RAB7A and RPN1

Number of citations of the paper that reports this interaction (PubMedID 34079125)
0

Data Source:
BioGRID (proximity labelling technology)

		RAB7A	RPN1
Description		RAB7A, member RAS oncogene family	ribophorin I
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GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Endosome Late Endosome Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Retromer Complex Cytoplasmic Vesicle Late Endosome Membrane Mitochondrial Membrane Melanosome Membrane Phagophore Assembly Site Membrane Phagocytic Vesicle Extracellular Exosome Alveolar Lamellar Body Bounding Membrane Of Organelle Presynaptic Endosome Glutamatergic Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Cytosol Oligosaccharyltransferase Complex Membrane Melanosome Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Small GTPase Binding Retromer Complex Binding	RNA Binding Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding
	Biological Process	Autophagosome Assembly Protein Targeting To Lysosome Lipid Metabolic Process Endocytosis Autophagy Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Response To Bacterium Protein Transport Lipid Catabolic Process Viral Release From Host Cell Protein To Membrane Docking Synaptic Vesicle Recycling Via Endosome Retrograde Transport, Endosome To Golgi Early Endosome To Late Endosome Transport Bone Resorption Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Establishment Of Vesicle Localization Protein Localization To Lysosome Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Vesicle-mediated Transport In Synapse Endosome To Plasma Membrane Protein Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation	Protein Glycosylation Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine
Pathways		MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Prevention of phagosomal-lysosomal fusion Suppression of autophagy	SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs		Guanosine-5'-Diphosphate
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)	Blood protein levels ( 30072576) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Eosinophil count ( 27863252 29403010) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mild to moderate chronic kidney disease ( 31178898) Monocyte count ( 23314186 32888494 29403010 27863252) Monocyte percentage of white cells ( 27863252 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Neutrophil count ( 32888494) Platelet distribution width ( 32888494) Serum metabolite levels ( 33031748) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 21738480 32888494) White blood cell count (basophil) ( 29403010)
Interacting Genes		24 interacting genes: CHM KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RNF167 SLC2A4 TP53 UCHL5 VPS11 VPS16 VPS18 VPS41	18 interacting genes: ADRM1 DPF1 DUX4 ERBB3 HSPA5 KRTAP1-3 PSMC2 RAD23A RBBP4 RBFOX2 SGTA SIGIRR SMARCB1 UBC UBQLN1 UBQLN2 UBQLN4 WSB2
Entrez ID		7879	6184
HPRD ID		03805	01598
Ensembl ID		ENSG00000075785	ENSG00000163902
Uniprot IDs		A0A158RFU6 P51149	P04843
PDB IDs		1T91 1YHN 3LAW 6IYB 6WCW 7F6J 8KB8 8ZQ3	6S7O 6S7T 8B6L 8PN9
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Intracellular Transport Endosomal Vesicle Fusion Cellular Localization Establishment Of Localization In Cell Insulin-responsive Compartment Protein Transport Endosome HOPS Complex Regulation Of SNARE Complex Assembly Establishment Of Protein Localization Intracellular Protein Transport Endosome To Lysosome Transport Vesicle Organization Lysosomal Transport Intracellular Protein Localization Cytoplasmic Vesicle CORVET Complex Clathrin-coated Vesicle Endosomal Transport Endosome Organization Late Endosome Endomembrane System Vacuolar Transport Golgi Vesicle Transport Vesicle Fusion Organelle Membrane Fusion Organelle Organization Organelle Fusion Recycling Endosome Membrane Fusion Late Endosome Membrane Endosome Membrane Cytosol Autophagy Rab-protein Geranylgeranyltransferase Complex Rab Geranylgeranyltransferase Activity Organelle Localization Meiotic Sister Chromatid Cohesion, Centromeric Membrane Organization Vesicle Tethering Complex GTPase Activity Early Endosome GTP Binding Protein Geranylgeranylation Lysosomal Membrane Presynapse Protein Prenylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Meiotic Sister Chromatid Cohesion	Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome Complex Regulation Of Cellular Response To Stress Positive Regulation Of ERAD Pathway Proteolysis Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of ERAD Pathway Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of G0 To G1 Transition Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Protein Metabolic Process Autophagosome Regulation Of Metabolic Process Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Protein-containing Complex NBAF Complex Autophagosome Assembly Proteasome Binding Cytosol Autophagosome Organization Nucleoplasm Autophagy Regulation Of Primary Metabolic Process Regulation Of Nucleotide-excision Repair Regulation Of Double-strand Break Repair Nucleosomal DNA Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Vacuole Organization Negative Regulation Of Transport
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