TKT and MYOC

Number of citations of the paper that reports this interaction (PMID 16289162)
20

Data Source:
BioGRID (far western blotting)
HPRD (in vitro)

		TKT	MYOC
Gene Name		transketolase	myocilin, trabecular meshwork inducible glucocorticoid response
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Peroxisome Cytosol Vesicle Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Cytoplasmic Vesicle Node Of Ranvier Extracellular Vesicular Exosome
	Molecular Function	Transketolase Activity Protein Homodimerization Activity Metal Ion Binding Cofactor Binding	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding
	Biological Process	Carbohydrate Metabolic Process Xylulose Biosynthetic Process Pentose-phosphate Shunt Energy Reserve Metabolic Process Pentose-phosphate Shunt, Non-oxidative Branch Pathogenesis Regulation Of Growth Small Molecule Metabolic Process Glyceraldehyde-3-phosphate Biosynthetic Process	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Integration of energy metabolism Insulin effects increased synthesis of Xylulose-5-Phosphate Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates Pentose phosphate pathway (hexose monophosphate shunt)
Drugs
Diseases
GWAS		Ventricular conduction ( 21076409)
Protein-Protein Interactions		3 interactors: MYOC SQSTM1 TERF1	40 interactors: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 TGFBR1 TIMP1 TKT TNFRSF1A
Entrez ID		7086	4653
HPRD ID		06001	03387
Ensembl ID		ENSG00000163931	ENSG00000034971
Uniprot IDs		P29401	Q99972
PDB IDs		3MOS 3OOY 4KXU 4KXV 4KXW 4KXX 4KXY
Enriched GO Terms of Interacting Partners?		ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy Positive Regulation Of Cytoskeleton Organization ERBB2 Signaling Pathway Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Positive Regulation Of Cellular Component Biogenesis Non-canonical Wnt Signaling Pathway Via JNK Cascade Negative Regulation Of Telomere Maintenance Via Telomerase Non-canonical Wnt Signaling Pathway Via MAPK Cascade Positive Regulation Of Organelle Organization Clustering Of Voltage-gated Sodium Channels Protein Oligomerization Replicative Cell Aging Skeletal Muscle Adaptation Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cytoskeleton Organization Neuronal Ion Channel Clustering Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Microtubule Polymerization Positive Regulation Of Apoptotic Process Positive Regulation Of Macroautophagy Regulation Of Telomerase Activity Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Mitochondrial Depolarization Regulation Of Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Muscle Hypertrophy Regulation Of Microtubule Polymerization Neuron Maturation Telomere Maintenance Via Telomere Lengthening Non-canonical Wnt Signaling Pathway Regulation Of Substrate Adhesion-dependent Cell Spreading	Extracellular Matrix Organization Extracellular Structure Organization Platelet Activation Extracellular Matrix Disassembly Cell Activation Response To Wounding Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Cardiovascular System Development Collagen Fibril Organization System Development Developmental Process Blood Vessel Development Platelet Degranulation Multicellular Organismal Development Vasculature Development Glycolytic Process Organ Development Pyruvate Metabolic Process Pathogenesis Anatomical Structure Development Response To Stress Anatomical Structure Morphogenesis Monosaccharide Metabolic Process Carbohydrate Catabolic Process Locomotion Cell Development Glucose Metabolic Process Cell Differentiation Regulation Of Cellular Component Movement Vesicle-mediated Transport Response To Stimulus Movement Of Cell Or Subcellular Component Hexose Metabolic Process Immune System Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Skeletal System Development Platelet Aggregation Generation Of Precursor Metabolites And Energy Blood Vessel Morphogenesis Secretion Regulation Of Cell Motility Regulation Of Immune Response Organic Acid Metabolic Process Tissue Development Regulation Of Locomotion Cell Adhesion
Tagcloud ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 topbp1 znf668	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Difference) ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 topbp1 znf668	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Intersection) ?