NRF1 and PARP1

Number of citations of the paper that reports this interaction (PMID 19181665)
9

Data Source:
BioGRID (pull down)

		NRF1	PARP1
Gene Name		nuclear respiratory factor 1	poly (ADP-ribose) polymerase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Extracellular Vesicular Exosome	Nucleus Nuclear Envelope Nucleoplasm Transcription Factor Complex Nucleolus Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription	DNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Identical Protein Binding Poly(A) RNA Binding Protein N-terminus Binding NAD Binding R-SMAD Binding
	Biological Process	Response To Hypoxia Generation Of Precursor Metabolites And Energy Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Organelle Organization Mitochondrion Organization Organ Regeneration Response To Estradiol Response To Lipopolysaccharide Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Folic Acid Response To Electrical Stimulus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Telomere Maintenance DNA Repair Base-excision Repair Double-strand Break Repair Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Protein ADP-ribosylation Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Protein Autoprocessing Signal Transduction Involved In Regulation Of Gene Expression Macrophage Differentiation Cellular Response To Insulin Stimulus Regulation Of Growth Rate DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of SMAD Protein Import Into Nucleus Protein Poly-ADP-ribosylation Cellular Response To Superoxide Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs			Carba-Nicotinamide-Adenine-Dinucleotide NU1025 Nicotinamide 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone 3-Methoxybenzamide 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide 3,4-Dihydro-5-Methyl-Isoquinolinone 2-(3\'-Methoxyphenyl) Benzimidazole-4-Carboxamide 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium trans-4-(7-carbamoyl-1H-benzimidazol-2-yl)-1-propylpiperidinium 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE
Diseases
GWAS		Obesity-related traits ( 23251661)	Melanoma ( 21983785)
Protein-Protein Interactions		10 interactors: CSNK2A1 DYNLL1 FHL2 MAFF PARP1 POGZ PPARGC1A PPRC1 SP4 TRAF2	84 interactors: APLF APTX ATM BCL2 BUB3 CASP1 CASP3 CASP7 CASP8 CD86 CDKN1A CENPA CENPB CREBBP CTSB CTSG E2F1 ERCC6 ERG FOXO1 GTF2F1 GZMB GZMM H2AFY HDAC1 HDAC3 HIST1H1A HIST1H1C HIST1H2BA HIST1H4A HIST1H4C HIST2H2AA3 HMGA1 HOXB7 HSPA2 KAT2B LIG3 LZTR1 MED14 MED6 MYBL2 NCL NCOA6 NEDD8 NFATC1 NFKB1 NPM1 NRF1 PARP2 PARP3 PCNA PIAS4 POLA1 POLA2 POLB POU2F1 PRKDC RARA RBM14 RELA RNF146 RPS3A RXRA SENP1 SENP3 SIRT1 SP1 SREK1 SUMO1 SUMO2 SUPT16H SWAP70 TCF4 TP53 TRIM29 UBE2I UHRF1 WRN XRCC1 XRCC5 XRCC6 ZBTB16 ZBTB9 ZNF423
Entrez ID		4899	142
HPRD ID		02930	01435
Ensembl ID		ENSG00000106459	ENSG00000143799
Uniprot IDs		Q16656 Q96AN2	P09874
PDB IDs			1UK0 1UK1 1WOK 2COK 2CR9 2CS2 2DMJ 2JVN 2L30 2L31 2RCW 2RD6 2RIQ 3GJW 3GN7 3L3L 3L3M 3OD8 3ODA 3ODC 3ODE 4AV1 4DQY 4GV7 4HHY 4HHZ 4L6S
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Response To Reactive Nitrogen Species Nucleobase-containing Compound Metabolic Process Cellular Response To Oxidative Stress Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Nitrite Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Death Response To Oxidative Stress Regulation Of Mitochondrion Organization Cellular Response To Tumor Necrosis Factor Cellular Response To Reactive Oxygen Species Response To Inorganic Substance Positive Regulation Of ATP Biosynthetic Process Positive Regulation Of Mitochondrial DNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Binding Response To Tumor Necrosis Factor Protein Poly-ADP-ribosylation Atrial Cardiac Muscle Cell Development Positive Regulation Of Energy Homeostasis Response To Statin Regulation Of Growth Rate	Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription, DNA-templated DNA Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Chromosome Organization Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process DNA Repair Cellular Response To Stress Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Transcription, DNA-templated Telomere Maintenance Negative Regulation Of Transcription, DNA-templated Viral Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Gene Expression Apoptotic Signaling Pathway Base-excision Repair Regulation Of Apoptotic Process Biosynthetic Process Cellular Response To Stimulus Organelle Organization Response To Stimulus
Tagcloud ?		architectural architecture bach bach1 bach2 bear btb bzip constitutes erythroleukemic globin heterodimer heterodimers holocomplex implicate lcr maf mafk mare mares mel multimeric multivalent nucleoprotein obligate opening poz properly zipper	ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 lig4 mechanistically nhej overhang rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining
Tagcloud (Difference) ?		architectural architecture bach bach1 bach2 bear btb bzip constitutes erythroleukemic globin heterodimer heterodimers holocomplex implicate lcr maf mafk mare mares mel multimeric multivalent nucleoprotein obligate opening poz properly zipper	ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 lig4 mechanistically nhej overhang rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining
Tagcloud (Intersection) ?