TSC1 and HNRNPM

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		TSC1	HNRNPM
Description		TSC complex subunit 1	heterogeneous nuclear ribonucleoprotein M
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Lysosomal Membrane Lipid Droplet Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Protein-containing Complex TSC1-TSC2 Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm Protein Folding Chaperone Complex	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Membrane Nuclear Matrix Paraspeckles Synapse Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding Hsp70 Protein Binding ATPase Inhibitor Activity Protein Folding Chaperone Protein-folding Chaperone Binding Hsp90 Protein Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding
	Biological Process	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion Adaptive Immune Response Protein Folding Potassium Ion Transport Cell-matrix Adhesion Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Associative Learning Adult Locomotory Behavior Cellular Response To Starvation Negative Regulation Of Macroautophagy Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Negative Regulation Of ATP-dependent Activity Response To Insulin Cellular Response To Decreased Oxygen Levels TORC1 Signaling Myelination Memory T Cell Differentiation Negative Regulation Of Cell Size D-glucose Import Synapse Organization Protein Stabilization Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Activation Of GTPase Activity Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		Macroautophagy Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes TBC/RABGAPs	FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases		Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Migraine without aura ( 23793025) Psoriasis ( 19169254)	Appendicular lean mass ( 33097823) Coronary artery disease ( 29212778)
Interacting Genes		169 interacting genes: ABI1 ACTN1 ACTN2 AKT1 ANKIB1 ANKRD24 ANKRD35 APPL2 AQP1 ARAF ARID5A ATN1 ATXN1 AURKA AXIN1 BAG3 BCL11A BECN1 BEND5 C1orf94 CALCOCO2 CASC3 CCDC120 CCDC88B CCL28 CCNB1 CCND2 CCNE1 CDK1 CDK4 CDK6 CDKN2A CDKN2B CDR2 CHCHD2 CNIH1 CNTRL CNTROB COG6 CSTF2 CTNNB1 DACH2 DCTN2 DMRT3 DOK5 EIF3A ENKD1 EZR FAM110A FAM222B FBF1 FGFR4 FOXH1 FRS3 GCC1 GEMIN8 GFAP GLIS2 GOLGA2 GPANK1 GPATCH1 HECW1 HGS HNRNPM HOMER3 HOOK2 HOXC8 HR HSH2D ICA1 IGFN1 IKBKB KANSL2 KAT2A KAZN KDM1A KIF1C KIF5A KLC1 KLC4 LATS2 LENG1 LMO2 LRSAM1 LUC7L LZTS2 MAP2K5 MAPK14 MBIP MBP MSANTD3 MSN MT-ND1 MYC MYLIP MYOZ3 NECAB2 NEFL NF2 NINL NKD2 NRBF2 PATL1 PATZ1 PHLDB1 PICK1 PITX1 PLK1 PLK2 POGZ POU6F2 PPFIA2 PPP1R18 PRMT6 RALYL RASSF1 RBPMS RDX RHEB RIN1 RIN3 RUNDC3A SAMD11 SAMD7 SAXO4 SCMH1 SEC31A SELENOW SERTAD1 SH2D2A SHANK1 SHC3 SMG9 SORBS3 SOX4 SPAG5 SPAG8 SUOX TANK TBC1D7 TBX6 TCF7L2 TFAP2D TFIP11 TLE5 TNS2 TRIM3 TRIOBP TSC2 TSGA10IP TSHZ3 USP2-AS1 VENTX VEZF1 VGLL3 VIM VPS37C YPEL3 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZIC1 ZNF417 ZNF423 ZNF587 ZNF765	117 interacting genes: AKAP9 APC CDC5L CEACAM5 DUX4 ECPAS FXR1 FXR2 GMCL2 GSK3A GSK3B HGS HNRNPF HNRNPH1 JUN LENG8 LINC00624 LMO1 LMO2 LMO3 LONRF2 LYST MAGEA6 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT PLRG1 PRRC2A RBM4 RBM4B SMARCB1 STAT3 SUMO2 TCERG1 TEKT4 TNKS TRAF1 TSC1 TSGA10 U2AF1 UBC UBE2I USP7 WDR77 WEE2-AS1 YWHAG ZNF207
Entrez ID		7248	4670
HPRD ID		05594	01188
Ensembl ID		ENSG00000165699	ENSG00000099783
Uniprot IDs		A0A2R8Y5M3 A0A2R8Y5N2 A0A2R8Y5S3 A0A2R8Y6S1 A0A2R8YD74 A0A2R8YFV7 Q32NF0 Q86WV8 Q92574 X5D9D2	P52272 Q59ES8
PDB IDs		4Z6Y 5EJC 7DL2 9C9I 9CE3	2DGV 2DH9 2DO0 2OT8
Enriched GO Terms of Interacting Partners?		Cytoskeleton Protein Domain Specific Binding Regulation Of Primary Metabolic Process Cytoplasm Protein Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Localization To Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Spindle Pole Microtubule-based Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Negative Regulation Of Biosynthetic Process Protein Kinase Binding Negative Regulation Of Macromolecule Metabolic Process Identical Protein Binding Cytoskeleton Organization Organelle Organization Negative Regulation Of Metabolic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Intracellular Transport Cell Cycle G1/S Phase Transition Mitotic Cell Cycle Phase Transition Cytoskeletal Protein Binding Cytosol Regulation Of Protein Localization Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Transcription By RNA Polymerase II Microtubule Cytoskeleton Organization Involved In Mitosis MAPK Cascade Cell Cycle Phase Transition Cell Division Positive Regulation Of Early Endosome To Late Endosome Transport Centrosome	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Positive Regulation Of MRNA Catabolic Process RNA Destabilization Positive Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Cytokine Production Negative Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of MRNA Stability Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Vasculature Development Regulation Of RNA Stability Negative Regulation Of Protein Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Regulation Of MRNA Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cell Migration Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Motility Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion Regulation Of Cellular Response To Growth Factor Stimulus
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?