ZFPM1 and TOP3B

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		ZFPM1	TOP3B
Description		zinc finger protein, FOG family member 1	DNA topoisomerase III beta
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex	Condensed Chromosome Nucleus DNA Topoisomerase III-beta-TDRD3 Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding Isomerase Activity RNA Topoisomerase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production T-helper Cell Lineage Commitment Immune System Process Leukocyte Differentiation Outflow Tract Morphogenesis Atrioventricular Valve Morphogenesis Mitral Valve Formation Tricuspid Valve Formation Regulation Of Transcription By RNA Polymerase II Heart Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Definitive Erythrocyte Differentiation Myeloid Cell Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Granulocyte Differentiation Regulation Of Chemokine Production Negative Regulation Of Interleukin-4 Production Positive Regulation Of Type II Interferon Production Embryonic Hemopoiesis Megakaryocyte Development Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Homeostasis Of Number Of Cells Negative Regulation Of Multicellular Organismal Process Cardiac Muscle Tissue Morphogenesis Definitive Erythrocyte Differentiation Primitive Erythrocyte Differentiation Negative Regulation Of Mast Cell Differentiation Ventricular Septum Morphogenesis Atrial Septum Morphogenesis	DNA Topological Change DNA Repair DNA Recombination Chromosome Segregation
Pathways		RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Bone mineral accretion in asthma (oral corticosteroid dose interaction) ( 26025128) Calcium levels ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Hair color ( 26926045) Hematocrit ( 27863252 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731 33339817 29083408) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Platelet count ( 27863252 32888494 29403010) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) PR interval ( 32439900) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Serum alkaline phosphatase levels ( 33547301) Sum eosinophil basophil counts ( 27863252) Testicular germ cell tumor ( 26503584 28604728 28604732) Total cholesterol levels ( 33339817) Vascular endothelial growth factor levels ( 26910538) White blood cell count (basophil) ( 27863252 29403010)	Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)
Interacting Genes		6 interacting genes: CTBP2 GATA1 GATA2 GIPC1 GSK3B TOP3B	25 interacting genes: ADAMTSL4 AXIN2 C1QBP CENPF CHD8 CHIC2 CIAO1 FASTK FBLN5 GPRASP3 GRN KANK2 KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TDRD3 TRIM41 UPF2 ZFPM1 ZNF250 ZNF408
Entrez ID		161882	8940
HPRD ID		11800	04662
Ensembl ID		ENSG00000179588	ENSG00000100038
Uniprot IDs		Q8IX07	A8K4N2 O95985
PDB IDs		2XU7	5GVC 5GVE 9C9W 9C9Y 9CA0 9CA1 9CA4 9CAG 9CAH 9CAJ 9CAK 9CAL
Enriched GO Terms of Interacting Partners?		Eosinophil Fate Commitment Regulation Of Primitive Erythrocyte Differentiation Transcription Coregulator Binding C2H2 Zinc Finger Domain Binding Positive Regulation Of Mast Cell Degranulation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Mast Cell Degranulation Positive Regulation Of Erythrocyte Differentiation Homeostasis Of Number Of Cells Within A Tissue Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Regulated Secretory Pathway Transcription Coactivator Binding Regulation Of Erythrocyte Differentiation Transcription Repressor Complex Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process P53 Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Exocytosis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome RNA Topoisomerase Activity Positive Regulation Of Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Basophil Differentiation Positive Regulation Of Myeloid Cell Differentiation Semicircular Canal Development Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity DNA Topoisomerase III-beta-TDRD3 Complex Negative Regulation Of Protein Catabolic Process Regulation Of Regulated Secretory Pathway Fat Cell Differentiation Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Viral Process Regulation Of Definitive Erythrocyte Differentiation Ventral Spinal Cord Interneuron Differentiation Negative Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Cell Population Proliferation Regulation Of Extrinsic Apoptotic Signaling Pathway Primitive Erythrocyte Differentiation
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