CCN4 and DCN

Number of citations of the paper that reports this interaction (PubMedID 11598131)
0

Data Source:
HPRD (in vitro)

		CCN4	DCN
Description		cellular communication network factor 4	decorin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Extracellular Matrix	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen
	Molecular Function	Integrin Binding Protein Binding Heparin Binding	RNA Binding Protein Binding Glycosaminoglycan Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Binding
	Biological Process	Osteoblast Differentiation Regulation Of Cytokine Production Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Smooth Muscle Cell Migration Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Osteoclast Differentiation Negative Regulation Of Chondrocyte Differentiation Glucose Homeostasis Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Regulation Of Multicellular Organismal Process Bone Development Positive Regulation Of Wound Healing	Animal Organ Morphogenesis Positive Regulation Of Autophagy Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Macroautophagy Negative Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Mitochondrial Fission Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Pathways			Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Diseases			Congenital stromal corneal dystrophy (CSCD); Congenital hereditary stromal dystrophy; Witschel dystrophy
GWAS		Asthma ( 34103634)	Blood protein levels ( 30072576) Central corneal thickness ( 29760442 32528159) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998) Refractive error ( 32231278) Sudden cardiac arrest ( 21658281)
Interacting Genes		4 interacting genes: BGN DCN HOXA1 OTX1	32 interacting genes: ADARB1 AHSG BRCA1 C1QA CCN4 COL14A1 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL6A1 DPT EGFR ELN FBN1 FLNA FN1 MET MMP2 MMP3 MMP7 PLA2G2A SF1 SFTPD TGFB1 TGFB2 THBS1 TNF
Entrez ID		8840	1634
HPRD ID		16019	00501
Ensembl ID		ENSG00000104415	ENSG00000011465
Uniprot IDs		O95388	P07585 Q6FH10
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Structural Constituent Conferring Compression Resistance Glycosaminoglycan Binding Extracellular Matrix Binding Lysosomal Lumen Semicircular Canal Formation Diencephalon Morphogenesis Golgi Lumen Abducens Nerve Formation Optokinetic Behavior Metencephalon Development Articular Cartilage Development Axonemal Central Apparatus Assembly Positive Regulation Of Mitochondrial Depolarization Outer Ear Morphogenesis Embryonic Neurocranium Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Radial Spoke Positive Regulation Of Membrane Depolarization Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Sperm Head-tail Coupling Apparatus Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Extracellular Matrix Positive Regulation Of Mitochondrial Fission Anatomical Structure Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Morphogenesis Regulation Of Mitochondrial Depolarization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cochlea Morphogenesis Regulation Of Mitochondrial Fission	Extracellular Matrix Extracellular Region Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Collagen Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Endoplasmic Reticulum Lumen Cellular Response To Amino Acid Stimulus Basement Membrane Collagen Type IV Trimer Response To Amino Acid Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Platelet-derived Growth Factor Binding Extracellular Space Collagen Fibril Organization Collagen Metabolic Process Collagen-activated Signaling Pathway Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Population Proliferation Enzyme-linked Receptor Protein Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Cell Motility Animal Organ Morphogenesis Regulation Of Locomotion Regulation Of Smooth Muscle Cell Proliferation Developmental Process Negative Regulation Of Multicellular Organismal Process Animal Organ Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Platelet Alpha Granule Lumen Extracellular Matrix Assembly Integrin Binding Face Morphogenesis Tissue Development Negative Regulation Of Cell Population Proliferation Fibrillar Collagen Trimer Positive Regulation Of Smooth Muscle Cell Proliferation Salivary Gland Morphogenesis Response To Xenobiotic Stimulus Cell Morphogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Adhesion Response To Mechanical Stimulus Protease Binding
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