KRIT1

Name	KRIT1 ankyrin repeat containing
Structure
Novel Interactors	1 novel interactors: CDK6
Interactors	7 interactors: ITGB1BP1 PLCB3 RAP1A RGS4 TIAM1 TRPV4 UBE2K
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Membrane Protein-containing Complex Anchoring Junction
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding GTPase Regulator Activity
	Biological Process	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Endothelium Development Small GTPase-mediated Signal Transduction Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Integrin Activation Cell Redox Homeostasis Regulation Of Angiogenesis Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process
Diseases	Cerebral cavernous malformation
GWAS	Coffee consumption ( 31046077 ) Hippocampal volume in Alzheimer's disease dementia ( 29274321 )
Entrez ID	889
HPRD ID	05020
Ensembl ID	ENSG00000001631
Uniprot IDs	A4D1F7 O00522
PDB IDs	3U7D 4DX8 4DXA 4HDO 4HDQ 4JIF 4TKN 5D68 6OQ3 6OQ4 6UZK 8SU8 8T09 8T7V
GO Terms Enriched among Interactors ?	Signal Transduction Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex Regulation Of Cell Differentiation FBXO Family Protein Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Signaling Protein Polymerization Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Calmodulin Binding Calcium Ion Transmembrane Import Into Cytosol Regulation Of Neuron Projection Development Regulation Of ERK1 And ERK2 Cascade Response To Antineoplastic Agent Anchoring Junction Negative Regulation Of Glycine Import Across Plasma Membrane Protein Kinase Binding Regulation Of Supramolecular Fiber Organization Osmosensor Activity Blood Vessel Endothelial Cell Delamination Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Stretch-activated, Monoatomic Cation-selective, Calcium Channel Activity Kinase Binding Ruffle Positive Regulation Of Cellular Component Organization Cell-matrix Adhesion Notch Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Dopamine Receptor Signaling Pathway Cellular Hypotonic Salinity Response Vasopressin Secretion Regulation Of Cell-matrix Adhesion Epithelial Cell Development Positive Regulation Of Cell-substrate Adhesion Protein-containing Complex Assembly Positive Regulation Of Protein Kinase Activity