KRIT1 and RGS4

Number of citations of the paper that reports this interaction (PMID 10747990)
29

Data Source:
BioGRID (pull down, unspecified method)

		KRIT1	RGS4
Gene Name		KRIT1, ankyrin repeat containing	regulator of G-protein signaling 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Microtubule Plasma Membrane Cell-cell Junction	Cytoplasm Cytosol Plasma Membrane Protein Complex
	Molecular Function	Small GTPase Regulator Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding Protein Complex Binding	G-protein Alpha-subunit Binding GTPase Activator Activity Calmodulin Binding
	Biological Process	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Small GTPase Mediated Signal Transduction Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Protein Binding Cell Redox Homeostasis Regulation Of Catalytic Activity Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process	Inactivation Of MAPK Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways			Signaling by GPCR GPCR downstream signaling G alpha (z) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: FAS ITGB1BP1 PLCB3 RAP1A RGS4 TRPV4	12 interactors: CALM1 COPB1 COPB2 ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KRIT1 PLCB1 PTAFR
Entrez ID		889	5999
HPRD ID		05020	03947
Ensembl ID		ENSG00000001631	ENSG00000117152
Uniprot IDs		A4D1F7 O00522	P49798
PDB IDs		3U7D 4DX8 4DXA 4HDO 4HDQ 4JIF
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Junction Assembly Positive Regulation Of Catalytic Activity Cortical Microtubule Organization Osmosensory Signaling Pathway Regulation Of Cell Differentiation Regulation Of MAPK Cascade Vasopressin Secretion Motor Neuron Apoptotic Process Energy Reserve Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of MAPK Cascade Regulation Of GTPase Activity Regulation Of Kinase Activity Regulation Of Cell Development Regulation Of Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Positive Regulation Of Microtubule Depolymerization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Protein Kinase Activity Response To Mechanical Stimulus Regulation Of Catalytic Activity Negative Regulation Of Kinase Activity Negative Regulation Of Protein Targeting To Membrane Necroptotic Signaling Pathway Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Protein Complex Assembly Positive Regulation Of Hydrolase Activity Regulation Of Protein Phosphorylation Integrin Activation Transformed Cell Apoptotic Process Activation-induced Cell Death Of T Cells Negative Regulation Of Fibroblast Migration Myoblast Migration Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Response To Osmotic Stress Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Hyperosmotic Salinity Response Inflammatory Cell Apoptotic Process Negative Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Hyperoxia Positive Regulation Of Protein Homooligomerization Rap Protein Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Transferase Activity	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Inositol Phosphate Metabolic Process Platelet Activation Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Cyclase Activity Synaptic Transmission Wound Healing Regulation Of CAMP Biosynthetic Process Signal Transduction Cell Activation Response To Wounding COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Regulation Of CAMP Metabolic Process G-protein Coupled Acetylcholine Receptor Signaling Pathway Golgi Vesicle Budding Signaling Cell Communication Regulation Of Phosphorus Metabolic Process Blood Coagulation Hemostasis Positive Regulation Of Catalytic Activity Cell-cell Signaling Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Cellular Response To Stimulus Vesicle Targeting, To, From Or Within Golgi Regulation Of Calcium Ion Transport Negative Regulation Of CAMP Metabolic Process Dopamine Receptor Signaling Pathway Intracellular Signal Transduction Vesicle Organization Regulation Of Body Fluid Levels Retrograde Vesicle-mediated Transport, Golgi To ER Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Calcium Ion Transport Vesicle Targeting Localization Within Membrane Regulation Of Phosphorylation Activation Of Phospholipase C Activity Intra-Golgi Vesicle-mediated Transport Regulation Of Protein Kinase Activity Positive Regulation Of Phospholipase C Activity
Tagcloud ?		abstract assisted bm desorption flight foxo1 h2o2 hbm immunoblot improves ionization krev maldi migratory modulates modulator mscs pretreated protects proteomic qpcr rap1 ros sod2 tof trapped trophic valproic vpa	102kspsklsp109 adenylyl anandamide anticipated arrestin1 beta3 cb1 conform contraction endowed engage erk1 galphai galphaq gbetagamma gi grk5 k215r minigene mlc myosin mypt1 ptx rhoa rip ser103 ser108 signaled uncoupling
Tagcloud (Difference) ?		abstract assisted bm desorption flight foxo1 h2o2 hbm immunoblot improves ionization krev maldi migratory modulates modulator mscs pretreated protects proteomic qpcr rap1 ros sod2 tof trapped trophic valproic vpa	102kspsklsp109 adenylyl anandamide anticipated arrestin1 beta3 cb1 conform contraction endowed engage erk1 galphai galphaq gbetagamma gi grk5 k215r minigene mlc myosin mypt1 ptx rhoa rip ser103 ser108 signaled uncoupling
Tagcloud (Intersection) ?