KALRN and EPHB2

Number of citations of the paper that reports this interaction (PMID 12546821)
113

Data Source:
HPRD (in vitro)

		KALRN	EPHB2
Gene Name		kalirin, RhoGEF kinase	EPH receptor B2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Actin Cytoskeleton Extracellular Vesicular Exosome	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Neuronal Cell Body
	Molecular Function	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Metal Ion Binding	Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Receptor Binding Protein Binding ATP Binding Axon Guidance Receptor Activity
	Biological Process	Protein Phosphorylation Signal Transduction Small GTPase Mediated Signal Transduction Nervous System Development Axon Guidance Vesicle-mediated Transport Positive Regulation Of Rho GTPase Activity Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Angiogenesis Urogenital System Development Nervous System Development Axon Guidance Axonal Fasciculation Learning Phosphorylation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Retinal Ganglion Cell Axon Guidance Inner Ear Morphogenesis Ephrin Receptor Signaling Pathway Positive Regulation Of Long-term Neuronal Synaptic Plasticity Camera-type Eye Morphogenesis Negative Regulation Of Axonogenesis Regulation Of Body Fluid Levels Positive Regulation Of Synapse Assembly Palate Development Dendritic Spine Development Dendritic Spine Morphogenesis Commissural Neuron Axon Guidance
Pathways		G alpha (q) signalling events Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling EPHB-mediated forward signaling Rho GTPase cycle G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events	EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling L1CAM interactions
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419)
Protein-Protein Interactions		15 interactors: ATXN7 CACNA1A CDC5L COIL DISC1 DTNBP1 EPHB2 FASLG GFI1B LNX1 NDEL1 PAM RAC1 SUMO2 SUMO3	36 interactors: ABL1 ABL2 ACP1 AQP1 ARHGEF6 BCL2 CRK EFNA5 EFNB1 EFNB2 ERF FOS GRB2 GRIN1 GRIN2B ITSN1 KALRN KSR1 MLLT4 MMP2 MMP9 NCK1 PICK1 PLCG1 PTK2 RASA1 RRAS RYK SDC2 SDCBP SH2D3C SRC SYNJ1 VAV2 VEGFA YES1
Entrez ID		8997	2048
HPRD ID		06859	02997
Ensembl ID		ENSG00000160145	ENSG00000133216
Uniprot IDs		J3QSW6 O60229	P29323
PDB IDs			1B4F 1F0M 2QBX
Enriched GO Terms of Interacting Partners?		Central Nervous System Neuron Differentiation Central Nervous System Neuron Development Neuron Projection Morphogenesis Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cerebral Cortex Radially Oriented Cell Migration Regulation Of Cell Projection Organization Central Nervous System Neuron Axonogenesis Neuron Development Cellular Chloride Ion Homeostasis Central Nervous System Development Generation Of Neurons Chloride Ion Homeostasis Dendrite Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Cerebral Cortex Cell Migration Neurogenesis Telencephalon Development Positive Regulation Of Proteolysis Neuron Differentiation Telencephalon Cell Migration Forebrain Cell Migration Cell Projection Organization Cell Development Cell Morphogenesis Involved In Differentiation Regulation Of Metabolic Process Regulation Of Cellular Component Organization Brain Development Regulation Of Neuron Projection Development Regulation Of Protein Catabolic Process Head Development Dendrite Development Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Sumoylation Regulation Of Cell Development Positive Regulation Of Cellular Protein Catabolic Process Endomembrane System Organization Regulation Of Axonogenesis Cerebral Cortex Development Forebrain Development Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Signaling Regulation Of Cell Morphogenesis System Development Nervous System Development Positive Regulation Of Cell Development Anatomical Structure Morphogenesis	Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Ephrin Receptor Signaling Pathway Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Neuron Development Cell Projection Morphogenesis Cell Projection Organization Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Neuron Differentiation Cell Morphogenesis Response To External Stimulus Generation Of Neurons Cell Development Neurogenesis Locomotion Nervous System Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Signaling Cell Communication Cell Differentiation Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction System Development Regulation Of Signaling Cellular Response To Stimulus Anatomical Structure Development Multicellular Organismal Development Developmental Process Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Response To Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Cell Migration Regulation Of Phosphorus Metabolic Process
Tagcloud ?		actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 l576 melanomas mined ngs nras pik3r4 ppp6c prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557	10a1 10ca1a 3d array beta3 emt ephrin impede inhibits integrin interplay intricate invasion mcf mesenchymal metallo migration mmp9 modulated nmumg nutlin p53 proteinase spheroid tgf transforming transwell verification whereby
Tagcloud (Difference) ?		actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 l576 melanomas mined ngs nras pik3r4 ppp6c prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557	10a1 10ca1a 3d array beta3 emt ephrin impede inhibits integrin interplay intricate invasion mcf mesenchymal metallo migration mmp9 modulated nmumg nutlin p53 proteinase spheroid tgf transforming transwell verification whereby
Tagcloud (Intersection) ?