LDB1 and PSMD10

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		LDB1	PSMD10
Description		LIM domain binding 1	proteasome 26S subunit, non-ATPase 10
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cell Leading Edge Protein-containing Complex RNA Polymerase II Transcription Regulator Complex Beta-catenin-TCF Complex	Proteasome Complex Nucleus Cytoplasm Cytosol Cytoskeleton Cilium Proteasome Regulatory Particle, Base Subcomplex Microtubule Cytoskeleton
	Molecular Function	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Enzyme Binding LIM Domain Binding Identical Protein Binding Protein Homodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Gastrulation With Mouth Forming Second Hair Follicle Development Transcription By RNA Polymerase II Cell Adhesion Nervous System Development Anterior/posterior Axis Specification Epithelial Structure Maintenance Wnt Signaling Pathway Cerebellum Development Cerebellar Purkinje Cell Differentiation Cellular Component Assembly Neuron Differentiation Regulation Of Cell Migration Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Regulation Of Kinase Activity Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Regulation Of Focal Adhesion Assembly Head Development	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Cell Growth Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Proteasome Regulatory Particle Assembly Negative Regulation Of Release Of Cytochrome C From Mitochondria
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of expression of SLITs and ROBOs Cardiogenesis Expression and translocation of olfactory receptors	Proteasome assembly Proteasome assembly
Drugs
Diseases
GWAS		General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Pulse pressure ( 30578418)
Interacting Genes		27 interacting genes: ATXN1 CTDSP1 DNMT3L DSCAM ESR1 IRAK3 ISL1 LCOR LHX1 LHX3 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP	17 interacting genes: AGTR1 CCND2 CDK4 CEBPA CLIC1 GRSF1 HSPA4 LDB1 MAGEA4 MDM2 NCK2 NFKB1 PSAT1 PSMC4 RB1 RELA UBC
Entrez ID		8861	5716
HPRD ID		09144	04594
Ensembl ID		ENSG00000198728	ENSG00000101843
Uniprot IDs		A0A6E1WJ75 Q86U70	O75832
PDB IDs		2XJY 2XJZ 2YPA 6TYD 7OB5 7OB8 8HIB 8SSU 9F5B	1QYM 1TR4 1UOH 4NIK 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 7VO6 7VXV 7VXW 7VY4 7VY7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Neuron Projection Guidance Axon Guidance Transcription Regulator Complex Spinal Cord Motor Neuron Cell Fate Specification DNA Binding Cell Differentiation In Spinal Cord Transcription Coregulator Binding Spinal Cord Association Neuron Differentiation Neuron Differentiation Positive Regulation Of Anterior Head Development Central Nervous System Neuron Differentiation Motor Neuron Axon Guidance Neuron Projection Development BHLH Transcription Factor Binding Neuron Fate Specification RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Single-stranded DNA Binding Nuclear Estrogen Receptor Binding Metal Ion Binding Mesendoderm Development Negative Regulation Of RNA Metabolic Process Regionalization Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Vagina Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process	Transcription Regulator Complex NF-kappaB P50/p65 Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitotic Cell Cycle Phase Transition Cyclin D2-CDK4 Complex Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Rb-E2F Complex Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Cellular Response To Peptide Hormone Stimulus Cellular Response To Nicotine Regulation Of Inflammatory Response Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Cell Differentiation Response To Vitamin Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA-templated Transcription Initiation Regulation Of Cell Population Proliferation Actinin Binding Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Process Cellular Response To Angiotensin Cellular Response To Interleukin-6 Negative Regulation Of Apoptotic Process Cellular Response To Tumor Necrosis Factor Negative Regulation Of Programmed Cell Death Positive Regulation Of Developmental Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cell Population Proliferation Response To Interleukin-6 Positive Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Transcription By RNA Polymerase II Response To Peptide Hormone Response To Ether Response To Tumor Necrosis Factor Regulation Of Apoptotic Process Nucleoplasm Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Phase Transition Histone Deacetylase Binding
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