MYOZ2 and ACTN4

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		MYOZ2	ACTN4
Gene Name		myozenin 2	actinin, alpha 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Actin Cytoskeleton Sarcomere Z Disc	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cell-cell Junction Focal Adhesion Z Disc Ribonucleoprotein Complex Cortical Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Neuron Projection Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding Protein Phosphatase 2B Binding Telethonin Binding	Nucleoside Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Nuclear Hormone Receptor Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Poly(A) RNA Binding Protein N-terminus Binding Actin Filament Binding
	Biological Process	Biological_process	Response To Hypoxia Platelet Degranulation Blood Coagulation Protein Transport Platelet Activation Positive Regulation Of Sodium:proton Antiporter Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Pinocytosis Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Positive Regulation Of Cellular Component Movement Tight Junction Assembly Protein Localization To Tight Junction Regulation Of Nucleic Acid-templated Transcription
Pathways			Response to elevated platelet cytosolic Ca2+ Nephrin interactions Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Heart rate ( 23583979)
Protein-Protein Interactions		12 interactors: ACTN1 ACTN2 ACTN4 DRICH1 EWSR1 FLNC LDB3 MYB PPP3CA PPP3CB RBPMS ZDHHC17	43 interactors: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 ESR1 GSN HDAC7 INO80 ITGB1 KPNA2 LRRC7 MAGI1 MAPK7 MEF2A MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTPN11 PTPN6 RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 STAT1 TJP1 TRIM3 TXN UCHL5 USP6NL VDR
Entrez ID		51778	81
HPRD ID		05724	05222
Ensembl ID		ENSG00000172399
Uniprot IDs		Q9NPC6	O43707
PDB IDs			1WLX 1YDI 2R0O
Enriched GO Terms of Interacting Partners?		Protein Localization To Tight Junction Cell Activation Cell Junction Assembly Calcineurin-NFAT Signaling Cascade Protein Localization To Cell Junction Platelet Degranulation Positive Regulation Of NFAT Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Transport Exocytosis Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Inositol Phosphate-mediated Signaling Actin Crosslink Formation Blood Coagulation Hemostasis Striated Muscle Cell Development Positive Regulation Of Intracellular Protein Transport Muscle Cell Development Regulation Of Protein Import Into Nucleus Secretion By Cell Platelet Activation Regulation Of Protein Localization To Nucleus Focal Adhesion Assembly Regulation Of Body Fluid Levels Cell-cell Junction Organization Regulation Of Nucleocytoplasmic Transport Wound Healing Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Striated Muscle Cell Differentiation Regulation Of RNA Metabolic Process Secretion Actin Filament-based Process Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Intracellular Transport Tight Junction Assembly Regulation Of Intracellular Protein Transport Response To Wounding Adherens Junction Assembly Muscle Fiber Development Positive Regulation Of Ion Transmembrane Transporter Activity Cell-substrate Junction Assembly Cellular Response To Drug Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transporter Activity Regulation Of Protein Localization Muscle Cell Differentiation Actin Filament Bundle Assembly Positive Regulation Of Protein Transport	Cellular Response To Organic Substance Response To Organic Substance Negative Regulation Of Signaling Response To Stress Developmental Process Cellular Response To Interferon-gamma Response To Interferon-gamma Negative Regulation Of Signal Transduction Regulation Of Cell Death Response To Abiotic Stimulus Defense Response Cellular Response To Lipid Regulation Of Signaling Regulation Of Apoptotic Process Signal Transduction Interferon-gamma-mediated Signaling Pathway Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Component Assembly Signaling Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cell Communication Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Innate Immune Response Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Response To Lipid Multicellular Organismal Development Response To Stimulus Regulation Of Cellular Component Organization Regulation Of Cellular Process Response To Hormone Abortive Mitotic Cell Cycle System Development Mitotic Cell Cycle Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipopolysaccharide
Tagcloud ?		actinin aligned bigenic calcineurin cardiomyopathy constituted disk disks flag gross hcm hemizygous hypertrophic hypertrophy i246m jnk54 lentiviral likewise luc mal myozenin nfatc pp2b ppp3cb quantifying rcan1 s48p transgene unsettled	1beta actin actinin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Difference) ?		aligned bigenic calcineurin cardiomyopathy constituted disk disks flag gross hcm hemizygous hypertrophic hypertrophy i246m jnk54 lentiviral likewise luc mal myozenin nfatc pp2b ppp3cb quantifying rcan1 s48p transgene unsettled	1beta actin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Intersection) ?		actinin