PKIA

Gene Name		protein kinase (cAMP-dependent, catalytic) inhibitor alpha
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Multiple sclerosis ( 21833088) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-protein Interactions		8 interactors: AGFG1 DYNLL1 EGFR JUNB PRKACA PRKACB PRKX XPO1
Entrez ID		5569
HPRD ID		05828
Ensembl ID		ENSG00000171033
Uniprot IDs		P61925
PDB IDs		1CMK 1JLU 1Q8T 1VEB 1XH4 1XH5 1XH6 1XH7 1XH8 1XH9 1XHA 1YDR 2C1A 2C1B 2F7E 2GNI 2JDS 2JDT 2JDV 2L1L 2UVX 2UVY 2UVZ 2UW0 2UW3 2UW4 2UW5 2UW6 2UW7 2UW8 2VNW 2VNY 2VO0 2VO3 2VO6 2VO7 3AMA 3AMB 3L9L 3L9M 3L9N 3MVJ 3NX8 3OOG 3OVV 3OWP 3OXT 3P0M 3POO 3VQH 4AXA 4IAC 4IAD 4IAF 4IAI 4IAK 4IAY 4IAZ 4IE9 4IJ9
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Activation Of Phospholipase C Activity Response To Growth Factor Positive Regulation Of Phospholipase C Activity Anatomical Structure Morphogenesis Regulation Of Establishment Of Protein Localization Positive Regulation Of Phospholipase Activity Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of Protein Localization Multicellular Organismal Reproductive Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Multicellular Organism Reproduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Tube Morphogenesis Regulation Of Intracellular Transport Regulation Of Cellular Localization Reproduction Anatomical Structure Formation Involved In Morphogenesis Activation Of Protein Kinase A Activity Morphogenesis Of An Epithelium Immune System Process Single Organism Reproductive Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Triglyceride Catabolic Process Cellular Response To Hormone Stimulus Reproductive Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Protein Export From Nucleus Regulation Of Protein Transport Acylglycerol Catabolic Process Regulation Of Nucleocytoplasmic Transport Tissue Morphogenesis Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Renal Water Homeostasis Negative Regulation Of Embryonic Development Neurotrophin Signaling Pathway Tube Development Negative Regulation Of Smoothened Signaling Pathway Developmental Process Involved In Reproduction Positive Regulation Of Intracellular Transport Regulation Of Signal Transduction Mitotic Cell Cycle Regulation Of Intracellular Protein Transport Mitotic Cell Cycle Phase Transition
Tagcloud ?		acetaminophen alanine apap attenuation comparing corroborated determining differently discover dismutase exacerbation forty glutathione grouped hepatotoxicity peroxidase peroxynitrite pka potentiated pretreatment reflecting screen serious severity sought substantial superoxide susceptible transaminase