TSC1 and NEFL

Number of citations of the paper that reports this interaction (PMID 12226091)
9

Data Source:
HPRD (in vivo)

		TSC1	NEFL
Gene Name		tuberous sclerosis 1	neurofilament, light polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Cell Cortex Membrane Lamellipodium Growth Cone TSC1-TSC2 Complex Intracellular Membrane-bounded Organelle Protein Complex	Cytoplasm Cytosol Neurofilament Axon Growth Cone TSC1-TSC2 Complex
	Molecular Function	Protein Binding GTPase Regulator Activity GTPase Activating Protein Binding Protein N-terminus Binding Chaperone Binding	Structural Constituent Of Cytoskeleton Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Protein Binding, Bridging Identical Protein Binding Phospholipase Binding
	Biological Process	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion RRNA Export From Nucleus Regulation Of Translation Potassium Ion Transport Cell Cycle Arrest Cell-matrix Adhesion Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Translation Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Activation Of Rho GTPase Activity Response To Insulin Myelination Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Cell Size Regulation Of Protein Kinase Activity Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Synapse Organization Protein Stabilization Protein Heterooligomerization Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation	Microtubule Cytoskeleton Organization Synaptic Transmission Anterograde Axon Cargo Transport Retrograde Axon Cargo Transport Response To Toxic Substance Peripheral Nervous System Axon Regeneration Axon Transport Of Mitochondrion Regulation Of Axon Diameter Neurofilament Bundle Assembly Locomotion Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Intermediate Filament Organization Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Neuromuscular Process Controlling Balance Protein Polymerization Response To Corticosterone
Pathways		Inhibition of TSC complex formation by PKB Insulin receptor signalling cascade IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling IRS-related events mTOR signalling Inhibition of TSC complex formation by PKB IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor	Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Psoriasis ( 19169254)
Protein-Protein Interactions		23 interactors: AKT1 ATXN1 CCNB1 CDK1 EZR IKBKB KDM1A MSN NEFL NF2 NGFRAP1 PLK1 PRMT6 RDX RHEB TBC1D7 TSC2 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	29 interactors: BRD7 CCNC CDK5RAP2 CHD3 ENKD1 GRIN1 KDM1A KIFC3 KRT15 MAP2 MTMR2 MYO5A NDN NEFH NME7 PDE4DIP PIAS4 PKN1 PPP1R16B PPP1R18 PRMT6 SPTAN1 TERF1 TEX11 TSC1 TXLNB USP2 VIM YWHAG
Entrez ID		7248	4747
HPRD ID		05594	01206
Ensembl ID		ENSG00000165699
Uniprot IDs		Q32NF0 Q86WV8 Q92574	P07196
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Mitochondrion Organization Positive Regulation Of Intracellular Transport Regulation Of Apoptotic Process Membrane Organization Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Localization Neurotrophin Signaling Pathway Regulation Of Signal Transduction Cellular Localization Regulation Of Intracellular Transport Regulation Of Signaling Positive Regulation Of Transport Cellular Protein Localization Regulation Of Cellular Localization Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Protein Localization Cellular Response To Insulin Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Gene Expression Response To Growth Factor Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Cell Death Negative Regulation Of Protein Metabolic Process Peptidyl-serine Phosphorylation Protein Targeting G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Mitotic Cell Cycle Phase Transition Apoptotic Process Regulation Of Cellular Process Cell Cycle Phase Transition Response To Peptide Hormone	Nervous System Development Developmental Process Anatomical Structure Development Regulation Of Cellular Component Organization System Development Central Nervous System Development Organelle Organization Cell Differentiation Cell Projection Organization Regulation Of Cellular Protein Metabolic Process Generation Of Neurons Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Neurogenesis Regulation Of Organelle Organization Regulation Of Protein Metabolic Process Cell Cycle Cell Development Movement Of Cell Or Subcellular Component Microtubule-based Process Intermediate Filament Organization Axonogenesis Regulation Of Cellular Process Response To Stimulus G2/M Transition Of Mitotic Cell Cycle Axon Development Regulation Of Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Cycle Cellular Component Maintenance Chromatin Modification Negative Regulation Of Biosynthetic Process Neuron Development Regulation Of Transcription From RNA Polymerase II Promoter Neuron Projection Morphogenesis Myelination Axon Ensheathment Chromosome Organization Cell Cycle Process Regulation Of Gene Expression Regulation Of Microtubule-based Process Chromatin Organization Cell Morphogenesis Involved In Differentiation Intermediate Filament Cytoskeleton Organization Neuron Differentiation Intermediate Filament-based Process Protein Oligomerization Microtubule Bundle Formation Microtubule Cytoskeleton Organization Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Tagcloud ?		abnormally autosomal deprived formations glutamine hamartin immunosuppressant impairments indicators lifespan master mechanistically mtorc1 neurocognitive neuropsychological orally physiologically premature rapamycin s6 seizures starvation surrogate tsc2 tuber tuberin tuberous withdrawal	abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma klf4 lna locked maldi multiforme nanog nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Difference) ?		abnormally autosomal deprived formations glutamine hamartin immunosuppressant impairments indicators lifespan master mechanistically mtorc1 neurocognitive neuropsychological orally physiologically premature rapamycin s6 seizures starvation surrogate tsc2 tuber tuberin tuberous withdrawal	abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma klf4 lna locked maldi multiforme nanog nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Intersection) ?