ZFPM1 and CTBP2

Number of citations of the paper that reports this interaction (PMID 9724649)
95

Data Source:
HPRD (two hybrid, in vitro)

		ZFPM1	CTBP2
Gene Name		zinc finger protein, FOG family member 1	C-terminal binding protein 2
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Transcriptional Repressor Complex	Nucleus Transcriptional Repressor Complex Cell Junction Synapse
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding DNA Binding Protein Binding Transcription Factor Binding Metal Ion Binding	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Retinoic Acid Receptor Binding NAD Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter T-helper Cell Lineage Commitment Outflow Tract Morphogenesis Atrioventricular Valve Morphogenesis Mitral Valve Formation Tricuspid Valve Formation Transcription, DNA-templated Heart Development Blood Coagulation Regulation Of Definitive Erythrocyte Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Granulocyte Differentiation Negative Regulation Of Protein Binding Regulation Of Chemokine Production Embryonic Hemopoiesis Megakaryocyte Development Positive Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of Interleukin-4 Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Cardiac Muscle Tissue Morphogenesis Definitive Erythrocyte Differentiation Primitive Erythrocyte Differentiation Negative Regulation Of Mast Cell Differentiation Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Transcriptional Activation By Promoter-enhancer Looping	Transcription, DNA-templated Negative Regulation Of Cell Proliferation Viral Genome Replication Positive Regulation Of Chromatin Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Retinoic Acid Receptor Signaling Pathway White Fat Cell Differentiation Oxidation-reduction Process
Pathways		Factors involved in megakaryocyte development and platelet production	APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated repression of WNT target genes S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer truncations of AMER1 destabilize the destruction complex
Drugs
Diseases
GWAS			Prostate cancer ( 18264096)
Protein-Protein Interactions		6 interactors: CTBP2 GATA1 GATA2 GIPC1 GSK3B TOP3B	67 interactors: ACTG1 AKTIP APP BAZ2B BCAS3 BCL3 C15orf39 CASP8AP2 CBX4 CCNH CCR5 CDKN2A CTBP1 CTPS2 DMRTB1 DVL2 EEF1D ELAC2 EP300 FHL3 FLI1 FOXP2 FUNDC1 HIC1 HIST3H3 HOXB5 IKZF1 IKZF2 KLF3 KLF8 LCOR MDM2 MECOM NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 RAI2 RBBP8 RIMBP3 RPL17 RPL7A RPS28 RPS29 RPS4X RUNX1 SOX13 SOX6 STUB1 STX11 TEAD3 TGIF1 TSHZ3 UBE2I XRCC6 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750
Entrez ID		161882	1488
HPRD ID		11800	04016
Ensembl ID			ENSG00000175029
Uniprot IDs		Q8IX07	P56545 Q5SQP8
PDB IDs		2XU7	2OME
Enriched GO Terms of Interacting Partners?		Eosinophil Fate Commitment Eosinophil Differentiation Granulocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Regulation Of Binding Negative Regulation Of Cellular Metabolic Process Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Myeloid Cell Differentiation Regulation Of Cellular Ketone Metabolic Process Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Binding Positive Regulation Of Cellular Biosynthetic Process Myeloid Leukocyte Differentiation Positive Regulation Of Binding Fat Cell Differentiation Negative Regulation Of Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Basophil Differentiation Superior Temporal Gyrus Development Regulation Of Cellular Protein Metabolic Process Regulation Of Synaptic Plasticity Re-entry Into Mitotic Cell Cycle Negative Regulation Of Fat Cell Proliferation Transcriptional Activation By Promoter-enhancer Looping Negative Regulation Of Neuron Maturation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Cell Differentiation Regulation Of Protein Metabolic Process Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Definitive Erythrocyte Differentiation Cellular Response To Interleukin-3 Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromatin Binding Regulation Of Forebrain Neuron Differentiation Homeostasis Of Number Of Cells Myeloid Cell Differentiation Stem Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity	RNA Biosynthetic Process Gene Expression RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Viral Process Metabolic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryo Development Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Developmental Process Cellular Process Multicellular Organismal Development Muscle Structure Development Muscle Organ Development Organ Development Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		anaemia artiodactyls c57bl cattle congolense constraints contributor cyclosporin erythropoiesis erythropoietin gata1 haematopoiesis haematopoietic haemolysis ifng il6 insensitive klf1 observable parasitaemia parasites persists protozoan recover resolves stream surviving trypanosoma undetectable	acetylates acetylation corepressor correlating ctbps deacetylases demethylase dimerization ex527 exerts hdac hypoxic influencing interacted kdm1 ligation lsd1 microenvironmental modifying nscs pla proliferating proximity sensors sirt1 transferase unaltered undifferentiated
Tagcloud (Difference) ?		anaemia artiodactyls c57bl cattle congolense constraints contributor cyclosporin erythropoiesis erythropoietin gata1 haematopoiesis haematopoietic haemolysis ifng il6 insensitive klf1 observable parasitaemia parasites persists protozoan recover resolves stream surviving trypanosoma undetectable	acetylates acetylation corepressor correlating ctbps deacetylases demethylase dimerization ex527 exerts hdac hypoxic influencing interacted kdm1 ligation lsd1 microenvironmental modifying nscs pla proliferating proximity sensors sirt1 transferase unaltered undifferentiated
Tagcloud (Intersection) ?