PKIA and PRKX

Number of citations of the paper that reports this interaction (PubMedID 10026146)
0

Data Source:
HPRD (in vitro)

		PKIA	PRKX
Description		cAMP-dependent protein kinase inhibitor alpha	protein kinase cAMP-dependent X-linked catalytic subunit
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol CAMP-dependent Protein Kinase Complex
	Molecular Function	Protein Kinase Inhibitor Activity CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding Protein Kinase A Catalytic Subunit Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of CAMP-dependent Protein Kinase Activity	Angiogenesis Endothelial Cell Proliferation Cell Adhesion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Peptidyl-serine Phosphorylation Myeloid Cell Differentiation Cell Differentiation Regulation Of Cell Adhesion Regulation Of Cell Migration Cell-substrate Adhesion Endothelial Cell Migration Protein Autophosphorylation Epithelial Tube Morphogenesis Kidney Morphogenesis Regulation Of Epithelial Cell Differentiation Involved In Kidney Development
Pathways			PKA-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of Adenylate Cyclase ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
Drugs		3,5-Diiodotyrosine Hydroxyfasudil (2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamine (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE 6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE (2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine (2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE H-89 5-(2-methylpiperazine-1-sulfonyl)isoquinoline N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE 3-pyridin-4-yl-1H-indazole 5-benzyl-1,3-thiazol-2-amine 1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine 1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium Fasudil Myristic acid A-674563 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE Y-27632
Diseases
GWAS		Femoral neck bone mineral density ( 22504420) Intraocular pressure ( 29617998 31959993) Multiple sclerosis ( 21833088) Optic disc size ( 31809533) Systemic lupus erythematosus ( 28714469) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)	Lymphocyte count ( 29403010) Thyroid stimulating hormone levels ( 30367059)
Interacting Genes		12 interacting genes: AGFG1 CASP6 DYNLL1 DYNLL2 EGFR JUNB MRNIP PRC1 PRKACA PRKACB PRKX XPO1	5 interacting genes: NEDD4 NEDD4L PKIA PRKAR1A PRKAR2A
Entrez ID		5569	5613
HPRD ID		05828	02097
Ensembl ID		ENSG00000171033	ENSG00000183943
Uniprot IDs		P61925	P51817
PDB IDs		1CMK 1JLU 1Q8T 1VEB 1XH4 1XH5 1XH6 1XH7 1XH8 1XH9 1XHA 1YDR 2C1A 2C1B 2F7E 2GNI 2JDS 2JDT 2JDV 2L1L 2UVX 2UVY 2UVZ 2UW0 2UW3 2UW4 2UW5 2UW6 2UW7 2UW8 2VNW 2VNY 2VO0 2VO3 2VO6 2VO7 3AMA 3AMB 3L9L 3L9M 3L9N 3MVJ 3NX8 3OOG 3OVV 3OWP 3OXT 3P0M 3POO 3VQH 3WYG 3X2U 3X2V 3X2W 4AXA 4IAC 4IAD 4IAF 4IAI 4IAK 4IAY 4IAZ 4IB0 4IB1 4IB3 4IE9 4IJ9 4O21 4O22 4UJ1 4UJ2 4UJ9 4UJA 4UJB 4WB5 4WB6 4WB7 4WB8 4Z83 4Z84 5BX6 5BX7 5DH9 5LCP 5LCQ 5LCR 5LCT 5LCU 5M0B 5M0C 5M0L 5M0U 5M6V 5M6Y 5M71 5M75 5N23 5XOJ 6E21 6E99 6E9L 6FRX 6QJ7 6X2U 6X2V 6X2W 7UJX 7V0G 8FE2 8FE5 8FEC
Enriched GO Terms of Interacting Partners?		CAMP-dependent Protein Kinase Activity CAMP-dependent Protein Kinase Complex Nucleus High-density Lipoprotein Particle Assembly Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Cell Cycle Vascular Endothelial Cell Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Renal Water Homeostasis Nuclear Export Response To Laminar Fluid Shear Stress Plasma Lipoprotein Particle Assembly Cytoplasmic Dynein Complex Protein-lipid Complex Assembly Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Multicellular Organismal-level Water Homeostasis Cytosol Protein Kinase Activity Cellular Response To Fluid Shear Stress Regulation Of Protein Export From Nucleus Protein Export From Nucleus Negative Regulation Of Smoothened Signaling Pathway Dynein Intermediate Chain Binding Dynein Complex Microtubule Associated Complex Regulation Of Cellular Localization Ciliary Base Peptidyl-serine Phosphorylation Response To Fluid Shear Stress Regulation Of Phosphorus Metabolic Process Cilium Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Ciliary Tip Intracellular Signal Transduction Kinase Activity Multivesicular Body, Internal Vesicle Lumen Nuclear Transport Nucleocytoplasmic Transport Microtubule Cytoskeleton Myosin V Complex Regulation Of Protein Processing Regulation Of Intracellular Transport Centrosome Regulation Of Protein Maturation TORC1 Signaling Negative Regulation Of TORC1 Signaling MRNA Export From Nucleus Ubiquitin Protein Ligase Binding Multicellular Organismal-level Chemical Homeostasis Scaffold Protein Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Kinase A Catalytic Subunit Binding Negative Regulation Of CAMP/PKA Signal Transduction Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Potassium Ion Export Across Plasma Membrane CAMP-dependent Protein Kinase Regulator Activity Sodium Channel Inhibitor Activity Potassium Channel Inhibitor Activity CAMP-dependent Protein Kinase Complex Nucleotide-activated Protein Kinase Complex Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Receptor Catabolic Process CAMP Binding Negative Regulation Of Potassium Ion Transmembrane Transport Protein Domain Specific Binding Negative Regulation Of Potassium Ion Transport Plasma Membrane Raft Neuromuscular Junction Development Ciliary Base Receptor Metabolic Process Multivesicular Body Protein Monoubiquitination Regulation Of Dendrite Morphogenesis Negative Regulation Of Transport Regulation Of Potassium Ion Transmembrane Transport Receptor Internalization Negative Regulation Of Cation Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Signal Transduction Regulation Of Potassium Ion Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Formation Of Structure Involved In A Symbiotic Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of Dendrite Development Regulation Of Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Regulation Of Nucleocytoplasmic Transport Axoneme Channel Inhibitor Activity Transmembrane Transporter Binding Regulation Of Intracellular Signal Transduction Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phosphothreonine Residue Binding Negative Regulation Of Sodium Ion Import Across Plasma Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?