NRF1

Gene Name		nuclear respiratory factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
	Biological Process	Response To Hypoxia Generation Of Precursor Metabolites And Energy Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Organelle Organization Mitochondrion Organization Organ Regeneration Response To Estradiol Response To Lipopolysaccharide Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Folic Acid Response To Electrical Stimulus
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-protein Interactions		10 interactors: CSNK2A1 DYNLL1 FHL2 MAFF PARP1 POGZ PPARGC1A PPRC1 SP4 TRAF2
Entrez ID		4899
HPRD ID		02930
Ensembl ID		ENSG00000106459
Uniprot IDs		Q16656 Q96AN2
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Response To Reactive Nitrogen Species Nucleobase-containing Compound Metabolic Process Cellular Response To Oxidative Stress Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Nitrite Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Death Response To Oxidative Stress Regulation Of Mitochondrion Organization Cellular Response To Tumor Necrosis Factor Cellular Response To Reactive Oxygen Species Response To Inorganic Substance Positive Regulation Of ATP Biosynthetic Process Positive Regulation Of Mitochondrial DNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Binding Response To Tumor Necrosis Factor Protein Poly-ADP-ribosylation Atrial Cardiac Muscle Cell Development Positive Regulation Of Energy Homeostasis Response To Statin Regulation Of Growth Rate
Tagcloud ?		architectural architecture bach bach1 bach2 bear btb bzip constitutes erythroleukemic globin heterodimer heterodimers holocomplex implicate lcr maf mafk mare mares mel multimeric multivalent nucleoprotein obligate opening poz properly zipper