KALRN and ENO3

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		KALRN	ENO3
Description		kalirin RhoGEF kinase	enolase 3
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Postsynaptic Density Actin Cytoskeleton Extrinsic Component Of Membrane Extracellular Exosome	Phosphopyruvate Hydratase Complex Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Magnesium Ion Binding Phosphopyruvate Hydratase Activity Protein Binding Lyase Activity Metal Ion Binding
	Biological Process	Protein Phosphorylation Signal Transduction Nervous System Development Axon Guidance Vesicle-mediated Transport Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction	Gluconeogenesis Glycolytic Process Canonical Glycolysis
Pathways		NRAGE signals death through JNK EPHB-mediated forward signaling G alpha (q) signalling events G alpha (12/13) signalling events MAPK6/MAPK4 signaling RHOA GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle	Glycolysis Gluconeogenesis
Drugs			2-phospho-D-glyceric acid Phosphoenolpyruvate 2-Phosphoglycolic Acid Phosphonoacetohydroxamic Acid
Diseases
GWAS		Acute graft versus host disease in bone marrow transplantation (donor effect) ( 27595289) Amyotrophic lateral sclerosis ( 26580837) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Diffuse large B-cell lymphoma or systemic lupus erythematosus ( 31407831) General cognitive ability ( 29844566) Hematocrit ( 32888494) Heschl's gyrus morphology ( 25130324) Intraocular pressure ( 31959993 29785010 29617998) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Longevity (age >99th survival percentile) ( 31413261) Low urine pH ( 30476138) Lymphocyte count ( 32888494) Marginal zone lymphoma or systemic lupus erythematosus ( 31407831) Mean platelet volume ( 22139419 27863252 32888494) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Monocyte count ( 32888494) Myocardial infarction ( 33532862) Neutrophil percentage of white cells ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Red cell distribution width ( 32888494) Schizophrenia ( 30285260) Stroke ( 32693751) Systolic blood pressure x dichotomous lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373) Thyroid peroxidase antibody levels ( 24586183) Urine pH measurement ( 30476138)	Keratoconus ( 33649486) Red cell distribution width ( 32888494)
Interacting Genes		22 interacting genes: ATXN7 CACNA1A CDC5L COIL DISC1 DSCAM DSCR9 DTNBP1 ENO3 EPHB2 FASLG GFI1B GRIK1 LNX1 MORC3 NDEL1 NRIP1 PAM PCNT SPTAN1 SUMO2 SUMO3	20 interacting genes: ALDOA APP DCTN1 DSP HSPB2 KALRN LINC01554 MAN2A2 MTMR14 NEB PGM1 PKM PNKD SGCG SNAPIN SPTB TCAP TRAPPC2 TRIM63 TTN
Entrez ID		8997	2027
HPRD ID		06859	11746
Ensembl ID		ENSG00000160145	ENSG00000108515
Uniprot IDs		A0A804HI91 A0A804HIN3 A0A804HKJ7 A0A804HKT9 C9IZQ6 O60229	P13929
PDB IDs		5QQD 5QQE 5QQF 5QQG 5QQH 5QQI 5QQJ 5QQK 5QQL 5QQM 5QQN 5QU9 8C7D	2XSX
Enriched GO Terms of Interacting Partners?		Hippocampal Mossy Fiber To CA3 Synapse Radial Glia-guided Pyramidal Neuron Migration Regulation Of Dendritic Spine Development Nervous System Development Axon Dendritic Spine Development Regulation Of Synaptic Transmission, Glutamatergic Protein Tag Activity Regulation Of Neuron Projection Development Modulation Of Chemical Synaptic Transmission Cell Projection Morphogenesis Neuron Projection Morphogenesis Microtubule Organizing Center PML Body Cerebral Cortex Radially Oriented Cell Migration Ubiquitin-like Protein Ligase Binding Nuclear Matrix Microtubule Nucleation Cerebral Cortex Cell Migration Regulation Of Axonogenesis Central Nervous System Neuron Axonogenesis Regulation Of Postsynapse Organization Neuronal Cell Body Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Axon Extension Synaptic Transmission, Glutamatergic Neuron Recognition System Development Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Dendritic Spine Morphogenesis Peptidylamidoglycolate Lyase Activity Peptidylglycine Monooxygenase Activity Fatty Acid Primary Amide Biosynthetic Process Cytoskeleton Organization Ovarian Follicle Rupture Telencephalon Cell Migration Forebrain Cell Migration Kinesin Complex Vesicle Transport Along Microtubule Dendrite Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Cellular Response To Amyloid-beta Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Cell Projection Organization Neuron Projection Retraction Negative Regulation Of Glutamate Receptor Signaling Pathway Peptide Amidation	M Band I Band Titin-telethonin Complex Skeletal Muscle Myosin Thick Filament Assembly Sarcomerogenesis Cytoplasm Somatic Muscle Development Myosin Filament Assembly Actin Cytoskeleton Supramolecular Fiber Organization Z Disc Structural Constituent Of Muscle Skeletal Muscle Thin Filament Assembly Glycolytic Process ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Detection Of Muscle Stretch Hexose Metabolic Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Nucleoside Diphosphate Catabolic Process Cardiac Muscle Tissue Morphogenesis Monosaccharide Metabolic Process Pyruvate Metabolic Process Muscle Contraction Muscle Tissue Morphogenesis Ribonucleoside Diphosphate Metabolic Process Neuron Projection Maintenance Contractile Muscle Fiber Titin Binding Purine Ribonucleotide Catabolic Process Axo-dendritic Transport Striated Muscle Contraction Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process System Process Cardiac Myofibril Assembly Muscle Filament Sliding Actin-myosin Filament Sliding Muscle System Process Actin Filament Organization Nucleotide Catabolic Process Nicotinamide Nucleotide Metabolic Process Carbohydrate Catabolic Process Cardiac Muscle Hypertrophy Ficolin-1-rich Granule Lumen Response To Muscle Stretch Nucleoside Phosphate Catabolic Process Cytosol Muscle Hypertrophy
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