WASF1

Name	WASP family member 1
Structure
Novel Interactors	1 novel interactors: MMS22L
Interactors	38 interactors: ABI1 ABI3 ABL1 ACTB ACTG1 ACTR2 BAD BRK1 CCDC196 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP EFHC1 FYN GNAI1 GRB2 HSF2BP IFT20 IL12A ING5 LMO2 MAPKAPK2 NCK1 NCK2 NCKAP1 NYAP2 OSTF1 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRAF2 TRIP10
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton Focal Adhesion Actin Cytoskeleton Lamellipodium SCAR Complex Dendrite Cytoplasm Protein-containing Complex Synapse Anchoring Junction Postsynapse
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Arp2/3 Complex Binding
	Biological Process	Receptor-mediated Endocytosis Mitochondrion Organization Rac Protein Signal Transduction Actin Cytoskeleton Organization Actin Filament Polymerization Neuron Projection Development Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein-containing Complex Assembly Lamellipodium Morphogenesis Dendrite Extension Modification Of Postsynaptic Actin Cytoskeleton Dendritic Transport Of Mitochondrion Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
GWAS	No GWAS studies recorded
Entrez ID	8936
HPRD ID	05434
Ensembl ID	ENSG00000112290
Uniprot IDs	Q92558
PDB IDs	3P8C 4N78 7USC 7USD 7USE
GO Terms Enriched among Interactors ?	Actin Cytoskeleton Organization Actin Filament-based Process Cell Motility Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization SCAR Complex Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Cytoskeleton Organization Lamellipodium Cell Migration Cell Projection Morphogenesis Regulation Of Supramolecular Fiber Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Actin Filament Polymerization Regulation Of Cell Projection Organization Regulation Of Lamellipodium Organization Regulation Of Protein-containing Complex Assembly Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Lamellipodium Assembly Ephrin Receptor Binding Positive Regulation Of Cell Projection Organization Cell Projection Assembly Neuron Projection Morphogenesis Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Adhesion Positive Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Adhesion Positive Regulation Of Lamellipodium Organization Signaling Adaptor Activity Positive Regulation Of Protein Polymerization Regulation Of Cell Projection Assembly Lamellipodium Organization Establishment Or Maintenance Of Cell Polarity Phosphotyrosine Residue Binding Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cellular Component Size Organelle Organization Ephrin Receptor Signaling Pathway