ZFPM1 and GATA2

Number of citations of the paper that reports this interaction (PMID 12483298)
7

Data Source:
HPRD (in vivo)

		ZFPM1	GATA2
Gene Name		zinc finger protein, FOG family member 1	GATA binding protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Transcriptional Repressor Complex	Nucleoplasm Protein Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding DNA Binding Protein Binding Transcription Factor Binding Metal Ion Binding	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Enhancer Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter T-helper Cell Lineage Commitment Outflow Tract Morphogenesis Atrioventricular Valve Morphogenesis Mitral Valve Formation Tricuspid Valve Formation Transcription, DNA-templated Heart Development Blood Coagulation Regulation Of Definitive Erythrocyte Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Granulocyte Differentiation Negative Regulation Of Protein Binding Regulation Of Chemokine Production Embryonic Hemopoiesis Megakaryocyte Development Positive Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of Interleukin-4 Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Cardiac Muscle Tissue Morphogenesis Definitive Erythrocyte Differentiation Primitive Erythrocyte Differentiation Negative Regulation Of Mast Cell Differentiation Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Transcriptional Activation By Promoter-enhancer Looping	Negative Regulation Of Transcription From RNA Polymerase II Promoter Urogenital System Development Cell Fate Determination Embryonic Placenta Development Transcription, DNA-templated Phagocytosis Blood Coagulation Ventral Spinal Cord Interneuron Differentiation Cell Differentiation In Hindbrain Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Development Pituitary Gland Development Somatic Stem Cell Maintenance Regulation Of Histone Acetylation Eosinophil Fate Commitment Inner Ear Morphogenesis Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Phagocytosis Definitive Hemopoiesis Semicircular Canal Development Negative Regulation Of Fat Cell Proliferation GABAergic Neuron Differentiation Negative Regulation Of Neural Precursor Cell Proliferation Regulation Of Forebrain Neuron Differentiation
Pathways		Factors involved in megakaryocyte development and platelet production	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Eosinophil counts ( 19198610) White blood cell count ( 21738480) White blood cell types ( 21738478)
Protein-Protein Interactions		6 interactors: CTBP2 GATA1 GATA2 GIPC1 GSK3B TOP3B	34 interactors: ADAMTSL4 AKT1 CEBPA EP300 FHL3 GOLGA2 HDAC3 HDAC5 HHEX JUN KAT2A KRT40 KRTAP10-3 KRTAP10-9 LMO2 MAPK1 MDFI NOTCH2NL PML POU1F1 POU2AF1 PRR20A PSMA3 RARA RXRA SMAD4 SPI1 STAT3 TAL1 TRAF1 TRIM23 ZBTB16 ZBTB32 ZFPM1
Entrez ID		161882	2624
HPRD ID		11800	00673
Ensembl ID			ENSG00000179348
Uniprot IDs		Q8IX07	P23769
PDB IDs		2XU7
Enriched GO Terms of Interacting Partners?		Eosinophil Fate Commitment Eosinophil Differentiation Granulocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Regulation Of Binding Negative Regulation Of Cellular Metabolic Process Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Myeloid Cell Differentiation Regulation Of Cellular Ketone Metabolic Process Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Binding Positive Regulation Of Cellular Biosynthetic Process Myeloid Leukocyte Differentiation Positive Regulation Of Binding Fat Cell Differentiation Negative Regulation Of Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Basophil Differentiation Superior Temporal Gyrus Development Regulation Of Cellular Protein Metabolic Process Regulation Of Synaptic Plasticity Re-entry Into Mitotic Cell Cycle Negative Regulation Of Fat Cell Proliferation Transcriptional Activation By Promoter-enhancer Looping Negative Regulation Of Neuron Maturation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Cell Differentiation Regulation Of Protein Metabolic Process Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Definitive Erythrocyte Differentiation Cellular Response To Interleukin-3 Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromatin Binding Regulation Of Forebrain Neuron Differentiation Homeostasis Of Number Of Cells Myeloid Cell Differentiation Stem Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Organ Development Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Hemopoiesis Immune System Development Embryo Development System Development Multicellular Organismal Development Biosynthetic Process Immune System Process Cellular Nitrogen Compound Metabolic Process Cardiovascular System Development Gland Development Regulation Of Metabolic Process Myeloid Cell Differentiation Regulation Of Binding Developmental Process Anatomical Structure Development Nitrogen Compound Metabolic Process Regulation Of Cell Differentiation Protein Localization To Nucleus Regulation Of Myeloid Cell Differentiation Nucleobase-containing Compound Metabolic Process Tissue Development
Tagcloud ?		anaemia artiodactyls c57bl cattle congolense constraints contributor cyclosporin erythropoiesis erythropoietin gata1 haematopoiesis haematopoietic haemolysis ifng il6 insensitive klf1 observable parasitaemia parasites persists protozoan recover resolves stream surviving trypanosoma undetectable	arises begins betah1 commitment conceptus conceptuses e7 e8 ectodermal erythroblasts erythropoiesis extraembryonic gastrulation globin headfold islands mesoderm morphologically ordered primitive proceeds rbtn2 recognizable sac somite streak vys yolk
Tagcloud (Difference) ?		anaemia artiodactyls c57bl cattle congolense constraints contributor cyclosporin erythropoietin gata1 haematopoiesis haematopoietic haemolysis ifng il6 insensitive klf1 observable parasitaemia parasites persists protozoan recover resolves stream surviving trypanosoma undetectable	arises begins betah1 commitment conceptus conceptuses e7 e8 ectodermal erythroblasts extraembryonic gastrulation globin headfold islands mesoderm morphologically ordered primitive proceeds rbtn2 recognizable sac somite streak vys yolk
Tagcloud (Intersection) ?		erythropoiesis