KALRN and PAM

Number of citations of the paper that reports this interaction (PMID 9139723)
24

Data Source:
HPRD (two hybrid)

		KALRN	PAM
Gene Name		kalirin, RhoGEF kinase	peptidylglycine alpha-amidating monooxygenase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Actin Cytoskeleton Extracellular Vesicular Exosome	Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Metal Ion Binding	Peptidylglycine Monooxygenase Activity Peptidylamidoglycolate Lyase Activity Copper Ion Binding Protein Binding Zinc Ion Binding L-ascorbic Acid Binding
	Biological Process	Protein Phosphorylation Signal Transduction Small GTPase Mediated Signal Transduction Nervous System Development Axon Guidance Vesicle-mediated Transport Positive Regulation Of Rho GTPase Activity Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Peptide Amidation Oxidation-reduction Process
Pathways		G alpha (q) signalling events Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling EPHB-mediated forward signaling Rho GTPase cycle G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419)
Protein-Protein Interactions		15 interactors: ATXN7 CACNA1A CDC5L COIL DISC1 DTNBP1 EPHB2 FASLG GFI1B LNX1 NDEL1 PAM RAC1 SUMO2 SUMO3	8 interactors: CALM1 FXYD1 KALRN POMC PRKCA RASSF9 TSC2 UHMK1
Entrez ID		8997	5066
HPRD ID		06859	01361
Ensembl ID		ENSG00000160145	ENSG00000145730
Uniprot IDs		J3QSW6 O60229	P19021
PDB IDs
Enriched GO Terms of Interacting Partners?		Central Nervous System Neuron Differentiation Central Nervous System Neuron Development Neuron Projection Morphogenesis Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cerebral Cortex Radially Oriented Cell Migration Regulation Of Cell Projection Organization Central Nervous System Neuron Axonogenesis Neuron Development Cellular Chloride Ion Homeostasis Central Nervous System Development Generation Of Neurons Chloride Ion Homeostasis Dendrite Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Cerebral Cortex Cell Migration Neurogenesis Telencephalon Development Positive Regulation Of Proteolysis Neuron Differentiation Telencephalon Cell Migration Forebrain Cell Migration Cell Projection Organization Cell Development Cell Morphogenesis Involved In Differentiation Regulation Of Metabolic Process Regulation Of Cellular Component Organization Brain Development Regulation Of Neuron Projection Development Regulation Of Protein Catabolic Process Head Development Dendrite Development Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Sumoylation Regulation Of Cell Development Positive Regulation Of Cellular Protein Catabolic Process Endomembrane System Organization Regulation Of Axonogenesis Cerebral Cortex Development Forebrain Development Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Signaling Regulation Of Cell Morphogenesis System Development Nervous System Development Positive Regulation Of Cell Development Anatomical Structure Morphogenesis	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Heart Contraction Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Rhodopsin Mediated Signaling Pathway Activation Of Adenylate Cyclase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Rhodopsin Mediated Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lyase Activity Response To External Stimulus Activation Of Phospholipase C Activity Negative Regulation Of Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cyclase Activity Positive Regulation Of Hydrolase Activity Regulation Of Cellular Localization Positive Regulation Of CAMP Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Phospholipase Activity Generation Of Precursor Metabolites And Energy Phototransduction, Visible Light Positive Regulation Of Ion Transmembrane Transport Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of MAP Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Phospholipase Activity Regulation Of CAMP Biosynthetic Process Positive Regulation Of Lipase Activity Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Regulation Of CAMP Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Detection Of Light Stimulus
Tagcloud ?		actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 l576 melanomas mined ngs nras pik3r4 ppp6c prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557	affirmative alcohol beneficial challenges college come cons consumption created debate drinking emerging explains face fall harrison held interesting meeting moderate news often physicians problems pros raises royal side won
Tagcloud (Difference) ?		actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 l576 melanomas mined ngs nras pik3r4 ppp6c prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557	affirmative alcohol beneficial challenges college come cons consumption created debate drinking emerging explains face fall harrison held interesting meeting moderate news often physicians problems pros raises royal side won
Tagcloud (Intersection) ?