CPNE1 and SORBS3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CPNE1	SORBS3
Description		copine 1	sorbin and SH3 domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Membrane Azurophil Granule Membrane Extracellular Exosome	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell-substrate Junction Anchoring Junction
	Molecular Function	Phosphatidylserine Binding Endopeptidase Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding Metal Ion Binding NF-kappaB Binding	Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding
	Biological Process	Proteolysis Lipid Metabolic Process Negative Regulation Of Gene Expression Vesicle-mediated Transport Cell Differentiation Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA Binding Positive Regulation Of Neuron Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Calcium Ion Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Neuron Projection Extension	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Cytoskeleton Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways		Glycerophospholipid biosynthesis Neutrophil degranulation	Smooth Muscle Contraction
Drugs		Theophylline
Diseases
GWAS		Blood protein levels ( 30072576) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)
Interacting Genes		22 interacting genes: ACTB BCOR BUB3 CCDC22 CEBPA CPNE4 LHX6 LIG4 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SNCA SORBS3 SPTBN1 STK3 UBE2M UBE2O WTAP	137 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AIRIM AKIRIN2 AKT2 ANKS1A ARNT2 ATOSB CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CFTR CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DRC4 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM53C FASLG FBXL19 FLOT1 FNDC11 FXR1 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SHANK3 SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSC1 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414
Entrez ID		8904	10174
HPRD ID		05014	11535
Ensembl ID		ENSG00000214078	ENSG00000120896
Uniprot IDs		B0QZ18 Q99829	O60504
PDB IDs			2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Regulation Of Norepinephrine Uptake Cellular Response To Metal Ion Response To Metal Ion Transporter Regulator Activity Tau Protein Binding Regulation Of Protein Localization To Cell Periphery Protein-containing Complex Nucleus Regulation Of Organelle Organization Protein-containing Complex Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apical Protein Localization Cellular Response To Lithium Ion Magnesium Ion Binding Protein Domain Specific Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Response To Lithium Ion MAPK Cascade Regulation Of Early Endosome To Late Endosome Transport Structural Constituent Of Cytoskeleton Regulation Of Apoptotic Process Cytoskeleton Regulation Of Programmed Cell Death Nucleoplasm Regulation Of Cellular Component Organization Cortical Cytoskeleton Glutamatergic Synapse Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Receptor Localization To Synapse Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Differentiation Cell Development Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Developmental Process Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Establishment Of Integrated Proviral Latency Central Nervous System Development Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Actin Filament Capping Negative Regulation Of Actin Filament Depolymerization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly	Protein Binding Cytoskeleton Cytoplasm SH3 Domain Binding Adherens Junction Organization Adherens Junction Assembly Regulation Of Actin Cytoskeleton Organization Identical Protein Binding Regulation Of Actin Filament Organization Bergmann Glial Cell Differentiation Regulation Of Actin Filament-based Process Motile Cilium Zonula Adherens Assembly Protein Domain Specific Binding Regulation Of Cytoskeleton Organization Positive Regulation Of Cap-dependent Translational Initiation Interleukin-34-mediated Signaling Pathway Nucleus Glial Cell Differentiation Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase III Regulation Of Golgi Inheritance Centriole Cell Projection
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?