KALRN and COIL

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KALRN	COIL
Gene Name		kalirin, RhoGEF kinase	coilin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Actin Cytoskeleton Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cajal Body Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Metal Ion Binding	Protein Binding Protein C-terminus Binding Identical Protein Binding
	Biological Process	Protein Phosphorylation Signal Transduction Small GTPase Mediated Signal Transduction Nervous System Development Axon Guidance Vesicle-mediated Transport Positive Regulation Of Rho GTPase Activity Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		G alpha (q) signalling events Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling EPHB-mediated forward signaling Rho GTPase cycle G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419)	Height ( 18391951)
Protein-Protein Interactions		15 interactors: ATXN7 CACNA1A CDC5L COIL DISC1 DTNBP1 EPHB2 FASLG GFI1B LNX1 NDEL1 PAM RAC1 SUMO2 SUMO3	70 interactors: ACTN1 ACTN2 ACTN4 APP ARMCX1 ATXN1 ATXN1L BYSL C1QBP CCDC136 CCDC159 CCNE1 CDC23 CDK2 CEP70 CEP76 CSNK2B CYB5R2 DHX16 DNAJA3 DRG1 FGF12 FHL5 FXR2 GCC1 KALRN KAZN KLC2 KLC4 KLHL42 KLHL8 KPNA3 LNX1 MAD1L1 MFAP1 MYO5B NIF3L1 NOLC1 NUDT18 PDE4D PDLIM5 PIAS4 PICK1 PLEKHG4 POLR2L PREPL PRMT1 PRMT8 PSMA1 PSME3 PTS SART3 SCYL1 SMN1 SNRPB SNRPF SNX6 TAF9 TCAF1 TCEB3B TFCP2 TGS1 TSPYL2 WDR34 WDYHV1 XRCC5 XRCC6 ZBTB25 ZCCHC10 ZNF277
Entrez ID		8997	8161
HPRD ID		06859	02605
Ensembl ID		ENSG00000160145	ENSG00000121058
Uniprot IDs		J3QSW6 O60229	P38432
PDB IDs
Enriched GO Terms of Interacting Partners?		Central Nervous System Neuron Differentiation Central Nervous System Neuron Development Neuron Projection Morphogenesis Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cerebral Cortex Radially Oriented Cell Migration Regulation Of Cell Projection Organization Central Nervous System Neuron Axonogenesis Neuron Development Cellular Chloride Ion Homeostasis Central Nervous System Development Generation Of Neurons Chloride Ion Homeostasis Dendrite Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Cerebral Cortex Cell Migration Neurogenesis Telencephalon Development Positive Regulation Of Proteolysis Neuron Differentiation Telencephalon Cell Migration Forebrain Cell Migration Cell Projection Organization Cell Development Cell Morphogenesis Involved In Differentiation Regulation Of Metabolic Process Regulation Of Cellular Component Organization Brain Development Regulation Of Neuron Projection Development Regulation Of Protein Catabolic Process Head Development Dendrite Development Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Sumoylation Regulation Of Cell Development Positive Regulation Of Cellular Protein Catabolic Process Endomembrane System Organization Regulation Of Axonogenesis Cerebral Cortex Development Forebrain Development Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Signaling Regulation Of Cell Morphogenesis System Development Nervous System Development Positive Regulation Of Cell Development Anatomical Structure Morphogenesis	Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Spliceosomal SnRNP Assembly Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Regulation Of Metabolic Process MRNA Processing Ribonucleoprotein Complex Biogenesis RNA Processing Regulation Of Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Mitotic Cell Cycle RNA Splicing Gene Expression Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Ribonucleoprotein Complex Assembly Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Hyperosmotic Salinity Response Protein Localization To Tight Junction Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of RNA Metabolic Process MRNA Metabolic Process Transcription, DNA-templated Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of Protein Metabolic Process Platelet Degranulation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecular Complex Assembly Negative Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Gene Expression Cellular Response To X-ray Regulation Of Ubiquitin-protein Transferase Activity Viral Process Cellular Component Assembly
Tagcloud ?		actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 l576 melanomas mined ngs nras pik3r4 ppp6c prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557	augment augments bait cbp coactivator coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat stat1 stat2 stat5 stat5b stats yeast
Tagcloud (Difference) ?		actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 l576 melanomas mined ngs nras pik3r4 ppp6c prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557	augment augments bait cbp coactivator coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat stat1 stat2 stat5 stat5b stats yeast
Tagcloud (Intersection) ?