WASF1 and NCKAP1

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (biochemical)
HPRD (in vitro, in vivo)

		WASF1	NCKAP1
Description		WASP family member 1	NCK associated protein 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton Focal Adhesion Actin Cytoskeleton Lamellipodium SCAR Complex Dendrite Cytoplasm Protein-containing Complex Synapse Anchoring Junction Postsynapse	Ruffle Cytosol Plasma Membrane Focal Adhesion Membrane Lamellipodium SCAR Complex Lamellipodium Membrane Filamentous Actin Cell Projection Extracellular Exosome Postsynapse
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Arp2/3 Complex Binding	Protein Binding Small GTPase Binding
	Biological Process	Receptor-mediated Endocytosis Mitochondrion Organization Rac Protein Signal Transduction Actin Cytoskeleton Organization Actin Filament Polymerization Neuron Projection Development Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein-containing Complex Assembly Lamellipodium Morphogenesis Dendrite Extension Modification Of Postsynaptic Actin Cytoskeleton Dendritic Transport Of Mitochondrion Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Cell Morphogenesis In Utero Embryonic Development Somitogenesis Neural Tube Closure Apoptotic Process Zygotic Determination Of Anterior/posterior Axis, Embryo Central Nervous System Development Endoderm Development Mesodermal Cell Migration Embryonic Body Morphogenesis Positive Regulation Of Lamellipodium Assembly Cell Migration Rac Protein Signal Transduction Cell Projection Assembly Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Notochord Development Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Protein Localization Embryonic Heart Tube Development Cell Migration Involved In Gastrulation Basal Protein Localization Apical Protein Localization Paraxial Mesoderm Development Paraxial Mesoderm Morphogenesis Notochord Morphogenesis Embryonic Foregut Morphogenesis Neuron Projection Morphogenesis Protein Stabilization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS			Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		38 interacting genes: ABI1 ABI3 ABL1 ACTB ACTG1 ACTR2 BAD BRK1 CCDC196 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP EFHC1 FYN GNAI1 GRB2 HSF2BP IFT20 IL12A ING5 LMO2 MAPKAPK2 NCK1 NCK2 NCKAP1 NYAP2 OSTF1 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRAF2 TRIP10	16 interacting genes: ABI1 BRK1 CYFIP2 DNMBP GAS7 MYO16 NCK1 NYAP1 NYAP2 RAC1 SPP1 TMEM132D WASF1 WASF2 WEE2-AS1 YWHAG
Entrez ID		8936	10787
HPRD ID		05434	05353
Ensembl ID		ENSG00000112290	ENSG00000061676
Uniprot IDs		Q92558	A0A994J4I5 A0A994J6K9 Q9Y2A7
PDB IDs		3P8C 4N78 7USC 7USD 7USE	3P8C 4N78 7USC 7USD 7USE
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Cell Motility Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization SCAR Complex Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Cytoskeleton Organization Lamellipodium Cell Migration Cell Projection Morphogenesis Regulation Of Supramolecular Fiber Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Actin Filament Polymerization Regulation Of Cell Projection Organization Regulation Of Lamellipodium Organization Regulation Of Protein-containing Complex Assembly Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Lamellipodium Assembly Ephrin Receptor Binding Positive Regulation Of Cell Projection Organization Cell Projection Assembly Neuron Projection Morphogenesis Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Adhesion Positive Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Adhesion Positive Regulation Of Lamellipodium Organization Signaling Adaptor Activity Positive Regulation Of Protein Polymerization Regulation Of Cell Projection Assembly Lamellipodium Organization Establishment Or Maintenance Of Cell Polarity Phosphotyrosine Residue Binding Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cellular Component Size Organelle Organization Ephrin Receptor Signaling Pathway	SCAR Complex Cell Projection Morphogenesis Cell Projection Organization Lamellipodium Organization Rac Protein Signal Transduction Lamellipodium Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Filament Organization Neuron Projection Morphogenesis Positive Regulation Of Actin Nucleation Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Anatomical Structure Morphogenesis Positive Regulation Of Lamellipodium Assembly Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin Filament Organization Positive Regulation Of Lamellipodium Organization Regulation Of Actin Nucleation Lamellipodium Assembly Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Intracellular Signaling Cassette Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Intracellular Signal Transduction Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Synapse Regulation Of Lamellipodium Organization Cell Projection Assembly Actin Polymerization Or Depolymerization Signal Transduction Dendrite Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway Supramolecular Fiber Organization Regulation Of Cellular Component Size Positive Regulation Of Organelle Organization Arp2/3 Complex Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Filament Polymerization Megakaryocyte Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding
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