KRIT1 and RAP1A

Number of citations of the paper that reports this interaction (PMID 9285558)
49

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KRIT1	RAP1A
Gene Name		KRIT1, ankyrin repeat containing	RAP1A, member of RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Microtubule Plasma Membrane Cell-cell Junction	Cytoplasm Early Endosome Late Endosome Cytosol Plasma Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Small GTPase Regulator Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding Protein Complex Binding	GTPase Activity Protein Binding GTP Binding Protein Transporter Activity Ras GTPase Binding Rap Guanyl-nucleotide Exchange Factor Activity Protein Complex Binding
	Biological Process	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Small GTPase Mediated Signal Transduction Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Protein Binding Cell Redox Homeostasis Regulation Of Catalytic Activity Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process	Activation Of MAPKK Activity Energy Reserve Metabolic Process Signal Transduction Blood Coagulation Positive Regulation Of Neuron Projection Development Protein Transport Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Nerve Growth Factor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis
Pathways			Signalling to ERKs Signalling by NGF Prolonged ERK activation events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling NGF signalling via TRKA from the plasma membrane GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) ARMS-mediated activation Rap1 signalling Platelet activation, signaling and aggregation Frs2-mediated activation Adaptive Immune System
Drugs
Diseases
GWAS			Osteoporosis ( 20548944)
Protein-Protein Interactions		6 interactors: FAS ITGB1BP1 PLCB3 RAP1A RGS4 TRPV4	41 interactors: APBB1IP ARHGEF1 BIN1 BMX BRAF FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A KRIT1 MLLT4 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALA RALGDS RAP1GAP RAP1GDS1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA4 TCEB3 TNFRSF10C
Entrez ID		889	5906
HPRD ID		05020	01545
Ensembl ID		ENSG00000001631	ENSG00000116473
Uniprot IDs		A4D1F7 O00522	A8KAH9 P62834
PDB IDs		3U7D 4DX8 4DXA 4HDO 4HDQ 4JIF	1C1Y 1GUA 3KUC
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Junction Assembly Positive Regulation Of Catalytic Activity Cortical Microtubule Organization Osmosensory Signaling Pathway Regulation Of Cell Differentiation Regulation Of MAPK Cascade Vasopressin Secretion Motor Neuron Apoptotic Process Energy Reserve Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of MAPK Cascade Regulation Of GTPase Activity Regulation Of Kinase Activity Regulation Of Cell Development Regulation Of Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Positive Regulation Of Microtubule Depolymerization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Protein Kinase Activity Response To Mechanical Stimulus Regulation Of Catalytic Activity Negative Regulation Of Kinase Activity Negative Regulation Of Protein Targeting To Membrane Necroptotic Signaling Pathway Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Protein Complex Assembly Positive Regulation Of Hydrolase Activity Regulation Of Protein Phosphorylation Integrin Activation Transformed Cell Apoptotic Process Activation-induced Cell Death Of T Cells Negative Regulation Of Fibroblast Migration Myoblast Migration Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Response To Osmotic Stress Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Hyperosmotic Salinity Response Inflammatory Cell Apoptotic Process Negative Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Hyperoxia Positive Regulation Of Protein Homooligomerization Rap Protein Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Transferase Activity	Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Rap GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Regulation Of Ras GTPase Activity Regulation Of Rap GTPase Activity Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Regulation Of Rap Protein Signal Transduction Signal Transduction Cell Communication Regulation Of Metabolic Process Cellular Response To Stimulus Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Ras Protein Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Apoptotic Process Regulation Of Cell Death Cell Activation Regulation Of Protein Kinase Activity Negative Regulation Of Signaling Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Platelet Activation Regulation Of Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Lyase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Differentiation
Tagcloud ?		abstract assisted bm desorption flight foxo1 h2o2 hbm immunoblot improves ionization krev maldi migratory modulates modulator mscs pretreated protects proteomic qpcr rap1 ros sod2 tof trapped trophic valproic vpa	bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa
Tagcloud (Difference) ?		abstract assisted bm desorption flight foxo1 h2o2 hbm immunoblot improves ionization krev maldi migratory modulates modulator mscs pretreated protects proteomic qpcr ros sod2 tof trapped trophic valproic vpa	bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa
Tagcloud (Intersection) ?		rap1