TKT

Description		transketolase
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Peroxisome Endoplasmic Reticulum Membrane Cytosol Nuclear Body Vesicle Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Transketolase Activity Calcium Ion Binding Protein Binding Transferase Activity Transketolase Or Transaldolase Activity Thiamine Pyrophosphate Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Pentose-phosphate Shunt Pentose-phosphate Shunt, Non-oxidative Branch Glyceraldehyde-3-phosphate Metabolic Process Regulation Of Growth Glyceraldehyde-3-phosphate Biosynthetic Process D-xylulose 5-phosphate Biosynthetic Process
Pathways		Insulin effects increased synthesis of Xylulose-5-Phosphate Pentose phosphate pathway NFE2L2 regulates pentose phosphate pathway genes
Drugs		Copper
Diseases
GWAS		A body shape index ( 34021172) Body mass index ( 26426971) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) QRS duration ( 27577874 27659466 30012220) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		8 interacting genes: CEBPA FNDC3B ITGB1BP2 LINC01554 MYOC SERPINB5 SQSTM1 TERF1
Entrez ID		7086
HPRD ID		06001
Ensembl ID		ENSG00000163931
Uniprot IDs		P29401 V9HWD9
PDB IDs		3MOS 3OOY 4KXU 4KXV 4KXW 4KXX 4KXY 6HA3 6HAD 6RJB 8WA8 8WA9 8WAA
Enriched GO Terms of Interacting Partners?		Fat Cell Proliferation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Energy Homeostasis Receptor Tyrosine Kinase Binding Skeletal Muscle Hypertrophy Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Response To Vitamin B2 C/EBP Complex Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Brown Fat Cell Proliferation Amphisome CHOP-C/EBP Complex
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