MYOT and FLNC

Number of citations of the paper that reports this interaction (PubMedID 11038172)
64

Data Source:
HPRD (two hybrid, in vivo)

		MYOT	FLNC
Description		myotilin	filamin C
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Z Disc Axon Sarcolemma Neuronal Cell Body	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Sarcoplasm Z Disc Sarcolemma Costamere Intercellular Bridge
	Molecular Function	Actin Binding Protein Binding Axon Guidance Receptor Activity Structural Constituent Of Muscle Alpha-actinin Binding	Actin Binding Protein Binding Cytoskeletal Protein Binding Ankyrin Binding Identical Protein Binding Actin Filament Binding
	Biological Process	Muscle Contraction Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Synapse Organization	Actin Cytoskeleton Organization Sarcomere Organization Muscle Cell Development
Pathways			Cell-extracellular matrix interactions
Drugs
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Limb-girdle muscular dystrophy (LGMD) Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)	Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS		Atrial fibrillation ( 30061737) Heart rate ( 23583979) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)	Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Interacting Genes		17 interacting genes: ACTN1 ACTN2 ACTN3 APP AXIN1 DOCK9 FLNA FLNC GPRASP2 LRP12 NME7 PDLIM3 PFDN5 ST7 TFG TRIM55 TRIM63	35 interacting genes: ADRA1A ADRA1B ADRA1D CAPN3 CDC42 ENO1 FURIN HIPK3 HSPB2 INPPL1 KCND2 KY MAP2K4 MTDH MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA REPS1 RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2
Entrez ID		9499	2318
HPRD ID		04981	00018
Ensembl ID		ENSG00000120729	ENSG00000128591
Uniprot IDs		A0A0C4DFM5 B4DT68 Q9UBF9	Q14315 Q59H94
PDB IDs		2KDG 2KKQ	1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O 4MGX 7OUU 7OUV 7P0E 8PA0
Enriched GO Terms of Interacting Partners?		Z Disc Integrin Binding Cytoskeletal Protein Binding Pseudopodium Actin Cytoskeleton Organization Actin Filament Binding Actin Binding Actin Filament Actin Filament-based Process Muscle Cell Development Focal Adhesion Assembly Actin Cytoskeleton Cell-substrate Junction Assembly Transmembrane Transporter Binding Cell-substrate Junction Organization Skeletal Muscle Atrophy Structural Constituent Of Muscle Cell Development Cortical Actin Cytoskeleton Cellular Component Assembly Regulation Of Glycolytic Process Skeletal Muscle Adaptation Striated Muscle Atrophy Sarcomere Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Platelet Alpha Granule Lumen Muscle Atrophy Regulation Of Carbohydrate Catabolic Process Focal Adhesion G Protein-coupled Receptor Binding Regulation Of ATP Metabolic Process Titin Binding Regulation Of Purine Nucleotide Metabolic Process Supramolecular Fiber Organization Identical Protein Binding Regulation Of Amyloid Fibril Formation Cytosol Negative Regulation Of Glycolytic Process Protein Serine/threonine Kinase Binding Organelle Organization Negative Regulation Of ATP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Potassium Ion Transport Cytoplasm Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Wnt Signaling Pathway Sarcomere Organization Dendritic Shaft	Z Disc Alpha1-adrenergic Receptor Activity Actin Binding Neuron-glial Cell Signaling Actin Filament-based Process FATZ Binding Heart Contraction Telethonin Binding Actin Cytoskeleton Organization Heart Process Adrenergic Receptor Activity Sarcomere Organization Cytoplasm Circulatory System Process Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Alpha-actinin Binding Striated Muscle Tissue Development Muscle Structure Development Adrenergic Receptor Signaling Pathway Skeletal Muscle Fiber Adaptation Regulation Of System Process Muscle Tissue Development Anchoring Junction M Band Cytoskeleton Organization Dystroglycan Complex Supramolecular Fiber Organization Muscle Contraction Sarcoglycan Complex Actomyosin Structure Organization Regulation Of Intracellular Signal Transduction Structural Constituent Of Muscle System Process Regulation Of Signal Transduction Regulation Of Skeletal Muscle Tissue Regeneration Muscle Organ Development Regulation Of Supramolecular Fiber Organization Regulation Of Muscle System Process Muscle System Process Regulation Of Actin Filament Organization Regulation Of Protein Processing Actin Cytoskeleton Regulation Of Protein Maturation Cardiac Muscle Tissue Development Titin Binding Regulation Of Vasoconstriction Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cytoskeleton Regulation Of Cell Communication
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?