KALRN

Description		kalirin RhoGEF kinase
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Postsynaptic Density Actin Cytoskeleton Extrinsic Component Of Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Nervous System Development Axon Guidance Vesicle-mediated Transport Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction
Pathways		NRAGE signals death through JNK EPHB-mediated forward signaling G alpha (q) signalling events G alpha (12/13) signalling events MAPK6/MAPK4 signaling RHOA GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Acute graft versus host disease in bone marrow transplantation (donor effect) ( 27595289) Amyotrophic lateral sclerosis ( 26580837) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Diffuse large B-cell lymphoma or systemic lupus erythematosus ( 31407831) General cognitive ability ( 29844566) Hematocrit ( 32888494) Heschl's gyrus morphology ( 25130324) Intraocular pressure ( 31959993 29785010 29617998) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Longevity (age >99th survival percentile) ( 31413261) Low urine pH ( 30476138) Lymphocyte count ( 32888494) Marginal zone lymphoma or systemic lupus erythematosus ( 31407831) Mean platelet volume ( 22139419 27863252 32888494) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Monocyte count ( 32888494) Myocardial infarction ( 33532862) Neutrophil percentage of white cells ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Red cell distribution width ( 32888494) Schizophrenia ( 30285260) Stroke ( 32693751) Systolic blood pressure x dichotomous lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373) Thyroid peroxidase antibody levels ( 24586183) Urine pH measurement ( 30476138)
Interacting Genes		22 interacting genes: ATXN7 CACNA1A CDC5L COIL DISC1 DSCAM DSCR9 DTNBP1 ENO3 EPHB2 FASLG GFI1B GRIK1 LNX1 MORC3 NDEL1 NRIP1 PAM PCNT SPTAN1 SUMO2 SUMO3
Entrez ID		8997
HPRD ID		06859
Ensembl ID		ENSG00000160145
Uniprot IDs		A0A804HI91 A0A804HIN3 A0A804HKJ7 A0A804HKT9 C9IZQ6 O60229
PDB IDs		5QQD 5QQE 5QQF 5QQG 5QQH 5QQI 5QQJ 5QQK 5QQL 5QQM 5QQN 5QU9 8C7D
Enriched GO Terms of Interacting Partners?		Hippocampal Mossy Fiber To CA3 Synapse Radial Glia-guided Pyramidal Neuron Migration Regulation Of Dendritic Spine Development Nervous System Development Axon Dendritic Spine Development Regulation Of Synaptic Transmission, Glutamatergic Protein Tag Activity Regulation Of Neuron Projection Development Modulation Of Chemical Synaptic Transmission Cell Projection Morphogenesis Neuron Projection Morphogenesis Microtubule Organizing Center PML Body Cerebral Cortex Radially Oriented Cell Migration Ubiquitin-like Protein Ligase Binding Nuclear Matrix Microtubule Nucleation Cerebral Cortex Cell Migration Regulation Of Axonogenesis Central Nervous System Neuron Axonogenesis Regulation Of Postsynapse Organization Neuronal Cell Body Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Axon Extension Synaptic Transmission, Glutamatergic Neuron Recognition System Development Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Dendritic Spine Morphogenesis Peptidylamidoglycolate Lyase Activity Peptidylglycine Monooxygenase Activity Fatty Acid Primary Amide Biosynthetic Process Cytoskeleton Organization Ovarian Follicle Rupture Telencephalon Cell Migration Forebrain Cell Migration Kinesin Complex Vesicle Transport Along Microtubule Dendrite Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Cellular Response To Amyloid-beta Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Cell Projection Organization Neuron Projection Retraction Negative Regulation Of Glutamate Receptor Signaling Pathway Peptide Amidation
Tagcloud ?