LDB1 and LMX1A

Number of citations of the paper that reports this interaction (PubMedID 9315627)
57

Data Source:
HPRD (in vitro, in vivo)

		LDB1	LMX1A
Description		LIM domain binding 1	LIM homeobox transcription factor 1 alpha
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cell Leading Edge Protein-containing Complex RNA Polymerase II Transcription Regulator Complex Beta-catenin-TCF Complex	Chromatin Nucleus
	Molecular Function	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Enzyme Binding LIM Domain Binding Identical Protein Binding Protein Homodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Gastrulation With Mouth Forming Second Hair Follicle Development Transcription By RNA Polymerase II Cell Adhesion Nervous System Development Anterior/posterior Axis Specification Epithelial Structure Maintenance Wnt Signaling Pathway Cerebellum Development Cerebellar Purkinje Cell Differentiation Cellular Component Assembly Neuron Differentiation Regulation Of Cell Migration Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Regulation Of Kinase Activity Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Regulation Of Focal Adhesion Assembly Head Development	Regulation Of Cell Growth Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Axon Guidance Central Nervous System Development Memory Locomotory Behavior Regulation Of Gene Expression Dentate Gyrus Development Cerebellum Development Hippocampus Development Central Nervous System Neuron Differentiation Neuron Differentiation Midbrain Development Olfactory Behavior Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Synapse Organization Dopaminergic Neuron Differentiation Midbrain Dopaminergic Neuron Differentiation
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of expression of SLITs and ROBOs Cardiogenesis Expression and translocation of olfactory receptors
Drugs
Diseases
GWAS		General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Pulse pressure ( 30578418)	Age-related hearing impairment ( 34108613) Alcohol consumption (drinks per week) ( 30679032) Diffusing capacity of the lung for carbon monoxide traits ( 30049742) Hip circumference adjusted for BMI ( 34021172) Macular thickness ( 30535121) Pursuit maintenance gain ( 29064472) Response to acetaminophen (hepatotoxicity) ( 21177773) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Vestibular neuritis ( 30079052)
Interacting Genes		27 interacting genes: ATXN1 CTDSP1 DNMT3L DSCAM ESR1 IRAK3 ISL1 LCOR LHX1 LHX3 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP	5 interacting genes: BMPR2 ISL1 LDB1 LHX3 TCF3
Entrez ID		8861	4009
HPRD ID		09144	02623
Ensembl ID		ENSG00000198728	ENSG00000162761
Uniprot IDs		A0A6E1WJ75 Q86U70	Q8TE12
PDB IDs		2XJY 2XJZ 2YPA 6TYD 7OB5 7OB8 8HIB 8SSU 9F5B	8IK5 8IKE 8ILW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Neuron Projection Guidance Axon Guidance Transcription Regulator Complex Spinal Cord Motor Neuron Cell Fate Specification DNA Binding Cell Differentiation In Spinal Cord Transcription Coregulator Binding Spinal Cord Association Neuron Differentiation Neuron Differentiation Positive Regulation Of Anterior Head Development Central Nervous System Neuron Differentiation Motor Neuron Axon Guidance Neuron Projection Development BHLH Transcription Factor Binding Neuron Fate Specification RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Single-stranded DNA Binding Nuclear Estrogen Receptor Binding Metal Ion Binding Mesendoderm Development Negative Regulation Of RNA Metabolic Process Regionalization Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Vagina Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process	RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Complex Pattern Specification Process LIM Domain Binding Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of Transcription By RNA Polymerase II Central Nervous System Neuron Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Atrial Septum Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis Positive Regulation Of RNA Metabolic Process Outflow Tract Septum Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process BHLH Transcription Factor Binding Neuron Fate Specification Pituitary Gland Development Transcription Cis-regulatory Region Binding Regionalization Cell Differentiation Cell Differentiation In Spinal Cord Regulation Of Transcription By RNA Polymerase II System Development Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Biosynthetic Process Neuron Differentiation Outflow Tract Morphogenesis Cellular Developmental Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cardiac Septum Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cell Fate Specification Cis-regulatory Region Sequence-specific DNA Binding Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Lung Development Stem Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis RNA Polymerase II Transcription Regulator Complex Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Activin Receptor Activity, Type II
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