kinase/NF-kappaB Signaling Secretion By Cell Regulation Of Cell Proliferation Receptor Clustering Regulation Of Vesicle-mediated Transport
Tagcloud ?		actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 l576 melanomas mined ngs nras pik3r4 ppp6c prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557	appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor rcor1 rcor2 rcor3 repressing restraining sant2 sharp upsurge
Tagcloud (Difference) ?		actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 l576 melanomas mined ngs nras pik3r4 ppp6c prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557	appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor rcor1 rcor2 rcor3 repressing restraining sant2 sharp upsurge
Tagcloud (Intersection) ?