NRF1 and ESM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NRF1	ESM1
Description		nuclear respiratory factor 1	endothelial cell specific molecule 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome	Extracellular Region Extracellular Matrix
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity	Hepatocyte Growth Factor Receptor Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Angiogenesis Sprouting Angiogenesis Positive Regulation Of Cell Population Proliferation Positive Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)	Cocaine dependence ( 31212010) Familial squamous cell lung carcinoma ( 29924316) Sense of smell ( 26632684) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)
Interacting Genes		48 interacting genes: AGR2 BBS2 BICRAL BRWD1 C10orf55 C3orf36 CKMT2 COL10A1 CSNK2A1 CSNK2B DYNLL1 ESM1 FHL2 HHIPL1 HIVEP1 KHDC4 KLF15 KPNA5 KRT83 L3MBTL2 L3MBTL3 LHX3 LHX4 LHX6 LMO4 MAFF MVP NDUFAB1 PANX2 PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SLC67A1-AS SP2 SP4 SPMIP10 SPSB2 SRARP TESMIN TOLLIP TRAF2 TRIM35 VEZF1 YPEL3 ZMYM6	16 interacting genes: ADAM12 ANKS1A AQP1 BANP CTNNB1 FAM124B FRS3 HDAC7 HOXA1 ITGB2 MEOX2 NRF1 NUFIP2 PRKAB2 VGLL3 YY1
Entrez ID		4899	11082
HPRD ID		02930	03310
Ensembl ID		ENSG00000106459	ENSG00000164283
Uniprot IDs		Q16656	Q9NQ30
PDB IDs		8K3D 8K4L
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Medial Motor Column Neuron Differentiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Chromatin Zinc Ion Binding Regulation Of Primary Metabolic Process Motor Neuron Axon Guidance Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Spinal Cord Motor Neuron Cell Fate Specification Cell Differentiation In Spinal Cord RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Spinal Cord Association Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Apoptotic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Programmed Cell Death Cell Death Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm	Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Regulation Of Vasculature Development Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Glomerulus Vasculature Development Regulation Of Angiogenesis Eye Morphogenesis Epithelium Development Camera-type Eye Morphogenesis Nitric Oxide Transmembrane Transporter Activity Vasculature Development Metanephric Proximal Convoluted Tubule Segment 2 Development Ephrin Receptor Binding Glycerol Transmembrane Transporter Activity Corticotropin Secretion Mesenchymal Stem Cell Differentiation Nucleoplasm Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Glial Cell Fate Determination Embryonic Pattern Specification Vasculogenesis SMAD Binding Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Protein Kinase Binding Renal Outer Medulla Development Renal Vesicle Formation Fibroblast Growth Factor Receptor Signaling Pathway Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development DNA-binding Transcription Factor Binding Limb Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Integrin AlphaL-beta2 Complex Regulation Of Cell Migration Involved In Sprouting Angiogenesis Immunoglobulin Heavy Chain V-D-J Recombination Sensory Organ Morphogenesis Regulation Of Multicellular Organismal Process Positive Regulation Of Saliva Secretion Nucleus
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