RELN and VLDLR

Number of citations of the paper that reports this interaction (PMID 10571241)
136

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		RELN	VLDLR
Gene Name		reelin	very low density lipoprotein receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Dendrite	Plasma Membrane Coated Pit Membrane Integral Component Of Membrane Very-low-density Lipoprotein Particle Receptor Complex
	Molecular Function	Protein Serine/threonine/tyrosine Kinase Activity Serine-type Peptidase Activity Metal Ion Binding Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding	Glycoprotein Binding Low-density Lipoprotein Receptor Activity Calcium Ion Binding Protein Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Glycoprotein Transporter Activity Reelin Receptor Activity Calcium-dependent Protein Binding
	Biological Process	Cell Morphogenesis Involved In Differentiation Neuron Migration Proteolysis Cell Adhesion Axon Guidance Central Nervous System Development Brain Development Long-term Memory Associative Learning Glial Cell Differentiation Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Dendrite Development Peptidyl-tyrosine Phosphorylation Spinal Cord Patterning Ventral Spinal Cord Development Hippocampus Development Cerebral Cortex Tangential Migration Layer Formation In Cerebral Cortex Positive Regulation Of TOR Signaling Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Positive Regulation Of Protein Kinase Activity Response To Pain Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Behavior Regulation Of Synaptic Transmission Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Synapse Maturation N-methyl-D-aspartate Receptor Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Lateral Motor Column Neuron Migration Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Lateral Motor Column Neuron Migration Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Lipid Transport Receptor-mediated Endocytosis Signal Transduction Nervous System Development Memory Cholesterol Metabolic Process Ventral Spinal Cord Development Glycoprotein Transport Very-low-density Lipoprotein Particle Clearance Reelin-mediated Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Dendrite Development
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 20452100) Multiple sclerosis (age of onset) ( 19010793) Otosclerosis ( 19230858) Schizophrenia ( 18282107)	Alzheimer's disease (age of onset) ( 22005931) Gambling ( 22780124) Vascular endothelial growth factor levels ( 21757650)
Protein-Protein Interactions		6 interactors: DAB1 LRP8 PCDHA4 PCDHA6 SQSTM1 VLDLR	9 interactors: APOE CD36 CLU DAB1 LPL LRPAP1 MYLIP RELN SNX17
Entrez ID		5649	7436
HPRD ID		02742	01895
Ensembl ID		ENSG00000189056	ENSG00000147852
Uniprot IDs		P78509	P98155 Q5VVF5
PDB IDs			1V9U 3DPR
Enriched GO Terms of Interacting Partners?		Reelin-mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Nervous System Development Positive Regulation Of Neuron Differentiation Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Neuron Projection Development Ventral Spinal Cord Development Positive Regulation Of Dendrite Development Positive Regulation Of Neurogenesis Positive Regulation Of Protein Metabolic Process Cerebral Cortex Radially Oriented Cell Migration Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Developmental Process Regulation Of Cell Projection Organization Positive Regulation Of Kinase Activity Positive Regulation Of Cell Development Regulation Of Phosphorus Metabolic Process Cerebral Cortex Cell Migration Regulation Of Neuron Differentiation Positive Regulation Of Transferase Activity Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Ammon Gyrus Development Telencephalon Cell Migration Forebrain Cell Migration Regulation Of Dendrite Development Spinal Cord Development Regulation Of Neurogenesis Cerebellum Structural Organization Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Cerebral Cortex Development Regulation Of Kinase Activity Lateral Motor Column Neuron Migration Very-low-density Lipoprotein Particle Clearance Glycoprotein Transport Regulation Of Cell Development Positive Regulation Of Cell Differentiation System Development Regulation Of Protein Metabolic Process Spinal Cord Motor Neuron Migration Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Pallium Development Radial Glia Guided Migration Of Purkinje Cell Central Nervous System Development	Regulation Of Beta-amyloid Clearance Positive Regulation Of Neurofibrillary Tangle Assembly Lateral Motor Column Neuron Migration Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Spinal Cord Motor Neuron Migration Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Tau-protein Kinase Activity N-methyl-D-aspartate Receptor Clustering Cholesterol Transport Sterol Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Inclusion Body Assembly Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Beta-amyloid Formation Triglyceride-rich Lipoprotein Particle Remodeling Receptor-mediated Endocytosis CGMP-mediated Signaling Cholesterol Catabolic Process Negative Regulation Of Beta-amyloid Formation Positive Regulation Of Cell Differentiation Lipid Homeostasis Positive Regulation Of Cholesterol Storage Negative Regulation Of Amyloid Precursor Protein Catabolic Process Nitric Oxide Mediated Signal Transduction Regulation Of Beta-amyloid Formation Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Regulation Of Inclusion Body Assembly Reverse Cholesterol Transport Regulation Of Amyloid Precursor Protein Catabolic Process Triglyceride Catabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Steroid Catabolic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Acylglycerol Catabolic Process Glial Cell Differentiation Plasma Lipoprotein Particle Remodeling Regulation Of Protein Metabolic Process Positive Regulation Of Dendritic Spine Development Lipid Metabolic Process Positive Regulation Of Lipid Storage Postsynaptic Membrane Organization Regulation Of Phosphorylation Plasma Lipoprotein Particle Clearance Cyclic-nucleotide-mediated Signaling Positive Regulation Of Protein Catabolic Process Endocytosis Cellular Localization Gliogenesis
Tagcloud ?		ancestral ap2 boxes caat codes conform duplication exons flanking gt hsp40 intron introns lacks microexon minigene polyadenylation positions pseudogene rdj1 reeler reelin repeats rule splice successive symbol tandemly tata	1alpha ag basel chip display elucidated endothelial enhancement hampered hif huvecs hypoxia immunoblot karger luciferase markedly mimicked pretreated pretreatment protection protects recruitment robust sala salvianolic suppressing umbilical vein
Tagcloud (Difference) ?		ancestral ap2 boxes caat codes conform duplication exons flanking gt hsp40 intron introns lacks microexon minigene polyadenylation positions pseudogene rdj1 reeler reelin repeats rule splice successive symbol tandemly tata	1alpha ag basel chip display elucidated endothelial enhancement hampered hif huvecs hypoxia immunoblot karger luciferase markedly mimicked pretreated pretreatment protection protects recruitment robust sala salvianolic suppressing umbilical vein
Tagcloud (Intersection) ?