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CBLB and SORBS3
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
CBLB
SORBS3
Gene Name
Cbl proto-oncogene B, E3 ubiquitin protein ligase
sorbin and SH3 domain containing 3
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Nucleus
Cytosol
Cytoskeleton
Focal Adhesion
Molecular Function
Phosphotyrosine Binding
Ubiquitin-protein Transferase Activity
Signal Transducer Activity
Calcium Ion Binding
Protein Binding
Zinc Ion Binding
Ligase Activity
Structural Constituent Of Cytoskeleton
Protein Binding
Transcription Factor Binding
Vinculin Binding
Biological Process
Positive Regulation Of T Cell Anergy
NLS-bearing Protein Import Into Nucleus
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Protein Ubiquitination
Intracellular Signal Transduction
T Cell Activation
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Alpha-beta T Cell Proliferation
Negative Regulation Of T Cell Receptor Signaling Pathway
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Muscle Contraction
Actin Filament Organization
Cell Adhesion
Cell-substrate Adhesion
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cytoskeleton Organization
Positive Regulation Of Stress Fiber Assembly
Pathways
Signaling by the B Cell Receptor (BCR)
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Adaptive Immune System
Smooth Muscle Contraction
Drugs
Diseases
GWAS
Multiple sclerosis (
20453840
)
HIV-1 control (
20205591
)
Protein-Protein Interactions
32 interactors:
ARHGEF7
BLNK
CRKL
CRY1
EGFR
FLT3
FYB
FYN
GLRX3
GORASP2
GRB2
HNRNPK
KIT
NCK1
NCK2
NEDD4
PIK3R1
PLCG2
RET
RNF11
SH3KBP1
SHC1
SORBS3
SPRY2
SYK
TGFB1I1
TNFRSF11A
UBASH3B
UBC
VAV1
VAV2
ZAP70
46 interactors:
ABL1
ADAM15
ADAMTSL4
AKT1
ARNT2
CBLB
CPNE2
CPSF7
DDX17
DIP2A
DLG5
DMRTB1
DVL2
EFS
EIF3H
FAM154A
FASLG
FLOT1
HNRNPK
HNRNPUL1
INPPL1
KIAA0408
KIAA1217
MAPK1
MAPK3
NCKIPSD
NOTCH3
PAK1
PAK2
PAK7
RBMX
SAFB2
SH2D4A
SOCS7
SRCIN1
TBC1D22B
TRIM23
TRIM27
TRIM41
VARS2
VPS37B
VPS37C
ZBED1
ZBTB25
ZBTB7B
ZC4H2
Entrez ID
868
10174
HPRD ID
05136
11535
Ensembl ID
ENSG00000114423
ENSG00000120896
Uniprot IDs
B3KSS7
Q13191
O60504
PDB IDs
2AK5
2BZ8
2DO6
2J6F
2JNH
2LDR
2OOA
2OOB
3PFV
3VGO
3ZNI
2CT3
2DLM
2NWM
2YUP
Enriched GO Terms of Interacting Partners
?
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Activation
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Immune System Process
Immune Response-regulating Signaling Pathway
Fc Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Cell Migration
Locomotion
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Lymphocyte Activation
Immune Response
Signal Transduction
Cell Motility
Regulation Of ERBB Signaling Pathway
Cellular Response To Growth Factor Stimulus
Leukocyte Migration
Response To Growth Factor
Regulation Of Kinase Activity
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Leukocyte Activation
Signaling
Fibroblast Growth Factor Receptor Signaling Pathway
Cell Communication
Regulation Of Phosphorylation
Regulation Of Immune System Process
Single Organismal Cell-cell Adhesion
Regulation Of Immune Response
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Cell Adhesion
Regulation Of Phosphorus Metabolic Process
Antigen Receptor-mediated Signaling Pathway
Movement Of Cell Or Subcellular Component
Innate Immune Response
Response To Organic Substance
Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc-gamma Receptor Signaling Pathway
Gene Expression
Regulation Of Cellular Amino Acid Metabolic Process
Transcription, DNA-templated
Regulation Of Cellular Ketone Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
RNA Biosynthetic Process
Regulation Of Metabolic Process
Fc Receptor Signaling Pathway
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Regulation Of Cellular Process
Negative Regulation Of Protein Kinase Activity
Intracellular Signal Transduction
Negative Regulation Of Kinase Activity
Regulation Of Protein Metabolic Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
RNA Metabolic Process
Regulation Of Protein Tyrosine Kinase Activity
Biosynthetic Process
Regulation Of Gene Expression
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc-gamma Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Innate Immune Response
Response To Insulin
Immune Response
Regulation Of Protein Phosphorylation
Negative Regulation Of Transferase Activity
Response To Epidermal Growth Factor
Immune Response-regulating Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Regulation Of Golgi Inheritance
Negative Regulation Of Protein Phosphorylation
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Caveolin-mediated Endocytosis
Cellular Response To Insulin Stimulus
Cell Morphogenesis Involved In Differentiation
Protein Autophosphorylation
Positive Regulation Of Protein Phosphorylation
Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Protein Tyrosine Kinase Activity
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Phosphorus Metabolic Process
Tagcloud
?
calm3
ccna2
ccnd3
cdk6
cited1
dems
dok
elk3
fyn
git1
hck
lck
module
modules
nonmodule
p85beta
pdgfra
pib5pa
psd93
ptch2
sam68
sh3kbp1
shc
tgfbr1
tgfbr2
vav2
wilcoxon
yes
zfyve9
Tagcloud (Difference)
?
calm3
ccna2
ccnd3
cdk6
cited1
dems
dok
elk3
fyn
git1
hck
lck
module
modules
nonmodule
p85beta
pdgfra
pib5pa
psd93
ptch2
sam68
sh3kbp1
shc
tgfbr1
tgfbr2
vav2
wilcoxon
yes
zfyve9
Tagcloud (Intersection)
?