MYOZ2 and MYB

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MYOZ2	MYB
Description		myozenin 2	MYB proto-oncogene, transcription factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Actin Cytoskeleton Sarcomere Z Disc	Nucleus Nucleoplasm Cytosol Nuclear Matrix RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Actin Binding Protein Binding Protein Phosphatase 2B Binding Telethonin Binding FATZ Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding WD40-repeat Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Skeletal Muscle Fiber Adaptation Sarcomere Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Response To Hypoxia In Utero Embryonic Development Response To Ischemia Regulation Of DNA-templated Transcription Calcium Ion Transport Regulation Of Gene Expression Skeletal Muscle Cell Proliferation Stem Cell Division Myeloid Cell Differentiation B Cell Differentiation Erythrocyte Differentiation Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Neuron Apoptotic Process T-helper 2 Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Thymus Development Embryonic Digestive Tract Development Positive Regulation Of Smooth Muscle Cell Proliferation Homeostasis Of Number Of Cells Positive Regulation Of Glial Cell Proliferation Myeloid Cell Development Cellular Response To Hydrogen Peroxide Cellular Response To Retinoic Acid Cellular Response To Interleukin-6 Positive Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of MiRNA Transcription Positive Regulation Of Hepatic Stellate Cell Proliferation Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Hepatic Stellate Cell Activation Positive Regulation Of Testosterone Secretion
Pathways			RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production Specification of the neural plate border
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) PR interval ( 32439900) Refractive error ( 32231278)	Aspartate aminotransferase levels ( 33547301 33339817 29403010) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Beta thalassemia/hemoglobin E disease ( 20183929) Eosinophil count ( 29403010) Eosinophil percentage of white cells ( 32888494) Fetal hemoglobin levels in sickle cell anemia ( 25372704) Glycated hemoglobin levels ( 24647736 29483669 28898252) HbA2 levels ( 23043469) Hematocrit ( 19862010 29403010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010) Hemoglobin A1c levels ( 29403010) Hemoglobin levels ( 26366553) Hodgkin's lymphoma ( 24149102) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 19862010 29403010 28548082 28453575 28031487 19853236 20139978 23263863) Mean corpuscular hemoglobin concentration ( 29403010 23263863 20139978) Mean corpuscular volume ( 19853236 29403010 19862010 23263863 20139978 28031487 28453575) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 21833088) Myeloproliferative neoplasms ( 25849990) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Other erythrocyte phenotypes ( 19862010) Platelet count ( 29066854 24026423 33545615 26805783 28031487 22423221 19853236 22139419 20139978 29403010) Red blood cell count ( 29403010 28453575 28031487 20139978) Red blood cell traits ( 23935956 20927387) White blood cell count ( 29403010 20139978 32888494) White blood cell count (basophil) ( 27863252) White blood cell types ( 21738478)
Interacting Genes		18 interacting genes: ACTN1 ACTN2 ACTN4 CRK DRICH1 EWSR1 FLNC HSPB2 LDB3 MBLAC1 MKRN3 MYB PDLIM3 PPP3CA PPP3CB RBPMS WWOX ZDHHC17	49 interacting genes: BTRC CCND3 CEBPB CEBPE CHD3 CNOT9 CREBBP CSNK2A1 EP300 ERC2 FBXW2 FBXW5 FBXW7 H2AC4 H2BC3 H3-4 H3C1 H4C1 HIPK2 HLF KAT2A MAF MAPK1 MYBBP1A MYOZ2 NCL NCOR1 NLK PAIP1 PAX5 PIAS1 PML PPM1K RBX1 RPL4 SIN3A SKI SKP2 SMARCA2 SND1 SP100 SUMO1 SUMO2 TRIM28 TTF2 UBE2I UPF2 ZFHX3 ZMYND11
Entrez ID		51778	4602
HPRD ID		05724	01810
Ensembl ID		ENSG00000172399	ENSG00000118513
Uniprot IDs		Q9NPC6	P10242 Q708E9
PDB IDs
Enriched GO Terms of Interacting Partners?		Z Disc Cytoskeletal Protein Binding Muscle Cell Development Pseudopodium Actin Cytoskeleton Organization Actin Filament-based Process Actin Binding Cell Development Stress Fiber Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Transcription Coactivator Activity Actin Cytoskeleton Sarcomere Organization Calmodulin-dependent Protein Phosphatase Activity Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Cortical Actin Cytoskeleton Identical Protein Binding Positive Regulation Of Monoatomic Ion Transport Protein Serine/threonine Phosphatase Complex Platelet Alpha Granule Lumen Postsynaptic Actin Cytoskeleton Positive Regulation Of Calcium Ion Import Across Plasma Membrane Cytoskeleton Organization Enzyme Binding Actin Filament Binding Striated Muscle Cell Development Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Muscle Alpha-actinin Binding Regulation Of Monoatomic Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Calcineurin-NFAT Signaling Cascade Actomyosin Structure Organization Regulation Of Monoatomic Ion Transmembrane Transport Glutamatergic Synapse Positive Regulation Of Calcium Ion Import Positive Regulation Of RNA Metabolic Process Focal Adhesion Assembly Calcineurin-mediated Signaling Calcium Ion Binding Skeletal Muscle Fiber Development Filamentous Actin Transmembrane Transporter Binding Muscle Structure Development Regulation Of Metal Ion Transport	Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Nucleus PML Body Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process DNA Binding Chromatin Organization Regulation Of Primary Metabolic Process Rhythmic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process SUMO Transferase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Protein Sumoylation Histone H3K18 Acetyltransferase Activity Cellular Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Protein Stability Chromatin Ubiquitin Protein Ligase Binding DNA Damage Response Protein Modification Process Macromolecule Metabolic Process Signal Transduction By P53 Class Mediator SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
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