MYOT and NME7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MYOT	NME7
Description		myotilin	NME/NM23 family member 7
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Z Disc Axon Sarcolemma Neuronal Cell Body	Gamma-tubulin Ring Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Axonemal Microtubule Plasma Membrane Cilium Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath
	Molecular Function	Actin Binding Protein Binding Axon Guidance Receptor Activity Structural Constituent Of Muscle Alpha-actinin Binding	Nucleoside Diphosphate Kinase Activity Protein Kinase Activity Protein Binding ATP Binding 3'-5'-DNA Exonuclease Activity Kinase Activity Transferase Activity Hydrolase Activity
	Biological Process	Muscle Contraction Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Synapse Organization	Epithelial Cilium Movement Involved In Extracellular Fluid Movement GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Catabolic Process Determination Of Left/right Symmetry Brain Development Regulation Of Microtubule Nucleation Flagellated Sperm Motility Intraciliary Transport Receptor Clustering Cilium Assembly Left/right Pattern Formation Cellular Response To Leukemia Inhibitory Factor
Pathways			Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes
Drugs
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Limb-girdle muscular dystrophy (LGMD) Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS		Atrial fibrillation ( 30061737) Heart rate ( 23583979) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)	Coronary artery disease ( 29212778) D-dimer levels ( 21502573) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left-handedness ( 32989287) Myocardial infarction ( 33532862) Pulse pressure ( 27841878 30578418) QT interval ( 30679814) Systolic blood pressure ( 27841878 30578418) Venous thromboembolism ( 21980494 22672568 30659681 33592630)
Interacting Genes		17 interacting genes: ACTN1 ACTN2 ACTN3 APP AXIN1 DOCK9 FLNA FLNC GPRASP2 LRP12 NME7 PDLIM3 PFDN5 ST7 TFG TRIM55 TRIM63	74 interacting genes: AMOTL2 ARHGAP9 BTBD6 CARD10 CBY2 CCDC136 CCDC33 CCDC88B CCHCR1 CDC42EP2 CEP72 DDIT4L DDX1 DISC1 DNAI7 EFHC2 FKBP6 FLOT1 FOSL1 FOSL2 GATAD2B GLIS2 GOLGA2 GSC2 HAUS8 IKZF1 IKZF3 INCA1 ISY1-RAB43 KRT18 KRT75 LNX1 MAP4K4 MED11 MED30 MEI4 MEOX2 MYOT NAB2 NEFL NFKBIL1 NIF3L1 NME4 NT5C2 OFD1 PAX4 PIAS2 PICK1 POU6F2 PROSER3 PSMA1 REL RUBCN SHTN1 SNAPIN SNX32 SYCE1 TCF4 TCHP TEKT1 TEPSIN THAP10 TNIP1 TNNI2 TRIM27 TRIM48 TUFT1 YWHAQ ZBTB48 ZNF23 ZNF263 ZNF343 ZNF526 ZNF620
Entrez ID		9499	29922
HPRD ID		04981	11394
Ensembl ID		ENSG00000120729	ENSG00000143156
Uniprot IDs		A0A0C4DFM5 B4DT68 Q9UBF9	Q9Y5B8
PDB IDs		2KDG 2KKQ	7UNG 8J07
Enriched GO Terms of Interacting Partners?		Z Disc Integrin Binding Cytoskeletal Protein Binding Pseudopodium Actin Cytoskeleton Organization Actin Filament Binding Actin Binding Actin Filament Actin Filament-based Process Muscle Cell Development Focal Adhesion Assembly Actin Cytoskeleton Cell-substrate Junction Assembly Transmembrane Transporter Binding Cell-substrate Junction Organization Skeletal Muscle Atrophy Structural Constituent Of Muscle Cell Development Cortical Actin Cytoskeleton Cellular Component Assembly Regulation Of Glycolytic Process Skeletal Muscle Adaptation Striated Muscle Atrophy Sarcomere Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Platelet Alpha Granule Lumen Muscle Atrophy Regulation Of Carbohydrate Catabolic Process Focal Adhesion G Protein-coupled Receptor Binding Regulation Of ATP Metabolic Process Titin Binding Regulation Of Purine Nucleotide Metabolic Process Supramolecular Fiber Organization Identical Protein Binding Regulation Of Amyloid Fibril Formation Cytosol Negative Regulation Of Glycolytic Process Protein Serine/threonine Kinase Binding Organelle Organization Negative Regulation Of ATP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Potassium Ion Transport Cytoplasm Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Wnt Signaling Pathway Sarcomere Organization Dendritic Shaft	Protein Binding Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Transcription Coregulator Activity Regulation Of RNA Metabolic Process Phosphatidylinositol 3-kinase Inhibitor Activity
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