WASF1 and SRGAP3

Number of citations of the paper that reports this interaction (PubMedID 12447388)
0

Data Source:
HPRD (in vitro, in vivo)

		WASF1	SRGAP3
Description		WASP family member 1	SLIT-ROBO Rho GTPase activating protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton Focal Adhesion Actin Cytoskeleton Lamellipodium SCAR Complex Dendrite Cytoplasm Protein-containing Complex Synapse Anchoring Junction Postsynapse	Cytosol Synapse Postsynapse
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Arp2/3 Complex Binding	GTPase Activator Activity Protein Binding
	Biological Process	Receptor-mediated Endocytosis Mitochondrion Organization Rac Protein Signal Transduction Actin Cytoskeleton Organization Actin Filament Polymerization Neuron Projection Development Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein-containing Complex Assembly Lamellipodium Morphogenesis Dendrite Extension Modification Of Postsynaptic Actin Cytoskeleton Dendritic Transport Of Mitochondrion Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Signal Transduction Nervous System Development Negative Regulation Of Cell Migration Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Synapse Assembly
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Inactivation of CDC42 and RAC1 CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS			3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Body fat percentage ( 31752434) Lead levels in blood ( 25820613) Rapid automised naming of letters ( 30741946)
Interacting Genes		38 interacting genes: ABI1 ABI3 ABL1 ACTB ACTG1 ACTR2 BAD BRK1 CCDC196 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP EFHC1 FYN GNAI1 GRB2 HSF2BP IFT20 IL12A ING5 LMO2 MAPKAPK2 NCK1 NCK2 NCKAP1 NYAP2 OSTF1 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRAF2 TRIP10	11 interacting genes: DISC1 DTNBP1 ENKD1 FASLG KDM1A PRMT6 RAC1 SMARCC2 SUV39H1 TNIK WASF1
Entrez ID		8936	9901
HPRD ID		05434	12108
Ensembl ID		ENSG00000112290	ENSG00000196220
Uniprot IDs		Q92558	O43295
PDB IDs		3P8C 4N78 7USC 7USD 7USE
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Cell Motility Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization SCAR Complex Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Cytoskeleton Organization Lamellipodium Cell Migration Cell Projection Morphogenesis Regulation Of Supramolecular Fiber Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Actin Filament Polymerization Regulation Of Cell Projection Organization Regulation Of Lamellipodium Organization Regulation Of Protein-containing Complex Assembly Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Lamellipodium Assembly Ephrin Receptor Binding Positive Regulation Of Cell Projection Organization Cell Projection Assembly Neuron Projection Morphogenesis Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Adhesion Positive Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Adhesion Positive Regulation Of Lamellipodium Organization Signaling Adaptor Activity Positive Regulation Of Protein Polymerization Regulation Of Cell Projection Assembly Lamellipodium Organization Establishment Or Maintenance Of Cell Polarity Phosphotyrosine Residue Binding Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cellular Component Size Organelle Organization Ephrin Receptor Signaling Pathway	Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Developmental Process Regulation Of Dendritic Spine Development Cytoskeleton Organization Cell Projection Morphogenesis Cell Projection Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Projection Organization Actin Cytoskeleton Organization Cell Projection Assembly Cerebral Cortex Radially Oriented Cell Migration Regulation Of Signal Transduction Regulation Of Anatomical Structure Morphogenesis Regulation Of Multicellular Organismal Development Rac Protein Signal Transduction Regulation Of Cell Development Actin Filament-based Process Regulation Of Postsynapse Organization Histone H3 Methyltransferase Activity Regulation Of Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Neuroblast Proliferation Cerebral Cortex Cell Migration Actin Filament Polymerization Histone Methyltransferase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Telencephalon Cell Migration Lamellipodium Organization Glutamatergic Synapse Regulation Of DNA Repair Regulation Of Neuroblast Proliferation Ciliary Base Forebrain Cell Migration Dendrite Morphogenesis Developmental Process Positive Regulation Of Neural Precursor Cell Proliferation Non-motile Cilium Assembly Cilium Assembly Neuron Projection Morphogenesis Chromatin Remodeling Establishment Of Organelle Localization Wnt Signaling Pathway Actin Polymerization Or Depolymerization Histone H2AR3 Methyltransferase Activity
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