LDB1 and LMX1A

Number of citations of the paper that reports this interaction (PMID 9315627)
47

Data Source:
HPRD (in vitro, in vivo)

		LDB1	LMX1A
Gene Name		LIM domain binding 1	LIM homeobox transcription factor 1, alpha
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex Protein Complex	Nucleus
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Enhancer Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Enzyme Binding LIM Domain Binding Protein Homodimerization Activity Protein Self-association	Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Gastrulation With Mouth Forming Second Hair Follicle Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Anterior/posterior Axis Specification Epithelial Structure Maintenance Wnt Signaling Pathway Cerebellar Purkinje Cell Differentiation Cellular Component Assembly Neuron Differentiation Regulation Of DNA-templated Transcription, Elongation Somatic Stem Cell Maintenance Histone H3-K4 Acetylation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hemoglobin Biosynthetic Process	Regulation Of Cell Growth Transcription, DNA-templated Regulation Of Transcription, DNA-templated Axon Guidance Dentate Gyrus Development Cerebellum Development Central Nervous System Neuron Differentiation Midbrain Development Negative Regulation Of Neuron Differentiation Dopaminergic Neuron Differentiation
Pathways
Drugs
Diseases
GWAS			Response to acetaminophen (hepatotoxicity) ( 21177773)
Protein-Protein Interactions		26 interactors: ATXN1 CTDSP1 ESR1 IRAK3 ISL1 LHX2 LHX3 LHX6 LHX8 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP	5 interactors: BMPR2 ISL1 LDB1 LHX3 TCF3
Entrez ID		8861	4009
HPRD ID		09144	02623
Ensembl ID		ENSG00000198728	ENSG00000162761
Uniprot IDs		Q86U70	Q8TE12
PDB IDs		2XJY 2XJZ 2YPA
Enriched GO Terms of Interacting Partners?		Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Central Nervous System Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Central Nervous System Development Cellular Metabolic Process Brain Development Head Development Developmental Process Organ Development Anatomical Structure Development Forebrain Development Tube Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Specification Process Cell Differentiation Negative Regulation Of Signal Transduction Multicellular Organismal Development Neuron Differentiation Anatomical Structure Morphogenesis System Development Spinal Cord Motor Neuron Differentiation Generation Of Neurons Negative Regulation Of Signaling Transcription From RNA Polymerase II Promoter Neurogenesis	Pattern Specification Process Brain Development Head Development Transcription From RNA Polymerase II Promoter Central Nervous System Development Generation Of Neurons Neurogenesis Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Spinal Cord Motor Neuron Cell Fate Specification Central Nervous System Neuron Differentiation Nervous System Development Transcription, DNA-templated RNA Biosynthetic Process Stem Cell Development Anterior/posterior Pattern Specification Anatomical Structure Morphogenesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Specification Cell Fate Commitment Stem Cell Differentiation Embryo Development Histone H3 Acetylation Organ Development Spinal Cord Motor Neuron Differentiation Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Negative Regulation Of Biosynthetic Process Pituitary Gland Development Ventral Spinal Cord Development Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Cell Differentiation In Spinal Cord Positive Regulation Of Macromolecule Biosynthetic Process Somatic Stem Cell Maintenance Anterior/posterior Axis Specification Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Neuron Fate Commitment Regulation Of Neuron Differentiation Tissue Development Diencephalon Development Mesoderm Morphogenesis Cell Fate Specification Response To External Stimulus
Tagcloud ?		assemble bhlh compatible consensus e12 erythroid erythroleukemia erythropoiesis exist forced g1er hemopoietic immature lbd1 lim lmo2 maintain maturation mediate multiprotein normally oncoprotein others precursors presumed primarily proerythroblast scl whose	ablated abundant belong belongs brdu crypt endoderm endodermal gut homeobox intestine isl1 isl2 islet1 ldb ldb1 ldb2 lhx lhx1 lim lineages lmx1b mesodermal obligatory patterning prominently quiescent terminally tracing
Tagcloud (Difference) ?		assemble bhlh compatible consensus e12 erythroid erythroleukemia erythropoiesis exist forced g1er hemopoietic immature lbd1 lmo2 maintain maturation mediate multiprotein normally oncoprotein others precursors presumed primarily proerythroblast scl whose	ablated abundant belong belongs brdu crypt endoderm endodermal gut homeobox intestine isl1 isl2 islet1 ldb ldb2 lhx lhx1 lineages lmx1b mesodermal obligatory patterning prominently quiescent terminally tracing
Tagcloud (Intersection) ?		ldb1 lim