H1-10 and ACAD9

		H1-10	ACAD9
Description		H1.10 linker histone	acyl-CoA dehydrogenase family member 9
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GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Chromosome Nucleolus	Nucleus Mitochondrion Mitochondrial Inner Membrane Membrane Dendrite Mitochondrial Membrane
	Molecular Function	DNA Binding Double-stranded DNA Binding RNA Binding Structural Constituent Of Chromatin Nucleosomal DNA Binding Cadherin Binding	Acyl-CoA Dehydrogenase Activity Long-chain Fatty Acyl-CoA Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Flavin Adenine Dinucleotide Binding Medium-chain Fatty Acyl-CoA Dehydrogenase Activity
	Biological Process	Nucleosome Assembly Chromosome Condensation Negative Regulation Of DNA Recombination	Long-chain Fatty Acid Metabolic Process Fatty Acid Metabolic Process Mitochondrial Respiratory Chain Complex I Assembly Medium-chain Fatty Acid Metabolic Process
Pathways			Complex I biogenesis
Drugs
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS			Dental caries ( 23064961) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)
Interacting Genes		3 interacting genes: CDC42 IL7R XBP1
Entrez ID		8971	28976
HPRD ID		04151	12412
Ensembl ID		ENSG00000184897	ENSG00000177646
Uniprot IDs		Q92522	Q9H845 Q9H9W4
PDB IDs		2LSO 6L9Z 7K60 7K63 8YTI	8PHE 8PHF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Glutamatergic Synapse GBD Domain Binding Storage Vacuole Phagocytic Vesicle G Protein Activity Positive Regulation Of Cell Development Interleukin-7 Receptor Activity Epithelial Cell Maturation Involved In Salivary Gland Development Positive Regulation Of Lactation Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Synaptic Vesicle Recycling Via Endosome Synaptic Target Recognition Positive Regulation Of T Cell Differentiation Endothelin Receptor Signaling Pathway Involved In Heart Process Cellular Homeostasis Positive Regulation Of Lymphocyte Differentiation Response To Insulin-like Growth Factor Stimulus Regulation Of Lactation Lipophagy Medium-chain Fatty Acyl-CoA Dehydrogenase Activity Leading Edge Membrane Thioesterase Binding Positive Regulation Of Cell Population Proliferation Positive Regulation Of Pinocytosis Regulation Of Cell Migration Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Transport Positive Regulation Of Epithelial Cell Proliferation Cell Junction Assembly Neuron Fate Determination Cell Surface Receptor Signaling Pathway Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Establishment Of Organelle Localization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuropilin Signaling Pathway Golgi Transport Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Interleukin-7-mediated Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Cell Development Regulation Of Lymphocyte Differentiation Negative Regulation Of Programmed Cell Death	Endoplasmic Reticulum Organization Pronephric Nephron Development Protein-DNA Covalent Cross-linking Activity Post-spliceosomal Complex Regulation Of DNA Recombination DNA-(abasic Site) Binding Generation Of Catalytic Spliceosome For Second Transesterification Step Endosome Fission Endosome Membrane Tubulation Endoplasmic Reticulum-endosome Membrane Contact Site Signal Sequence Binding Membrane Tubulation Sec61 Translocon Complex MRNA 3'-splice Site Recognition SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation Protein-DNA Covalent Cross-linking Repair Post-mRNA Release Spliceosomal Complex Double-strand Break Repair Via Alternative Nonhomologous End Joining SRP-dependent Cotranslational Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Nephron Development Somatic Hypermutation Of Immunoglobulin Genes DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Somatic Diversification Of Immune Receptors Via Somatic Mutation Prp19 Complex U2-type Catalytic Step 1 Spliceosome Cotranslational Protein Targeting To Membrane
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