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WASF1 and ABL1
Number of citations of the paper that reports this interaction (PMID
10970852
)
61
Data Source:
HPRD
(in vivo, in vitro)
WASF1
ABL1
Gene Name
WAS protein family, member 1
ABL proto-oncogene 1, non-receptor tyrosine kinase
Image
Gene Ontology Annotations
Cellular Component
Cytoskeleton
Actin Cytoskeleton
Cell Junction
SCAR Complex
Synapse
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Actin Cytoskeleton
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cell Leading Edge
Nuclear Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
Actin Binding
Protein Binding
Protein Complex Binding
Rac GTPase Binding
Magnesium Ion Binding
DNA Binding
Actin Monomer Binding
Nicotinate-nucleotide Adenylyltransferase Activity
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Receptor Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
SH3 Domain Binding
Syntaxin Binding
Manganese Ion Binding
Actin Filament Binding
Mitogen-activated Protein Kinase Binding
Proline-rich Region Binding
Biological Process
Protein Complex Assembly
Movement Of Cell Or Subcellular Component
Rac Protein Signal Transduction
Actin Filament Polymerization
Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
B-1 B Cell Homeostasis
B Cell Proliferation Involved In Immune Response
Transitional One Stage B Cell Differentiation
Mismatch Repair
Regulation Of Transcription, DNA-templated
Cellular Protein Modification Process
Autophagy
Cellular Response To DNA Damage Stimulus
DNA Damage Induced Protein Phosphorylation
Response To Oxidative Stress
Cell Cycle Arrest
Mitotic Nuclear Division
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Axon Guidance
Blood Coagulation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Autophagy
Cell Migration
Peptidyl-tyrosine Phosphorylation
Cerebellum Morphogenesis
Negative Regulation Of Cell-cell Adhesion
Microspike Assembly
Actin Cytoskeleton Organization
Regulation Of Endocytosis
Cell Differentiation
Regulation Of Cell Adhesion
Negative Regulation Of BMP Signaling Pathway
Positive Regulation Of Osteoblast Proliferation
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Oxidative Stress
Peptidyl-tyrosine Autophosphorylation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Cell Proliferation
Muscle Cell Differentiation
Signal Transduction In Response To DNA Damage
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Alpha-beta T Cell Differentiation
Platelet-derived Growth Factor Receptor Signaling Pathway
Spleen Development
Thymus Development
Collateral Sprouting
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Activated T Cell Proliferation
B Cell Receptor Signaling Pathway
Neuromuscular Process Controlling Balance
Positive Regulation Of Muscle Cell Differentiation
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Oxidoreductase Activity
Negative Regulation Of Ubiquitin-protein Transferase Activity
Mitochondrial Depolarization
Bergmann Glial Cell Differentiation
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Negative Regulation Of Protein Serine/threonine Kinase Activity
Actin Filament Branching
Positive Regulation Of Interleukin-2 Secretion
Negative Regulation Of Phospholipase C Activity
Positive Regulation Of Neuron Death
Positive Regulation Of Interferon-gamma Secretion
Regulation Of Extracellular Matrix Organization
Cellular Response To Dopamine
Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Cell Motility
Regulation Of Actin Cytoskeleton Reorganization
Negative Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Cellular Senescence
Regulation Of Response To DNA Damage Stimulus
Pathways
Signaling by VEGF
Fcgamma receptor (FCGR) dependent phagocytosis
VEGFA-VEGFR2 Pathway
Regulation of actin dynamics for phagocytic cup formation
Innate Immune System
Role of Abl in Robo-Slit signaling
CDO in myogenesis
Axon guidance
Myogenesis
Fcgamma receptor (FCGR) dependent phagocytosis
Factors involved in megakaryocyte development and platelet production
Signaling by Robo receptor
Regulation of actin dynamics for phagocytic cup formation
Innate Immune System
Drugs
Adenosine triphosphate
Imatinib
Dasatinib
N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
Nilotinib
Bosutinib
2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
MYRISTIC ACID
6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
Regorafenib
Ponatinib
Diseases
GWAS
Response to amphetamines (
22952603
)
Protein-Protein Interactions
28 interactors:
ABI1
ABL1
ACTB
ACTG1
ACTR2
BAD
BAIAP2
BRK1
CDC42
CDK5
CRK
CXCL8
CYFIP2
DNMBP
FYN
GNAI1
GRB2
IFT20
IL12A
NCK1
NCKAP1
PFN1
PRKAR2A
PSTPIP1
RAC1
SORBS2
SRGAP3
TRIP10
145 interactors:
ABI1
ABI2
ABL2
ACTA1
ADAM15
ANKRA2
APBB1
APP
ARHGAP17
ATM
ATR
BCAR1
BCR
BIN1
BRCA1
BTK
C3
CABLES1
CABLES2
CASP9
CAT
CAV1
CBL
CCND2
CD19
CDK1
CDK5
CDKN1B
CDON
CREB1
CRK
CRKL
CTNND2
DDB1
DDB2
DOK1
DOK2
DOK3
EGFR
ENAH
EP300
EPHA3
EPHB2
ERBB2
ERBB3
ERBB4
EVL
GPX1
GRB10
GRB2
GRIN2D
GTF2F1
HCK
HUWE1
INPPL1
JAK1
JAK2
JUN
KIT
LATS2
MAP4K1
MAP4K5
MAPT
MAVS
MBP
MDM2
MICAL1
MUC1
NCK1
NCOA3
NCSTN
NEDD4
NEDD4L
NEDD9
NFKBIA
NTRK1
PAG1
PAK2
PDE4D
PIK3R1
PLCG1
PLSCR1
POLR2A
PRDX1
PRKD1
PRKDC
PSMA7
PSTPIP1
PTPN12
PTPN18
PTPN6
PXN
RAD51
RAD52
RAD9A
RAN
RAPGEF1
RASA1
RB1
RFX1
RIN1
ROBO1
ROS1
RYBP
SFN
SH3BP1
SH3BP2
SHD
SHE
SLC9A2
SORBS1
SORBS2
SORBS3
SOS2
SPRR2A
SPTA1
SPTAN1
SRC
SRPK2
ST5
STUB1
TERT
TOPBP1
TP53
TP73
TRAF6
TUB
UBC
VAV1
WASF1
WASF2
WASL
WRNIP1
XPO1
XRCC6
YAP1
YTHDC1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZAP70
ZDHHC16
Entrez ID
8936
25
HPRD ID
05434
01809
Ensembl ID
ENSG00000112290
ENSG00000097007
Uniprot IDs
Q92558
P00519
Q59FK4
PDB IDs
3P8C
1AB2
1ABL
1AWO
1BBZ
1JU5
1OPL
1ZZP
2ABL
2E2B
2F4J
2FO0
2G1T
2G2F
2G2H
2G2I
2GQG
2HIW
2HYY
2HZ0
2HZ4
2HZI
2O88
2V7A
3CS9
3EG0
3EG1
3EG2
3EG3
3EGU
3K2M
3PYY
3QRI
3QRJ
3QRK
3T04
3UE4
3UYO
Enriched GO Terms of Interacting Partners
?
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc-gamma Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc Receptor Signaling Pathway
Endocytosis
Phagocytosis
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Vesicle-mediated Transport
Innate Immune Response
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Immune Response
Defense Response
Positive Regulation Of Immune System Process
Positive Regulation Of Immune Response
Regulation Of Immune Response
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Immune System Process
Actin Cytoskeleton Organization
Actin Filament-based Process
Immune System Process
Response To Stress
Signaling
Blood Coagulation
Cell Communication
Hemostasis
Movement Of Cell Or Subcellular Component
Signal Transduction
Regulation Of Actin Cytoskeleton Organization
Regulation Of Cytoskeleton Organization
Cell Surface Receptor Signaling Pathway
Regulation Of Organelle Organization
Regulation Of Actin Filament-based Process
Transport
Cellular Response To Stimulus
Regulation Of Body Fluid Levels
Locomotion
Wound Healing
Cell Projection Morphogenesis
Cell Part Morphogenesis
Cytoskeleton Organization
Cell Projection Organization
Response To Stimulus
Response To Wounding
Axonogenesis
Axon Guidance
Ephrin Receptor Signaling Pathway
Axon Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Stimulus
Response To Stimulus
Signal Transduction
Regulation Of Signaling
Regulation Of Signal Transduction
Signaling
Cell Communication
Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Response To Stress
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Programmed Cell Death
Innate Immune Response
Cell Death
Death
Immune System Process
Apoptotic Process
Immune Response-regulating Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Response To Organic Substance
Regulation Of Cell Death
Neurotrophin Signaling Pathway
Regulation Of Apoptotic Process
Positive Regulation Of Metabolic Process
Fc Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Cellular Response To Growth Factor Stimulus
Regulation Of Phosphorylation
Immune Response
Cell Differentiation
Response To Growth Factor
Regulation Of Immune Response
Cellular Response To Organic Substance
Regulation Of Catalytic Activity
Regulation Of Phosphorus Metabolic Process
Defense Response
Regulation Of Cellular Component Organization
Cell Development
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Cellular Process
ERBB Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cellular Metabolic Process
Regulation Of Intracellular Signal Transduction
Locomotion
Anatomical Structure Development
Movement Of Cell Or Subcellular Component
Tagcloud
?
aba
abi1
abscisic
advantage
arabidopsis
assayed
character
contrary
copies
defense
dormancy
drought
implicates
lap
le25
meja
mrnas
pin2
proteinase
requisite
seed
signalling
tas14
tomato
transcripts
transformants
wilty
wound
wounding
Tagcloud (Difference)
?
aba
abi1
abscisic
advantage
arabidopsis
assayed
character
contrary
copies
defense
dormancy
drought
implicates
lap
le25
meja
mrnas
pin2
proteinase
requisite
seed
signalling
tas14
tomato
transcripts
transformants
wilty
wound
wounding
Tagcloud (Intersection)
?