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LDB1 and IRAK3
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
LDB1
IRAK3
Description
LIM domain binding 1
interleukin 1 receptor associated kinase 3
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cell Leading Edge
Protein-containing Complex
RNA Polymerase II Transcription Regulator Complex
Beta-catenin-TCF Complex
Nucleus
Cytoplasm
Plasma Membrane
Molecular Function
DNA Binding
Chromatin Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Protein Binding
Enzyme Binding
LIM Domain Binding
Identical Protein Binding
Protein Homodimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-binding Transcription Factor Binding
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery
Gastrulation With Mouth Forming Second
Hair Follicle Development
Transcription By RNA Polymerase II
Cell Adhesion
Nervous System Development
Anterior/posterior Axis Specification
Epithelial Structure Maintenance
Wnt Signaling Pathway
Cerebellum Development
Cerebellar Purkinje Cell Differentiation
Cellular Component Assembly
Neuron Differentiation
Regulation Of Cell Migration
Positive Regulation Of Transcription Elongation By RNA Polymerase II
Somatic Stem Cell Population Maintenance
Regulation Of Kinase Activity
Negative Regulation Of Erythrocyte Differentiation
Positive Regulation Of Cell Adhesion
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Hemoglobin Biosynthetic Process
Regulation Of Focal Adhesion Assembly
Head Development
Positive Regulation Of Cytokine Production
Negative Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Immune System Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Signal Transduction
Toll Signaling Pathway
Response To Virus
Positive Regulation Of Macrophage Tolerance Induction
Negative Regulation Of Macrophage Cytokine Production
Cytokine-mediated Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Response To Peptidoglycan
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Toll-like Receptor Signaling Pathway
Intracellular Signal Transduction
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Protein-containing Complex Disassembly
Regulation Of Protein-containing Complex Disassembly
Response To Exogenous DsRNA
Negative Regulation Of MAPK Cascade
Regulation Of Innate Immune Response
Negative Regulation Of Innate Immune Response
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Pathways
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of expression of SLITs and ROBOs
Cardiogenesis
Expression and translocation of olfactory receptors
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Interleukin-1 signaling
Drugs
Fostamatinib
Diseases
GWAS
General cognitive ability (
29844566
)
Intelligence (MTAG) (
29326435
)
Mean reticulocyte volume (
32888494
)
Pulse pressure (
30578418
)
Response to esketamine in treatment resistant depression (
32724131
)
Smooth-surface caries (
24556642
)
White blood cell count (basophil) (
29403010
)
Interacting Genes
27 interacting genes:
ATXN1
CTDSP1
DNMT3L
DSCAM
ESR1
IRAK3
ISL1
LCOR
LHX1
LHX3
LMO1
LMO2
LMO3
LMO4
LMX1A
LMX1B
LSM7
POLR1B
PSMA1
PSMD10
RLIM
SP1
SSBP1
SSBP2
SSBP3
SSBP4
TOLLIP
17 interacting genes:
ADH1B
ATP6V0B
CD14
CDCA5
COPB1
ECM1
FOLR1
HOXB7
IRAK1
IRAK2
LDB1
MYD88
NONO
NSA2
NTRK3
TICAM2
TRAF6
Entrez ID
8861
11213
HPRD ID
09144
05123
Ensembl ID
ENSG00000198728
ENSG00000090376
Uniprot IDs
A0A6E1WJ75
Q86U70
Q9Y616
PDB IDs
2XJY
2XJZ
2YPA
6TYD
7OB5
7OB8
8HIB
8SSU
9F5B
5UKE
6RUU
6ZIW
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Nucleus
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Biosynthetic Process
Neuron Projection Guidance
Axon Guidance
Transcription Regulator Complex
Spinal Cord Motor Neuron Cell Fate Specification
DNA Binding
Cell Differentiation In Spinal Cord
Transcription Coregulator Binding
Spinal Cord Association Neuron Differentiation
Neuron Differentiation
Positive Regulation Of Anterior Head Development
Central Nervous System Neuron Differentiation
Motor Neuron Axon Guidance
Neuron Projection Development
BHLH Transcription Factor Binding
Neuron Fate Specification
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Single-stranded DNA Binding
Nuclear Estrogen Receptor Binding
Metal Ion Binding
Mesendoderm Development
Negative Regulation Of RNA Metabolic Process
Regionalization
Sequence-specific DNA Binding
Negative Regulation Of Macromolecule Metabolic Process
Vagina Development
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Cell Surface Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Cell Surface Pattern Recognition Receptor Signaling Pathway
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Activation Of Innate Immune Response
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Endosome Membrane
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Innate Immune Response
Interleukin-1-mediated Signaling Pathway
Innate Immune Response-activating Signaling Pathway
Positive Regulation Of Type I Interferon Production
Toll Signaling Pathway
Interleukin-33-mediated Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Activation Of Immune Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Innate Immune Response
Regulation Of Type I Interferon Production
Positive Regulation Of Defense Response
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Canonical NF-kappaB Signal Transduction
Cellular Response To Lipopolysaccharide
Cellular Response To Oxygen-containing Compound
Immune Response-activating Signaling Pathway
Cellular Response To Molecule Of Bacterial Origin
Signaling Adaptor Activity
Response To Interleukin-1
Regulation Of Immune Response
Positive Regulation Of Immune Response
Immune Response-regulating Signaling Pathway
Endolysosomal Toll-like Receptor Signaling Pathway
Cellular Response To Lipid
Non-canonical NF-kappaB Signal Transduction
Regulation Of Toll-like Receptor 4 Signaling Pathway
Regulation Of Immune System Process
Regulation Of Defense Response
Response To Lipopolysaccharide
Response To Molecule Of Bacterial Origin
Defense Response
Innate Immune Response
Regulation Of Cytokine-mediated Signaling Pathway
Canonical NF-kappaB Signal Transduction
Positive Regulation Of Immune System Process
Response To Stress
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Defense Response To Symbiont
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