KRIT1 and PLCB3

Number of citations of the paper that reports this interaction (PMID 12821674)
5

Data Source:
BioGRID (pull down, affinity chromatography technology)

		KRIT1	PLCB3
Gene Name		KRIT1, ankyrin repeat containing	phospholipase C, beta 3 (phosphatidylinositol-specific)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Microtubule Plasma Membrane Cell-cell Junction	Nucleoplasm Cytosol Membrane Protein Complex
	Molecular Function	Small GTPase Regulator Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding Protein Complex Binding	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Signal Transducer Activity Calcium Ion Binding Calmodulin Binding
	Biological Process	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Small GTPase Mediated Signal Transduction Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Protein Binding Cell Redox Homeostasis Regulation Of Catalytic Activity Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process	Regulation Of Systemic Arterial Blood Pressure Synaptic Transmission Lipid Catabolic Process Intracellular Signal Transduction Inositol Phosphate Metabolic Process Small Molecule Metabolic Process
Pathways			G alpha (q) signalling events Signaling by GPCR Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Integration of energy metabolism G beta:gamma signalling through PLC beta Signaling by Wnt Synthesis of IP3 and IP4 in the cytosol Gastrin-CREB signalling pathway via PKC and MAPK Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell PLC beta mediated events G-protein beta:gamma signalling Opioid Signalling Regulation of insulin secretion G-protein mediated events Activation of Kainate Receptors upon glutamate binding Inositol phosphate metabolism beta-catenin independent WNT signaling Presynaptic function of Kainate receptors G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Ca2+ pathway Free fatty acids regulate insulin secretion Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: FAS ITGB1BP1 PLCB3 RAP1A RGS4 TRPV4	13 interactors: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 PARD3 PARD6A PRKG1 PRKG2 RGS12 SLC9A3R2 TRPC3 TRPM7
Entrez ID		889	5331
HPRD ID		05020	02577
Ensembl ID		ENSG00000001631	ENSG00000149782
Uniprot IDs		A4D1F7 O00522	Q01970
PDB IDs		3U7D 4DX8 4DXA 4HDO 4HDQ 4JIF	3OHM 4GNK
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Junction Assembly Positive Regulation Of Catalytic Activity Cortical Microtubule Organization Osmosensory Signaling Pathway Regulation Of Cell Differentiation Regulation Of MAPK Cascade Vasopressin Secretion Motor Neuron Apoptotic Process Energy Reserve Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of MAPK Cascade Regulation Of GTPase Activity Regulation Of Kinase Activity Regulation Of Cell Development Regulation Of Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Positive Regulation Of Microtubule Depolymerization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Protein Kinase Activity Response To Mechanical Stimulus Regulation Of Catalytic Activity Negative Regulation Of Kinase Activity Negative Regulation Of Protein Targeting To Membrane Necroptotic Signaling Pathway Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Protein Complex Assembly Positive Regulation Of Hydrolase Activity Regulation Of Protein Phosphorylation Integrin Activation Transformed Cell Apoptotic Process Activation-induced Cell Death Of T Cells Negative Regulation Of Fibroblast Migration Myoblast Migration Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Response To Osmotic Stress Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Hyperosmotic Salinity Response Inflammatory Cell Apoptotic Process Negative Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Hyperoxia Positive Regulation Of Protein Homooligomerization Rap Protein Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Transferase Activity	Regulation Of Calcium Ion Transport Protein Autophosphorylation Regulation Of Skeletal Muscle Adaptation Wound Healing Calcium Ion Transport Response To Wounding Signal Transduction Negative Regulation Of Peptidyl-threonine Phosphorylation Blood Coagulation Hemostasis Signaling Cell Communication Nitric Oxide Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cellular Response To Heat Reactive Nitrogen Species Metabolic Process Regulation Of Nitric-oxide Synthase Activity Regulation Of Body Fluid Levels Phosphorylation Regulation Of Ion Transport Tight Junction Assembly Cellular Response To Stimulus Protein Phosphorylation System Development Inhibitory G-protein Coupled Receptor Phosphorylation Cellular Response To Heat Response To Metal Ion Nervous System Development Apical Junction Assembly Regulation Of Oxidoreductase Activity Metal Ion Transport Regulation Of Calcium Ion Transport Into Cytosol Response To Stress Pharynx Development Activation Of Meiosis Involved In Egg Activation Positive Regulation Of Calcium Ion Transport Multicellular Organismal Development Phototransduction Response To Organic Substance Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Anatomical Structure Development Detection Of Light Stimulus Response To Heat Reactive Oxygen Species Metabolic Process Regulation Of Cellular Process Response To Calcium Ion Peptidyl-serine Phosphorylation Cell-cell Junction Assembly Response To Inorganic Substance Interferon-gamma-mediated Signaling Pathway
Tagcloud ?		abstract assisted bm desorption flight foxo1 h2o2 hbm immunoblot improves ionization krev maldi migratory modulates modulator mscs pretreated protects proteomic qpcr rap1 ros sod2 tof trapped trophic valproic vpa	calpain candidate candidates capn1 chuk compelling consideration defect disorder distally encode fatal harlequin hi ichq ichthyosis ikka keratinocytes locus mapping mutational narrowed phospholipase r433p refined rela scaling similarities unrelated
Tagcloud (Difference) ?		abstract assisted bm desorption flight foxo1 h2o2 hbm immunoblot improves ionization krev maldi migratory modulates modulator mscs pretreated protects proteomic qpcr rap1 ros sod2 tof trapped trophic valproic vpa	calpain candidate candidates capn1 chuk compelling consideration defect disorder distally encode fatal harlequin hi ichq ichthyosis ikka keratinocytes locus mapping mutational narrowed phospholipase r433p refined rela scaling similarities unrelated
Tagcloud (Intersection) ?