H1-10 and RAB7A

		H1-10	RAB7A
Description		H1.10 linker histone	RAB7A, member RAS oncogene family
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GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Chromosome Nucleolus	Autophagosome Membrane Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Endosome Late Endosome Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Retromer Complex Cytoplasmic Vesicle Late Endosome Membrane Mitochondrial Membrane Melanosome Membrane Phagophore Assembly Site Membrane Phagocytic Vesicle Extracellular Exosome Alveolar Lamellar Body Bounding Membrane Of Organelle Presynaptic Endosome Glutamatergic Synapse
	Molecular Function	DNA Binding Double-stranded DNA Binding RNA Binding Structural Constituent Of Chromatin Nucleosomal DNA Binding Cadherin Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Small GTPase Binding Retromer Complex Binding
	Biological Process	Nucleosome Assembly Chromosome Condensation Negative Regulation Of DNA Recombination	Autophagosome Assembly Protein Targeting To Lysosome Lipid Metabolic Process Endocytosis Autophagy Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Response To Bacterium Protein Transport Lipid Catabolic Process Viral Release From Host Cell Protein To Membrane Docking Synaptic Vesicle Recycling Via Endosome Retrograde Transport, Endosome To Golgi Early Endosome To Late Endosome Transport Bone Resorption Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Establishment Of Vesicle Localization Protein Localization To Lysosome Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Vesicle-mediated Transport In Synapse Endosome To Plasma Membrane Protein Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation
Pathways			MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Prevention of phagosomal-lysosomal fusion Suppression of autophagy
Drugs			Guanosine-5'-Diphosphate
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)
Interacting Genes		3 interacting genes: CDC42 IL7R XBP1	24 interacting genes: CHM KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RNF167 SLC2A4 TP53 UCHL5 VPS11 VPS16 VPS18 VPS41
Entrez ID		8971	7879
HPRD ID		04151	03805
Ensembl ID		ENSG00000184897	ENSG00000075785
Uniprot IDs		Q92522	A0A158RFU6 P51149
PDB IDs		2LSO 6L9Z 7K60 7K63 8YTI	1T91 1YHN 3LAW 6IYB 6WCW 7F6J 8KB8 8ZQ3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Glutamatergic Synapse GBD Domain Binding Storage Vacuole Phagocytic Vesicle G Protein Activity Positive Regulation Of Cell Development Interleukin-7 Receptor Activity Epithelial Cell Maturation Involved In Salivary Gland Development Positive Regulation Of Lactation Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Synaptic Vesicle Recycling Via Endosome Synaptic Target Recognition Positive Regulation Of T Cell Differentiation Endothelin Receptor Signaling Pathway Involved In Heart Process Cellular Homeostasis Positive Regulation Of Lymphocyte Differentiation Response To Insulin-like Growth Factor Stimulus Regulation Of Lactation Lipophagy Medium-chain Fatty Acyl-CoA Dehydrogenase Activity Leading Edge Membrane Thioesterase Binding Positive Regulation Of Cell Population Proliferation Positive Regulation Of Pinocytosis Regulation Of Cell Migration Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Transport Positive Regulation Of Epithelial Cell Proliferation Cell Junction Assembly Neuron Fate Determination Cell Surface Receptor Signaling Pathway Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Establishment Of Organelle Localization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuropilin Signaling Pathway Golgi Transport Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Interleukin-7-mediated Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Cell Development Regulation Of Lymphocyte Differentiation Negative Regulation Of Programmed Cell Death	Vesicle-mediated Transport Intracellular Transport Endosomal Vesicle Fusion Cellular Localization Establishment Of Localization In Cell Insulin-responsive Compartment Protein Transport Endosome HOPS Complex Regulation Of SNARE Complex Assembly Establishment Of Protein Localization Intracellular Protein Transport Endosome To Lysosome Transport Vesicle Organization Lysosomal Transport Intracellular Protein Localization Cytoplasmic Vesicle CORVET Complex Clathrin-coated Vesicle Endosomal Transport Endosome Organization Late Endosome Endomembrane System Vacuolar Transport Golgi Vesicle Transport Vesicle Fusion Organelle Membrane Fusion Organelle Organization Organelle Fusion Recycling Endosome Membrane Fusion Late Endosome Membrane Endosome Membrane Cytosol Autophagy Rab-protein Geranylgeranyltransferase Complex Rab Geranylgeranyltransferase Activity Organelle Localization Meiotic Sister Chromatid Cohesion, Centromeric Membrane Organization Vesicle Tethering Complex GTPase Activity Early Endosome GTP Binding Protein Geranylgeranylation Lysosomal Membrane Presynapse Protein Prenylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Meiotic Sister Chromatid Cohesion
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