NRF1 and L3MBTL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NRF1	L3MBTL3
Description		nuclear respiratory factor 1	L3MBTL histone methyl-lysine binding protein 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity	Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding Metal Ion Binding Methylation-dependent Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Chromatin Organization Regulation Of DNA-templated Transcription Myeloid Cell Differentiation Macrophage Differentiation Granulocyte Differentiation Erythrocyte Maturation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)	A body shape index ( 34021172) Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874 33547301) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 27680694 31043758) Body mass index ( 25673413) Breast cancer ( 29058716 29059683) Breast cancer (estrogen-receptor negative) ( 29058716) C-reactive protein levels ( 30388399) Chronic kidney disease ( 31152163) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 31562340 18391951 23563607 25282103 28552196 25429064) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 25673412 28552196) Immature fraction of reticulocytes ( 32888494) Influenza A (H1N1) infection ( 26379185) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494 27863252) Mild influenza (H1N1) infection ( 26379185) Multiple sclerosis ( 31604244 27386562) Offspring birth weight ( 31043758) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Spleen volume ( 34128465) Triglyceride levels ( 32203549 32154731) Triglyceride levels in HIV infection ( 33109212) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		48 interacting genes: AGR2 BBS2 BICRAL BRWD1 C10orf55 C3orf36 CKMT2 COL10A1 CSNK2A1 CSNK2B DYNLL1 ESM1 FHL2 HHIPL1 HIVEP1 KHDC4 KLF15 KPNA5 KRT83 L3MBTL2 L3MBTL3 LHX3 LHX4 LHX6 LMO4 MAFF MVP NDUFAB1 PANX2 PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SLC67A1-AS SP2 SP4 SPMIP10 SPSB2 SRARP TESMIN TOLLIP TRAF2 TRIM35 VEZF1 YPEL3 ZMYM6	58 interacting genes: ASB6 BANP BYSL C1QTNF4 CRLF3 DEF6 DNMT1 DRC4 FLAD1 FNDC3B FXR2 H3C1 HIF1A HSF2BP IL16 KANK2 KDM1A LIG1 LMO4 LRRK2 LSM4 LZTR1 MAPK3 MAPK9 MFAP1 MORF4L1 MORF4L2 NGB NRF1 NTAQ1 OAZ3 PDE6G PHC2 PHF21A PIK3R3 PLEKHF1 PLEKHF2 PLOD3 POLR2L PPP2CA PRKAA1 PRKAA2 RHOBTB3 SFMBT2 SNRPB SOX2 SP100 SPANXN2 SUFU SUMO1P1 TBC1D1 TCEANC THRA TRAF3IP3 TSTD2 TTC19 ZCWPW1 ZNF76
Entrez ID		4899	84456
HPRD ID		02930	11222
Ensembl ID		ENSG00000106459	ENSG00000198945
Uniprot IDs		Q16656	Q96JM7
PDB IDs		8K3D 8K4L	1WJQ 1WJS 3UT1 4FL6 4L59 7RTE 7RTI 8Y76 8Y77
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Medial Motor Column Neuron Differentiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Chromatin Zinc Ion Binding Regulation Of Primary Metabolic Process Motor Neuron Axon Guidance Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Spinal Cord Motor Neuron Cell Fate Specification Cell Differentiation In Spinal Cord RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Spinal Cord Association Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Apoptotic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Programmed Cell Death Cell Death Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm	Protein Binding Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Metabolic Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Nuclear Speck Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Glycolytic Process Positive Regulation Of Autophagy Positive Regulation Of Metabolic Process Positive Regulation Of Glycolytic Process Protein Localization To Lipid Droplet Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Carbohydrate Catabolic Process Chromatin Organization Positive Regulation Of Catabolic Process Regulation Of ATP Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Regulation Of Purine Nucleotide Metabolic Process Chromatin Binding TOR Signaling Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Negative Regulation Of TOR Signaling Macromolecule Biosynthetic Process Positive Regulation Of ATP Metabolic Process Regulation Of Programmed Cell Death Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Neuroblast Proliferation Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Phosphatidylethanolamine Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Cellular Response To Stress
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