CBLB and TGFB1I1

Number of citations of the paper that reports this interaction (PMID 23145173)
1

Data Source:
BioGRID (two hybrid)

		CBLB	TGFB1I1
Gene Name		Cbl proto-oncogene B, E3 ubiquitin protein ligase	transforming growth factor beta 1 induced transcript 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Intracellular Cytoplasm Cytoskeleton Focal Adhesion Nuclear Matrix Extracellular Matrix
	Molecular Function	Phosphotyrosine Binding Ubiquitin-protein Transferase Activity Signal Transducer Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Ligase Activity	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Roundabout Binding Androgen Receptor Binding I-SMAD Binding
	Biological Process	Positive Regulation Of T Cell Anergy NLS-bearing Protein Import Into Nucleus Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Protein Ubiquitination Intracellular Signal Transduction T Cell Activation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Alpha-beta T Cell Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway	Transcription From RNA Polymerase II Promoter Cell Adhesion Negative Regulation Of Cell Proliferation Response To Heat Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Morphogenesis Of Embryonic Epithelium Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Epithelial Cell Differentiation Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways		Signaling by the B Cell Receptor (BCR) Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
Drugs
Diseases
GWAS		Multiple sclerosis ( 20453840)
Protein-Protein Interactions		32 interactors: ARHGEF7 BLNK CRKL CRY1 EGFR FLT3 FYB FYN GLRX3 GORASP2 GRB2 HNRNPK KIT NCK1 NCK2 NEDD4 PIK3R1 PLCG2 RET RNF11 SH3KBP1 SHC1 SORBS3 SPRY2 SYK TGFB1I1 TNFRSF11A UBASH3B UBC VAV1 VAV2 ZAP70	29 interactors: AR CBLB CBLC CDKN2B CRKL CSK EP300 FKBP1A GIT1 GIT2 GP1BB HIPK3 HSPB1 ITGA4 MAPK15 NEDD4L NR3C1 PLA2G3 PTK2 PTK2B PTPN12 SDC4 SLC6A3 SMAD7 SVIL TGFBR2 TRAF4 UBQLN4 VCL
Entrez ID		868	7041
HPRD ID		05136	03831
Ensembl ID		ENSG00000114423	ENSG00000140682
Uniprot IDs		B3KSS7 Q13191	O43294
PDB IDs		2AK5 2BZ8 2DO6 2J6F 2JNH 2LDR 2OOA 2OOB 3PFV 3VGO 3ZNI
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cell Migration Locomotion Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Lymphocyte Activation Immune Response Signal Transduction Cell Motility Regulation Of ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Leukocyte Migration Response To Growth Factor Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Leukocyte Activation Signaling Fibroblast Growth Factor Receptor Signaling Pathway Cell Communication Regulation Of Phosphorylation Regulation Of Immune System Process Single Organismal Cell-cell Adhesion Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cell Adhesion Regulation Of Phosphorus Metabolic Process Antigen Receptor-mediated Signaling Pathway Movement Of Cell Or Subcellular Component Innate Immune Response Response To Organic Substance Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway	Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Cell Activation Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Signaling Cell Communication Signal Transduction Response To Stimulus Regulation Of Catalytic Activity Transforming Growth Factor Beta Receptor Signaling Pathway Response To Organic Substance Organ Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Modification Process Cellular Response To Organic Substance Cellular Response To Transforming Growth Factor Beta Stimulus Cell Surface Receptor Signaling Pathway System Development Response To Transforming Growth Factor Beta Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Anatomical Structure Development Regulation Of Protein Catabolic Process Negative Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Negative Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Phosphorylation Response To Organic Cyclic Compound Negative Regulation Of Signaling Cellular Response To Stimulus Multicellular Organismal Development Regulation Of Cellular Process Positive Regulation Of Protein Kinase Activity Developmental Process Positive Regulation Of Kinase Activity Negative Regulation Of Transferase Activity Positive Regulation Of Protein Phosphorylation
Tagcloud ?		calm3 ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9	aii aiii aiiis aiis astrocytoma astrocytomas beta1 bioinformatics biomarker contributing emt focused grade grades idh1 integration malignant microarrays multistep nbt progress progression qpcr shrna tp53 transcript transition validated
Tagcloud (Difference) ?		calm3 ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9	aii aiii aiiis aiis astrocytoma astrocytomas beta1 bioinformatics biomarker contributing emt focused grade grades idh1 integration malignant microarrays multistep nbt progress progression qpcr shrna tp53 transcript transition validated
Tagcloud (Intersection) ?