NRF1 and LHX3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NRF1	LHX3
Description		nuclear respiratory factor 1	LIM homeobox 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Motor Neuron Axon Guidance Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Specification Medial Motor Column Neuron Differentiation Spinal Cord Association Neuron Differentiation Pituitary Gland Development Neuron Differentiation Lung Development Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Mitochondrial unfolded protein response (UPRmt)	Regulation of expression of SLITs and ROBOs
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)	Atrial fibrillation ( 30061737) Crohn's disease ( 28067908) Free thyroxine concentration ( 25743335) Height ( 20189936 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) LDL cholesterol levels in HIV infection ( 33109212) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 28166213) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Thyroid hormone levels ( 23408906) Ulcerative colitis ( 28067908)
Interacting Genes		48 interacting genes: AGR2 BBS2 BICRAL BRWD1 C10orf55 C3orf36 CKMT2 COL10A1 CSNK2A1 CSNK2B DYNLL1 ESM1 FHL2 HHIPL1 HIVEP1 KHDC4 KLF15 KPNA5 KRT83 L3MBTL2 L3MBTL3 LHX3 LHX4 LHX6 LMO4 MAFF MVP NDUFAB1 PANX2 PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SLC67A1-AS SP2 SP4 SPMIP10 SPSB2 SRARP TESMIN TOLLIP TRAF2 TRIM35 VEZF1 YPEL3 ZMYM6	80 interacting genes: ABI2 ACTN3 AIF1L ANKRD45 ANP32A ATP6V1G1 BYSL CATSPERT CCDC146 CCDC6 CDC23 CDK3 CITED2 CKS1B CLCNKA CPNE7 CSNK2A1 CWF19L2 DRC4 ENKD1 FAIM FAM124B FAM221A FIGLA GAS2L2 GCM2 GUCD1 HOXC5 HOXC8 IFT172 INCA1 INSC INTS4 IQUB ISL1 ISL2 KANK2 KLHL38 KRT3 LDB1 LDB2 LHX1 LMX1A MAPK9 NFIA NFIB NFIC NFKBID NRDE2 NRF1 NUDT22 OCRL PARP11 PARVG PNMA5 PRKAB2 PSMB1 PSORS1C2 QRICH1 RCOR3 RHBDF1 RLIM RUNX1T1 SAT1 SCNM1 SH2D1A SNRNP25 TAF1 TCEANC TEX14 TSEN54 TSSK3 UBTFL1 USP2 VEZF1 ZNF354C ZNF417 ZNF574 ZNF587 ZNF76
Entrez ID		4899	8022
HPRD ID		02930	02783
Ensembl ID		ENSG00000106459	ENSG00000107187
Uniprot IDs		Q16656	F1T0D5 F1T0D7 F1T0D9 Q9UBR4
PDB IDs		8K3D 8K4L
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Medial Motor Column Neuron Differentiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Chromatin Zinc Ion Binding Regulation Of Primary Metabolic Process Motor Neuron Axon Guidance Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Spinal Cord Motor Neuron Cell Fate Specification Cell Differentiation In Spinal Cord RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Spinal Cord Association Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Apoptotic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Programmed Cell Death Cell Death Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm	Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II LIM Domain Binding Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Neuron Fate Specification Nucleus Cell Differentiation In Spinal Cord DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Central Nervous System Neuron Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Visceral Motor Neuron Differentiation Sequence-specific Double-stranded DNA Binding Nucleoplasm Transcription Regulator Complex Spinal Cord Motor Neuron Differentiation Cytoskeletal Anchor Activity DNA-templated Transcription RNA Metabolic Process RNA Polymerase I General Transcription Initiation Factor Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Cell Population Proliferation Regulation Of Gene Expression Cyclin Binding Pattern Specification Process Chromatin Positive Regulation Of RNA Biosynthetic Process Cell Fate Specification Positive Regulation Of RNA Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of DNA-templated Transcription Negative Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Axis Specification Glial Cell Fate Specification Actin Filament Positive Regulation Of Smoothened Signaling Pathway Neural Tube Formation Regulation Of Macromolecule Biosynthetic Process Peripheral Nervous System Neuron Development
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