WASF1 and NCKAP1

Number of citations of the paper that reports this interaction (PMID 12181570)
186

Data Source:
HPRD (in vitro, in vivo)

		WASF1	NCKAP1
Gene Name		WAS protein family, member 1	NCK-associated protein 1
Image
Gene Ontology Annotations	Cellular Component	Cytoskeleton Actin Cytoskeleton Cell Junction SCAR Complex Synapse	Cytosol Focal Adhesion Integral Component Of Membrane SCAR Complex Lamellipodium Membrane Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding Protein Complex Binding Rac GTPase Binding	Protein Binding Protein Complex Binding Rac GTPase Binding
	Biological Process	Protein Complex Assembly Movement Of Cell Or Subcellular Component Rac Protein Signal Transduction Actin Filament Polymerization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	In Utero Embryonic Development Somitogenesis Neural Tube Closure Apoptotic Process Zygotic Determination Of Anterior/posterior Axis, Embryo Central Nervous System Development Endoderm Development Mesodermal Cell Migration Embryonic Body Morphogenesis Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Lamellipodium Assembly Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Protein Localization Embryonic Heart Tube Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cell Migration Involved In Gastrulation Innate Immune Response Basal Protein Localization Apical Protein Localization Vascular Endothelial Growth Factor Receptor Signaling Pathway Paraxial Mesoderm Morphogenesis Notochord Morphogenesis Embryonic Foregut Morphogenesis Protein Stabilization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: ABI1 ABL1 ACTB ACTG1 ACTR2 BAD BAIAP2 BRK1 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP FYN GNAI1 GRB2 IFT20 IL12A NCK1 NCKAP1 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRIP10	11 interactors: ABI1 BRK1 CYFIP2 DNMBP GAS7 NCK1 RAC1 SPP1 WASF1 WASF2 YWHAG
Entrez ID		8936	10787
HPRD ID		05434	05353
Ensembl ID		ENSG00000112290	ENSG00000061676
Uniprot IDs		Q92558	Q9Y2A7
PDB IDs		3P8C	3P8C
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc Receptor Signaling Pathway Endocytosis Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Vesicle-mediated Transport Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Defense Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune System Process Actin Cytoskeleton Organization Actin Filament-based Process Immune System Process Response To Stress Signaling Blood Coagulation Cell Communication Hemostasis Movement Of Cell Or Subcellular Component Signal Transduction Regulation Of Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Transport Cellular Response To Stimulus Regulation Of Body Fluid Levels Locomotion Wound Healing Cell Projection Morphogenesis Cell Part Morphogenesis Cytoskeleton Organization Cell Projection Organization Response To Stimulus Response To Wounding Axonogenesis Axon Guidance Ephrin Receptor Signaling Pathway Axon Development	Vascular Endothelial Growth Factor Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Cytoskeleton Organization Actin Filament-based Process Lamellipodium Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Lamellipodium Assembly Actin Polymerization Or Depolymerization Positive Regulation Of Lamellipodium Organization Rac Protein Signal Transduction Actin Filament Organization Cytoskeleton Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Immune Response Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Actin Cytoskeleton Organization Defense Response Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Innate Immune Response Actin Filament Polymerization Regulation Of Immune Response Movement Of Cell Or Subcellular Component Lamellipodium Assembly Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Cytoskeleton Organization Lamellipodium Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Positive Regulation Of Cellular Component Biogenesis Immune Response Regulation Of Immune System Process Organelle Organization Immune System Process Cellular Protein Complex Assembly Protein Polymerization Vesicle-mediated Transport Regulation Of Cell Projection Assembly Cell Projection Morphogenesis
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