CCN4 and OTX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCN4	OTX1
Description		cellular communication network factor 4	orthodenticle homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Extracellular Matrix	Chromatin Nucleus
	Molecular Function	Integrin Binding Protein Binding Heparin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Osteoblast Differentiation Regulation Of Cytokine Production Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Smooth Muscle Cell Migration Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Osteoclast Differentiation Negative Regulation Of Chondrocyte Differentiation Glucose Homeostasis Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Regulation Of Multicellular Organismal Process Bone Development Positive Regulation Of Wound Healing	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Metencephalon Development Forebrain Development Midbrain Development Inner Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Diencephalon Morphogenesis
Pathways
Drugs
Diseases
GWAS		Asthma ( 34103634)	Fruit consumption ( 32066663) Neurociticism ( 29500382) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		4 interacting genes: BGN DCN HOXA1 OTX1	148 interacting genes: ADAM12 ADAMTSL4 ALPP ANKRD10 ARHGEF17 ARID5A ATG9B C10orf55 CCN4 CERCAM CFAP68 CH25H CHIC2 CHRD CHRDL2 COL8A1 COMP CTAG2 CYSRT1 DPY30 EFEMP2 ETFDH FAM168B FAM72B FBLN2 FBLN5 FHL5 GEMIN8P4 GPRASP3 GPRIN2 GRN HIVEP1 HOXA1 INTS11 KCNK16 KLHL26 KPRP KRT31 KRT35 KRT37 KRT81 KRT85 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-1 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1B LCE1C LCE1F LCE2A LCE2B LCE2C LCE2D LCE4A LGALS13 M1AP MDFI MGAT5B MIIP MTNR1B NBPF19 NDUFAF6 NECTIN3 NHLRC4 NOTCH2NLA OXER1 PCSK5 PLA2G10 PLEKHG4 PLSCR2 POU2AF1 PRICKLE4 PRR13 PRR22 RBPMS RGS17 RGS19 RGS20 RNF144B RTN4R SLC15A2 SMARCC1 SPMIP9 SPRY1 SPRY2 SPRY4 SPRYD7 TLE4 TNS2 TRIM42 TRIP6 TSPAN4 UBAP2 USP54 VWC2 VWC2L WWOX YPEL3 ZBTB42 ZNF330 ZNF34
Entrez ID		8840	5013
HPRD ID		16019	08964
Ensembl ID		ENSG00000104415	ENSG00000115507
Uniprot IDs		O95388	P32242
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Structural Constituent Conferring Compression Resistance Glycosaminoglycan Binding Extracellular Matrix Binding Lysosomal Lumen Semicircular Canal Formation Diencephalon Morphogenesis Golgi Lumen Abducens Nerve Formation Optokinetic Behavior Metencephalon Development Articular Cartilage Development Axonemal Central Apparatus Assembly Positive Regulation Of Mitochondrial Depolarization Outer Ear Morphogenesis Embryonic Neurocranium Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Radial Spoke Positive Regulation Of Membrane Depolarization Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Sperm Head-tail Coupling Apparatus Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Extracellular Matrix Positive Regulation Of Mitochondrial Fission Anatomical Structure Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Morphogenesis Regulation Of Mitochondrial Depolarization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cochlea Morphogenesis Regulation Of Mitochondrial Fission	Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Protein Binding Structural Molecule Activity Cytosol Structural Constituent Of Skin Epidermis Negative Regulation Of Cellular Response To Growth Factor Stimulus
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