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PKIA and DYNLL2
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
PKIA
DYNLL2
Description
cAMP-dependent protein kinase inhibitor alpha
dynein light chain LC8-type 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Nucleus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Cytoplasmic Dynein Complex
Microtubule
Microtubule Associated Complex
Plasma Membrane
Cilium
Postsynaptic Density
Microtubule Cytoskeleton
Membrane
Dynein Complex
Myosin V Complex
Ciliary Tip
9+0 Non-motile Cilium
Postsynapse
Glutamatergic Synapse
Molecular Function
Protein Kinase Inhibitor Activity
CAMP-dependent Protein Kinase Inhibitor Activity
Protein Binding
Protein Kinase A Catalytic Subunit Binding
Protein Binding
Identical Protein Binding
Protein-containing Complex Binding
Dynein Intermediate Chain Binding
Scaffold Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of CAMP/PKA Signal Transduction
Negative Regulation Of CAMP-dependent Protein Kinase Activity
Microtubule-based Process
Pathways
Activation of BMF and translocation to mitochondria
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Macroautophagy
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Intraflagellar transport
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
HCMV Early Events
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Drugs
3,5-Diiodotyrosine
Hydroxyfasudil
(2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamine
(1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE
(1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE
(4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE
N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
(S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE
(2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
(2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
(2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
H-89
5-(2-methylpiperazine-1-sulfonyl)isoquinoline
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
3-pyridin-4-yl-1H-indazole
5-benzyl-1,3-thiazol-2-amine
1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium
Fasudil
Myristic acid
A-674563
3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE
Y-27632
Diseases
GWAS
Femoral neck bone mineral density (
22504420
)
Intraocular pressure (
29617998
31959993
)
Multiple sclerosis (
21833088
)
Optic disc size (
31809533
)
Systemic lupus erythematosus (
28714469
)
Systolic blood pressure response to hydrochlorothiazide in hypertension (
27802415
)
Blood protein levels (
30072576
)
Interacting Genes
12 interacting genes:
AGFG1
CASP6
DYNLL1
DYNLL2
EGFR
JUNB
MRNIP
PRC1
PRKACA
PRKACB
PRKX
XPO1
30 interacting genes:
BMF
C14orf119
DLGAP1
DNAL4
DPPA3
DYNC1I1
EWSR1
FAM117B
GABARAPL2
GPHN
GPRIN2
HDAC6
HOMER3
IHO1
MEOX2
MORN3
MYO5A
OTUD6A
PAK1
PKIA
PKIG
RASGRP3
REDIC1
SKAP1
SMCP
SPAG8
THAP10
TPPP
XIAP
ZAR1
Entrez ID
5569
140735
HPRD ID
05828
06489
Ensembl ID
ENSG00000171033
ENSG00000264364
Uniprot IDs
P61925
Q96FJ2
PDB IDs
1CMK
1JLU
1Q8T
1VEB
1XH4
1XH5
1XH6
1XH7
1XH8
1XH9
1XHA
1YDR
2C1A
2C1B
2F7E
2GNI
2JDS
2JDT
2JDV
2L1L
2UVX
2UVY
2UVZ
2UW0
2UW3
2UW4
2UW5
2UW6
2UW7
2UW8
2VNW
2VNY
2VO0
2VO3
2VO6
2VO7
3AMA
3AMB
3L9L
3L9M
3L9N
3MVJ
3NX8
3OOG
3OVV
3OWP
3OXT
3P0M
3POO
3VQH
3WYG
3X2U
3X2V
3X2W
4AXA
4IAC
4IAD
4IAF
4IAI
4IAK
4IAY
4IAZ
4IB0
4IB1
4IB3
4IE9
4IJ9
4O21
4O22
4UJ1
4UJ2
4UJ9
4UJA
4UJB
4WB5
4WB6
4WB7
4WB8
4Z83
4Z84
5BX6
5BX7
5DH9
5LCP
5LCQ
5LCR
5LCT
5LCU
5M0B
5M0C
5M0L
5M0U
5M6V
5M6Y
5M71
5M75
5N23
5XOJ
6E21
6E99
6E9L
6FRX
6QJ7
6X2U
6X2V
6X2W
7UJX
7V0G
8FE2
8FE5
8FEC
2XQQ
3P8M
4D07
7CNU
Enriched GO Terms of Interacting Partners
?
CAMP-dependent Protein Kinase Activity
CAMP-dependent Protein Kinase Complex
Nucleus
High-density Lipoprotein Particle Assembly
Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
Regulation Of Cell Cycle
Vascular Endothelial Cell Response To Fluid Shear Stress
Cellular Response To Laminar Fluid Shear Stress
Renal Water Homeostasis
Nuclear Export
Response To Laminar Fluid Shear Stress
Plasma Lipoprotein Particle Assembly
Cytoplasmic Dynein Complex
Protein-lipid Complex Assembly
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Multicellular Organismal-level Water Homeostasis
Cytosol
Protein Kinase Activity
Cellular Response To Fluid Shear Stress
Regulation Of Protein Export From Nucleus
Protein Export From Nucleus
Negative Regulation Of Smoothened Signaling Pathway
Dynein Intermediate Chain Binding
Dynein Complex
Microtubule Associated Complex
Regulation Of Cellular Localization
Ciliary Base
Peptidyl-serine Phosphorylation
Response To Fluid Shear Stress
Regulation Of Phosphorus Metabolic Process
Cilium
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Ciliary Tip
Intracellular Signal Transduction
Kinase Activity
Multivesicular Body, Internal Vesicle Lumen
Nuclear Transport
Nucleocytoplasmic Transport
Microtubule Cytoskeleton
Myosin V Complex
Regulation Of Protein Processing
Regulation Of Intracellular Transport
Centrosome
Regulation Of Protein Maturation
TORC1 Signaling
Negative Regulation Of TORC1 Signaling
MRNA Export From Nucleus
Ubiquitin Protein Ligase Binding
Multicellular Organismal-level Chemical Homeostasis
Scaffold Protein Binding
Microtubule Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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