HDAC3 and LCOR

Number of citations of the paper that reports this interaction (PubMedID 12535528)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		HDAC3	LCOR
Description		histone deacetylase 3	ligand dependent nuclear receptor corepressor
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Transcription Repressor Complex Mitotic Spindle	Nucleus Nucleoplasm
	Molecular Function	Transcription Corepressor Binding DNA Binding Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Hydrolase Activity Deacetylase Activity Enzyme Binding Cyclin Binding Chromatin DNA Binding Protein Lysine Deacetylase Activity Histone Deacetylase Binding GTPase Binding NF-kappaB Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Decrotonylase Activity Histone Decrotonylase Activity Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Ubiquitin-specific Protease Binding	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation In Utero Embryonic Development Positive Regulation Of Protein Phosphorylation Chromatin Organization Transcription By RNA Polymerase II Protein Deacetylation Regulation Of Mitotic Cell Cycle Epidermis Development Response To Xenobiotic Stimulus Gene Expression Negative Regulation Of Myotube Differentiation Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Response To Nutrient Levels Positive Regulation Of TOR Signaling Negative Regulation Of Interleukin-1 Production Negative Regulation Of Tumor Necrosis Factor Production Circadian Regulation Of Gene Expression Protein Modification Process Regulation Of Multicellular Organism Growth Epigenetic Regulation Of Gene Expression Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Protein Export From Nucleus Rhythmic Process Spindle Assembly Random Inactivation Of X Chromosome Neural Precursor Cell Proliferation Establishment Of Skin Barrier Cellular Response To Mechanical Stimulus Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Fluid Shear Stress Response To Dexamethasone Negative Regulation Of Ferroptosis Positive Regulation Of Cold-induced Thermogenesis DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Ferroptosis Cornified Envelope Assembly Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus
Pathways		p75NTR negatively regulates cell cycle via SC1 PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Association of TriC/CCT with target proteins during biosynthesis Regulation of lipid metabolism by PPARalpha Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events STAT3 nuclear events downstream of ALK signaling Cytoprotection by HMOX1 Heme signaling Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs		Valproic acid Decitabine Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Panobinostat Phenylbutyric acid Mocetinostat Entinostat Abexinostat Givinostat Pyroxamide
Diseases
GWAS		Refractive error ( 32231278)	Peak height velocity ( 34047840) Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)
Interacting Genes		103 interacting genes: ANKRD11 ANKRD12 AR ARID4A ATF3 BCL3 BCOR BRINP1 BRIP1 BRMS1 CBFA2T3 CCN5 CCND1 CCT5 CEBPD CORO2A CREB3 CREBBP CSNK2A1 CTBP1 CUL4B DAXX DHX30 EED ELL EP300 ESR1 EWSR1 GATA1 GATA2 GATA3 GCM1 GPS2 GTF2I GTF2IRD1 H2AC1 H2BC1 H3C1 H4C1 HDAC1 HDAC10 HDAC4 HDAC5 HDAC7 HDAC9 HIF1A HIF1AN HNF4A HR HSPA4 HSPA8 IL16 JUN KLF6 LCOR MAPK11 MAPK14 MBD1 NACC1 NCOR1 NCOR2 NFKBIA NR0B2 NR2C1 NR2E3 NRIP1 PARP1 PHB2 PIAS2 PML PPARD PPARG PPP4C PPP4R1 PRKDC RARA RB1 RBBP4 RELA RUNX1T1 RUNX2 RXRA SMYD1 SRC SRY STAT3 SUV39H1 SYK TAB2 TBL1X TBL1XR1 THAP11 THAP7 THRA THRB TMPO TNFRSF14 TP53 TXNIP VHL XPO1 YY1 ZBTB16	144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE
Entrez ID		8841	84458
HPRD ID		08950	07609
Ensembl ID		ENSG00000171720	ENSG00000196233
Uniprot IDs		O15379	Q96JN0
PDB IDs		4A69	2COB 6V3X 6V3Y
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Histone Deacetylase Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Positive Regulation Of RNA Metabolic Process DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Cell Differentiation Transcription Repressor Complex Transcription Regulator Complex DNA-binding Transcription Factor Binding Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of MiRNA Transcription Chromatin Organization Transcription Coactivator Binding Regulation Of MiRNA Metabolic Process Regulation Of Developmental Process Histone Deacetylase Complex DNA-binding Transcription Factor Activity	Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding
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