TKT

Gene Name		transketolase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Peroxisome Cytosol Vesicle Extracellular Vesicular Exosome
	Molecular Function	Transketolase Activity Protein Homodimerization Activity Metal Ion Binding Cofactor Binding
	Biological Process	Carbohydrate Metabolic Process Xylulose Biosynthetic Process Pentose-phosphate Shunt Energy Reserve Metabolic Process Pentose-phosphate Shunt, Non-oxidative Branch Pathogenesis Regulation Of Growth Small Molecule Metabolic Process Glyceraldehyde-3-phosphate Biosynthetic Process
Pathways		Integration of energy metabolism Insulin effects increased synthesis of Xylulose-5-Phosphate Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates Pentose phosphate pathway (hexose monophosphate shunt)
Drugs
Diseases
GWAS		Ventricular conduction ( 21076409)
Protein-protein Interactions		3 interactors: MYOC SQSTM1 TERF1
Entrez ID		7086
HPRD ID		06001
Ensembl ID		ENSG00000163931
Uniprot IDs		P29401
PDB IDs		3MOS 3OOY 4KXU 4KXV 4KXW 4KXX 4KXY
Enriched GO Terms of Interacting Partners?		ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy Positive Regulation Of Cytoskeleton Organization ERBB2 Signaling Pathway Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Positive Regulation Of Cellular Component Biogenesis Non-canonical Wnt Signaling Pathway Via JNK Cascade Negative Regulation Of Telomere Maintenance Via Telomerase Non-canonical Wnt Signaling Pathway Via MAPK Cascade Positive Regulation Of Organelle Organization Clustering Of Voltage-gated Sodium Channels Protein Oligomerization Replicative Cell Aging Skeletal Muscle Adaptation Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cytoskeleton Organization Neuronal Ion Channel Clustering Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Microtubule Polymerization Positive Regulation Of Apoptotic Process Positive Regulation Of Macroautophagy Regulation Of Telomerase Activity Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Mitochondrial Depolarization Regulation Of Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Muscle Hypertrophy Regulation Of Microtubule Polymerization Neuron Maturation Telomere Maintenance Via Telomere Lengthening Non-canonical Wnt Signaling Pathway Regulation Of Substrate Adhesion-dependent Cell Spreading
Tagcloud ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 topbp1 znf668