H1FX and IL7R

Number of citations of the paper that reports this interaction (PMID 23151878)
3

Data Source:
BioGRID (unspecified method)

		H1FX	IL7R
Gene Name		H1 histone family, member X	interleukin 7 receptor
Image
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Nucleolus	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	DNA Binding Poly(A) RNA Binding	Antigen Binding Interleukin-7 Receptor Activity Protein Binding
	Biological Process	Nucleosome Assembly	Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Size Positive Regulation Of Gene Expression Cell Growth T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells
Pathways			Signaling by Interleukins Interleukin-7 signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Multiple sclerosis ( 21244703 19525953 21833088) Primary biliary cirrhosis ( 23000144 21399635) Type 1 diabetes ( 17554260) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		2 interactors: IL7R XBP1	104 interactors: ALYREF CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 GNB2L1 H1FX HIST1H1C HIST1H1E HIST2H2BE HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MAP4 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787
Entrez ID		8971	3575
HPRD ID		04151	00893
Ensembl ID		ENSG00000184897	ENSG00000168685
Uniprot IDs		Q92522	D6RGV2 D9N160 P16871
PDB IDs		2LSO	3DI2 3DI3 3UP1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Regulation Of T Cell Differentiation Cell Growth Regulation Of Lymphocyte Differentiation Positive Regulation Of T Cell Activation Positive Regulation Of Lactation Positive Regulation Of Plasma Cell Differentiation Serotonin Secretion, Neurotransmission Epithelial Cell Maturation Involved In Salivary Gland Development Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Interleukin-7-mediated Signaling Pathway Cell Differentiation Involved In Salivary Gland Development Positive Regulation Of Cell Activation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of T Cell Mediated Cytotoxicity Serotonin Secretion Regulation Of Cell Activation Growth Positive Regulation Of Hepatocyte Proliferation Cellular Response To Fructose Stimulus Positive Regulation Of Interleukin-6 Secretion Cellular Response To Laminar Fluid Shear Stress Serotonin Transport Positive Regulation Of MHC Class II Biosynthetic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Immunoglobulin Secretion Regulation Of Cell Adhesion Exocrine Pancreas Development Cellular Triglyceride Homeostasis Response To Fructose Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Hepatocyte Proliferation Response To Cytokine Cell Proliferation Negative Regulation Of Myotube Differentiation Negative Regulation Of T Cell Mediated Immunity Fatty Acid Homeostasis Regulation Of Immunoglobulin Secretion Lymph Node Development Positive Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Cell Differentiation	MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing RNA Splicing MRNA Processing RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Viral Process RNA Biosynthetic Process SRP-dependent Cotranslational Protein Targeting To Membrane Termination Of RNA Polymerase II Transcription Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein Localization To Endoplasmic Reticulum Viral Life Cycle Cytoplasmic Transport Posttranscriptional Regulation Of Gene Expression MRNA Stabilization RNA 3'-end Processing MRNA 3'-end Processing RNA Catabolic Process Viral Transcription Cellular Metabolic Process Protein Targeting To Membrane DNA-templated Transcription, Termination Protein Targeting Nuclear-transcribed MRNA Catabolic Process Establishment Of Protein Localization To Organelle MRNA Catabolic Process Ribonucleoprotein Complex Assembly Regulation Of Translation Ribonucleoprotein Complex Biogenesis Biosynthetic Process Protein Localization To Organelle Translational Termination Establishment Of Protein Localization To Membrane Intracellular Transport Translational Elongation
Tagcloud ?		a6 anuran arg chromatinized covalent egg eggs erythrocytes h1b h2a h4 heparin histones immunoblotted isolating laevis lys metazoan methylated neurula oocyte predeposition proceeds pronuclei s3 sepharose sperm stored xenopus	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		a6 anuran arg chromatinized covalent egg eggs erythrocytes h1b h2a h4 heparin histones immunoblotted isolating laevis lys metazoan methylated neurula oocyte predeposition proceeds pronuclei s3 sepharose sperm stored xenopus	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?