RAB7A and FABP6

Data Source: HiPPIP (Novel)

		RAB7A	FABP6
Name		RAB7A, member RAS oncogene family	fatty acid binding protein 6
Structure
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Endosome Late Endosome Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Retromer Complex Cytoplasmic Vesicle Late Endosome Membrane Mitochondrial Membrane Melanosome Membrane Phagophore Assembly Site Membrane Phagocytic Vesicle Extracellular Exosome Alveolar Lamellar Body Bounding Membrane Of Organelle Presynaptic Endosome Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Small GTPase Binding Retromer Complex Binding	Fatty Acid Binding Lipid Binding
	Biological Process	Autophagosome Assembly Protein Targeting To Lysosome Lipid Metabolic Process Endocytosis Autophagy Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Response To Bacterium Protein Transport Lipid Catabolic Process Viral Release From Host Cell Protein To Membrane Docking Synaptic Vesicle Recycling Via Endosome Retrograde Transport, Endosome To Golgi Early Endosome To Late Endosome Transport Bone Resorption Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Establishment Of Vesicle Localization Protein Localization To Lysosome Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Vesicle-mediated Transport In Synapse Endosome To Plasma Membrane Protein Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation	Lipid Metabolic Process Lipid Transport Negative Regulation Of Cell Population Proliferation Fatty Acid Transport
Pathways		MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Prevention of phagosomal-lysosomal fusion Suppression of autophagy	Recycling of bile acids and salts Triglyceride catabolism NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs		Guanosine-5'-Diphosphate	Cholic Acid Glycocholic acid Taurocholic acid
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	None
GWAS		Body fat mass ( 28552196 ) Facial morphology traits (63 three-dimensional facial segments) ( 29459680 )	Cardiometabolic and hematological traits ( 27668658 ) Heel bone mineral density ( 30598549 ) Mean platelet volume ( 32888494 ) Platelet count ( 29403010 32888494 ) Platelet distribution width ( 32888494 )
Novel Interactors		8 novel interactors: COPG1 ENOPH1 FABP6 GP9 H1-10 RPN1 TMCC1 ZHX2	1 novel interactors: RAB7A
Interacting Genes		24 interacting genes: CHM KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RNF167 SLC2A4 TP53 UCHL5 VPS11 VPS16 VPS18 VPS41	None recorded
Entrez ID		7879	2172
HPRD ID		03805	02689
Ensembl ID		ENSG00000075785	ENSG00000170231
Uniprot IDs		A0A158RFU6 P51149	P51161
PDB IDs		1T91 1YHN 3LAW 6IYB 6WCW 7F6J 8KB8 8ZQ3	1O1U 1O1V 2MM3 5L8I 5L8N 5L8O
GO Terms Enriched among Interactors		Vesicle-mediated Transport Intracellular Transport Endosomal Vesicle Fusion Cellular Localization Establishment Of Localization In Cell Insulin-responsive Compartment Protein Transport Endosome HOPS Complex Regulation Of SNARE Complex Assembly Establishment Of Protein Localization Intracellular Protein Transport Endosome To Lysosome Transport Vesicle Organization Lysosomal Transport Intracellular Protein Localization Cytoplasmic Vesicle CORVET Complex Clathrin-coated Vesicle Endosomal Transport Endosome Organization Late Endosome Endomembrane System Vacuolar Transport Golgi Vesicle Transport Vesicle Fusion Organelle Membrane Fusion Organelle Organization Organelle Fusion Recycling Endosome Membrane Fusion Late Endosome Membrane Endosome Membrane Cytosol Autophagy Rab-protein Geranylgeranyltransferase Complex Rab Geranylgeranyltransferase Activity Organelle Localization Meiotic Sister Chromatid Cohesion, Centromeric Membrane Organization Vesicle Tethering Complex GTPase Activity Early Endosome GTP Binding Protein Geranylgeranylation Lysosomal Membrane Presynapse Protein Prenylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Meiotic Sister Chromatid Cohesion	Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Synaptic Vesicle Recycling Via Endosome Lipophagy Negative Regulation Of Exosomal Secretion Protein To Membrane Docking Regulation Of Endosome Organization Alveolar Lamellar Body Phagosome Acidification Presynaptic Endosome Retromer Complex Binding Phagosome Maturation Neurotransmitter Receptor Transport Phagosome-lysosome Fusion Endosome To Plasma Membrane Protein Transport Synaptic Vesicle Recycling Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Bounding Membrane Of Organelle Melanosome Membrane Phagophore Assembly Site Membrane Retromer Complex Early Endosome To Late Endosome Transport Bone Resorption Viral Release From Host Cell Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Targeting To Lysosome Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Exocytosis Autophagosome Membrane Intracellular PH Reduction Endosome To Lysosome Transport Protein Targeting To Vacuole Establishment Of Protein Localization To Plasma Membrane Protein Localization To Lysosome Establishment Of Protein Localization To Vacuole Positive Regulation Of Viral Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein-containing Complex Localization G Protein Activity GDP Binding Endocytic Recycling Regulation Of ERBB Signaling Pathway Regulation Of Cellular PH Protein Localization To Vacuole Membrane Docking Lipid Droplet Retrograde Transport, Endosome To Golgi Positive Regulation Of Exocytosis