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TSC1 and RDX
Number of citations of the paper that reports this interaction (PubMedID
10806479
)
0
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
TSC1
RDX
Description
TSC complex subunit 1
radixin
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lysosome
Lysosomal Membrane
Lipid Droplet
Cytosol
Actin Filament
Plasma Membrane
Cell Cortex
Postsynaptic Density
Membrane
Lamellipodium
Protein-containing Complex
TSC1-TSC2 Complex
Ciliary Basal Body
Perinuclear Region Of Cytoplasm
Protein Folding Chaperone Complex
Ruffle
Extracellular Space
Cytoplasm
Cytoskeleton
Plasma Membrane
Microvillus
Adherens Junction
Focal Adhesion
Membrane
Apical Plasma Membrane
Lamellipodium
Filopodium
T-tubule
Midbody
Cortical Actin Cytoskeleton
Cleavage Furrow
Stereocilium
Cell Projection
Apical Part Of Cell
Cell Tip
Extracellular Exosome
Cell Periphery
Stereocilium Base
Molecular Function
Protein Binding
Hsp70 Protein Binding
ATPase Inhibitor Activity
Protein Folding Chaperone
Protein-folding Chaperone Binding
Hsp90 Protein Binding
RNA Binding
Actin Binding
Protein Binding
Cytoskeletal Protein Binding
Protein Domain Specific Binding
Cadherin Binding
Cell Adhesion Molecule Binding
Protein Kinase A Binding
ATPase Binding
Biological Process
Kidney Development
Neural Tube Closure
Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
Protein Folding
Potassium Ion Transport
Cell-matrix Adhesion
Nervous System Development
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Associative Learning
Adult Locomotory Behavior
Cellular Response To Starvation
Negative Regulation Of Macroautophagy
Hippocampus Development
Cerebral Cortex Development
Cell Projection Organization
Negative Regulation Of TOR Signaling
Negative Regulation Of ATP-dependent Activity
Response To Insulin
Cellular Response To Decreased Oxygen Levels
TORC1 Signaling
Myelination
Memory T Cell Differentiation
Negative Regulation Of Cell Size
D-glucose Import
Synapse Organization
Protein Stabilization
Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Positive Regulation Of Focal Adhesion Assembly
Cardiac Muscle Cell Differentiation
Activation Of GTPase Activity
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Regulation Of Cell Shape
Positive Regulation Of Gene Expression
Protein Kinase A Signaling
Microvillus Assembly
Regulation Of Rap Protein Signal Transduction
Cellular Response To Platelet-derived Growth Factor Stimulus
Apical Protein Localization
Establishment Of Protein Localization
Positive Regulation Of Protein Catabolic Process
Barbed-end Actin Filament Capping
Actin Filament Capping
Establishment Of Endothelial Barrier
Establishment Of Protein Localization To Plasma Membrane
Protein Localization To Plasma Membrane
Cellular Response To Thyroid Hormone Stimulus
Regulation Of Postsynaptic Neurotransmitter Receptor Diffusion Trapping
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Organelle Assembly
Positive Regulation Of Protein Localization To Early Endosome
Regulation Of Adherens Junction Organization
Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways
Macroautophagy
Inhibition of TSC complex formation by PKB
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
TBC/RABGAPs
Recycling pathway of L1
Recycling pathway of L1
Sensory processing of sound by inner hair cells of the cochlea
Sensory processing of sound by outer hair cells of the cochlea
Drugs
1D-myo-inositol 1,4,5-trisphosphate
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Migraine without aura (
23793025
)
Psoriasis (
19169254
)
Cognitive function (
24684796
)
Computer vision syndrome (
33941792
)
Coronary artery disease (
32469254
)
Multiple sclerosis (
31604244
)
Interacting Genes
169 interacting genes:
ABI1
ACTN1
ACTN2
AKT1
ANKIB1
ANKRD24
ANKRD35
APPL2
AQP1
ARAF
ARID5A
ATN1
ATXN1
AURKA
AXIN1
BAG3
BCL11A
BECN1
BEND5
C1orf94
CALCOCO2
CASC3
CCDC120
CCDC88B
CCL28
CCNB1
CCND2
CCNE1
CDK1
CDK4
CDK6
CDKN2A
CDKN2B
CDR2
CHCHD2
CNIH1
CNTRL
CNTROB
COG6
CSTF2
CTNNB1
DACH2
DCTN2
DMRT3
DOK5
EIF3A
ENKD1
EZR
FAM110A
FAM222B
FBF1
FGFR4
FOXH1
FRS3
GCC1
GEMIN8
GFAP
GLIS2
GOLGA2
GPANK1
GPATCH1
HECW1
HGS
HNRNPM
HOMER3
HOOK2
HOXC8
HR
HSH2D
ICA1
IGFN1
IKBKB
KANSL2
KAT2A
KAZN
KDM1A
KIF1C
KIF5A
KLC1
KLC4
LATS2
LENG1
LMO2
LRSAM1
LUC7L
LZTS2
MAP2K5
MAPK14
MBIP
MBP
MSANTD3
MSN
MT-ND1
MYC
MYLIP
MYOZ3
NECAB2
NEFL
NF2
NINL
NKD2
NRBF2
PATL1
PATZ1
PHLDB1
PICK1
PITX1
PLK1
PLK2
POGZ
POU6F2
PPFIA2
PPP1R18
PRMT6
RALYL
RASSF1
RBPMS
RDX
RHEB
RIN1
RIN3
RUNDC3A
SAMD11
SAMD7
SAXO4
SCMH1
SEC31A
SELENOW
SERTAD1
SH2D2A
SHANK1
SHC3
SMG9
SORBS3
SOX4
SPAG5
SPAG8
SUOX
TANK
TBC1D7
TBX6
TCF7L2
TFAP2D
TFIP11
TLE5
TNS2
TRIM3
TRIOBP
TSC2
TSGA10IP
TSHZ3
USP2-AS1
VENTX
VEZF1
VGLL3
VIM
VPS37C
YPEL3
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZIC1
ZNF417
ZNF423
ZNF587
ZNF765
23 interacting genes:
ABCC2
ARHGDIA
C1QTNF9
CALM1
CPNE1
CPNE2
CPNE4
DRD3
EZR
FTCD
GNA13
ICAM2
ITGB2
L1CAM
LINC01554
NHERF1
NHERF2
PRPF38A
PSME3
RBPMS
ROCK1
TSC1
VPS11
Entrez ID
7248
5962
HPRD ID
05594
01534
Ensembl ID
ENSG00000165699
ENSG00000137710
Uniprot IDs
A0A2R8Y5M3
A0A2R8Y5N2
A0A2R8Y5S3
A0A2R8Y6S1
A0A2R8YD74
A0A2R8YFV7
Q32NF0
Q86WV8
Q92574
X5D9D2
B0YJ88
P35241
Q6PKD3
PDB IDs
4Z6Y
5EJC
7DL2
9C9I
9CE3
Enriched GO Terms of Interacting Partners
?
Cytoskeleton
Protein Domain Specific Binding
Regulation Of Primary Metabolic Process
Cytoplasm
Protein Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Protein Localization To Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Spindle Pole
Microtubule-based Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Microtubule Cytoskeleton Organization
Negative Regulation Of Biosynthetic Process
Protein Kinase Binding
Negative Regulation Of Macromolecule Metabolic Process
Identical Protein Binding
Cytoskeleton Organization
Organelle Organization
Negative Regulation Of Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Intracellular Transport
Cell Cycle G1/S Phase Transition
Mitotic Cell Cycle Phase Transition
Cytoskeletal Protein Binding
Cytosol
Regulation Of Protein Localization
Positive Regulation Of Protein Localization To Nucleus
Negative Regulation Of Transcription By RNA Polymerase II
Microtubule Cytoskeleton Organization Involved In Mitosis
MAPK Cascade
Cell Cycle Phase Transition
Cell Division
Positive Regulation Of Early Endosome To Late Endosome Transport
Centrosome
Type 2 Metabotropic Glutamate Receptor Binding
Membrane Docking
Type 3 Metabotropic Glutamate Receptor Binding
Membrane To Membrane Docking
Response To Calcium Ion
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Regulation Of Cell Shape
Leukocyte Cell-cell Adhesion
Protein Localization To Membrane
Microvillus Organization
Positive Regulation Of Early Endosome To Late Endosome Transport
Microvillus Assembly
Calcium-dependent Phospholipid Binding
Plasma Membrane
Response To Metal Ion
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Rho Protein Signal Transduction
Microvillus
Receptor Internalization
Uropod
Protein Localization To Plasma Membrane
Cellular Response To Calcium Ion
Regulation Of Intracellular Signal Transduction
Establishment Of Epithelial Cell Apical/basal Polarity
Protein Localization To Cell Periphery
Regulation Of Early Endosome To Late Endosome Transport
Focal Adhesion
Extracellular Exosome
Associative Learning
Cell Periphery
Regulation Of Cell Morphogenesis
G Protein-coupled Dopamine Receptor Signaling Pathway
Cell-matrix Adhesion
Ruffle
Establishment Of Apical/basal Cell Polarity
Polarized Epithelial Cell Differentiation
Establishment Of Monopolar Cell Polarity
Establishment Or Maintenance Of Monopolar Cell Polarity
Negative Regulation Of Intracellular Signal Transduction
Cell-cell Adhesion
Acid Secretion
Microvillus Membrane
Gland Morphogenesis
Establishment Of Epithelial Cell Polarity
Localization Within Membrane
Positive Regulation Of Focal Adhesion Assembly
Cortical Actin Cytoskeleton Organization
Monocarboxylic Acid Transport
Regulation Of Vesicle-mediated Transport
Protein-membrane Adaptor Activity
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Tagcloud (Intersection)
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