WASF1 and BRK1

Number of citations: 0 (PubMedID 12181570)
Data Source: HPRD (in vitro, in vivo)

		WASF1	BRK1
Name		WASP family member 1	BRICK1 subunit of SCAR/WAVE actin nucleating complex
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton Focal Adhesion Actin Cytoskeleton Lamellipodium SCAR Complex Dendrite Cytoplasm Protein-containing Complex Synapse Anchoring Junction Postsynapse	Cytoplasm Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Arp2/3 Complex Binding	Protein Binding Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Receptor-mediated Endocytosis Mitochondrion Organization Rac Protein Signal Transduction Actin Cytoskeleton Organization Actin Filament Polymerization Neuron Projection Development Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein-containing Complex Assembly Lamellipodium Morphogenesis Dendrite Extension Modification Of Postsynaptic Actin Cytoskeleton Dendritic Transport Of Mitochondrion Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	In Utero Embryonic Development Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Actin Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Cell Motility Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
GWAS		No GWAS studies recorded	Arterial stiffness index ( 31235810 )
Novel Interactors		1 novel interactors: MMS22L	None recorded
Interacting Genes		38 interacting genes: ABI1 ABI3 ABL1 ACTB ACTG1 ACTR2 BAD BRK1 CCDC196 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP EFHC1 FYN GNAI1 GRB2 HSF2BP IFT20 IL12A ING5 LMO2 MAPKAPK2 NCK1 NCK2 NCKAP1 NYAP2 OSTF1 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRAF2 TRIP10	9 interacting genes: BRAP CYFIP2 MRFAP1 NCK1 NCKAP1 NDEL1 PFDN1 PIK3R3 WASF1
Entrez ID		8936	55845
HPRD ID		05434	12818
Ensembl ID		ENSG00000112290	ENSG00000254999
Uniprot IDs		Q92558	Q8WUW1
PDB IDs		3P8C 4N78 7USC 7USD 7USE	3P8C 4N78 7USC 7USD 7USE
GO Terms Enriched among Interactors		Actin Cytoskeleton Organization Actin Filament-based Process Cell Motility Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization SCAR Complex Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Cytoskeleton Organization Lamellipodium Cell Migration Cell Projection Morphogenesis Regulation Of Supramolecular Fiber Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Actin Filament Polymerization Regulation Of Cell Projection Organization Regulation Of Lamellipodium Organization Regulation Of Protein-containing Complex Assembly Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Lamellipodium Assembly Ephrin Receptor Binding Positive Regulation Of Cell Projection Organization Cell Projection Assembly Neuron Projection Morphogenesis Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Adhesion Positive Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Adhesion Positive Regulation Of Lamellipodium Organization Signaling Adaptor Activity Positive Regulation Of Protein Polymerization Regulation Of Cell Projection Assembly Lamellipodium Organization Establishment Or Maintenance Of Cell Polarity Phosphotyrosine Residue Binding Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cellular Component Size Organelle Organization Ephrin Receptor Signaling Pathway	SCAR Complex Regulation Of Supramolecular Fiber Organization Lamellipodium Organization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Filament Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Neuron Projection Extension Dendrite Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Actin Nucleation Regulation Of Actin Filament-based Process Developmental Cell Growth Regulation Of Actin Filament Polymerization Developmental Growth Involved In Morphogenesis Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Rac Protein Signal Transduction Positive Regulation Of Supramolecular Fiber Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Cell Projection Organization Regulation Of Actin Nucleation Lamellipodium Assembly Regulation Of Cellular Component Size Positive Regulation Of Actin Filament Polymerization Small GTPase-mediated Signal Transduction Cell Projection Morphogenesis Small GTPase Binding Regulation Of Cellular Component Organization Intracellular Signaling Cassette Cell Projection Assembly Cell Migration Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cell Projection Organization Insulin Receptor Signaling Pathway Developmental Growth Axo-dendritic Transport Positive Regulation Of Protein Polymerization Organelle Transport Along Microtubule Dendritic Transport Of Mitochondrion Zygotic Determination Of Anterior/posterior Axis, Embryo Basal Protein Localization Neurofilament Cytoskeleton Regulation Of Protein-containing Complex Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Positive Regulation Of Cap-independent Translational Initiation Eukaryotic Initiation Factor EIF2 Binding