PKIA and PRKX

Number of citations of the paper that reports this interaction (PMID 10026146)
19

Data Source:
HPRD (in vitro)

		PKIA	PRKX
Gene Name		protein kinase (cAMP-dependent, catalytic) inhibitor alpha	protein kinase, X-linked
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding Protein Kinase A Catalytic Subunit Binding	CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of CAMP-dependent Protein Kinase Activity	Angiogenesis Endothelial Cell Proliferation Cell Adhesion Peptidyl-serine Phosphorylation Myeloid Cell Differentiation Regulation Of Cell Adhesion Regulation Of Cell Migration Cell-substrate Adhesion Endothelial Cell Migration Protein Autophosphorylation Epithelial Tube Morphogenesis Kidney Morphogenesis Regulation Of Epithelial Cell Differentiation Involved In Kidney Development
Pathways
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Multiple sclerosis ( 21833088) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		8 interactors: AGFG1 DYNLL1 EGFR JUNB PRKACA PRKACB PRKX XPO1	5 interactors: NEDD4 NEDD4L PKIA PRKAR1A PRKAR2A
Entrez ID		5569	5613
HPRD ID		05828	02097
Ensembl ID		ENSG00000171033	ENSG00000183943
Uniprot IDs		P61925	P51817
PDB IDs		1CMK 1JLU 1Q8T 1VEB 1XH4 1XH5 1XH6 1XH7 1XH8 1XH9 1XHA 1YDR 2C1A 2C1B 2F7E 2GNI 2JDS 2JDT 2JDV 2L1L 2UVX 2UVY 2UVZ 2UW0 2UW3 2UW4 2UW5 2UW6 2UW7 2UW8 2VNW 2VNY 2VO0 2VO3 2VO6 2VO7 3AMA 3AMB 3L9L 3L9M 3L9N 3MVJ 3NX8 3OOG 3OVV 3OWP 3OXT 3P0M 3POO 3VQH 4AXA 4IAC 4IAD 4IAF 4IAI 4IAK 4IAY 4IAZ 4IE9 4IJ9
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Activation Of Phospholipase C Activity Response To Growth Factor Positive Regulation Of Phospholipase C Activity Anatomical Structure Morphogenesis Regulation Of Establishment Of Protein Localization Positive Regulation Of Phospholipase Activity Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of Protein Localization Multicellular Organismal Reproductive Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Multicellular Organism Reproduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Tube Morphogenesis Regulation Of Intracellular Transport Regulation Of Cellular Localization Reproduction Anatomical Structure Formation Involved In Morphogenesis Activation Of Protein Kinase A Activity Morphogenesis Of An Epithelium Immune System Process Single Organism Reproductive Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Triglyceride Catabolic Process Cellular Response To Hormone Stimulus Reproductive Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Protein Export From Nucleus Regulation Of Protein Transport Acylglycerol Catabolic Process Regulation Of Nucleocytoplasmic Transport Tissue Morphogenesis Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Renal Water Homeostasis Negative Regulation Of Embryonic Development Neurotrophin Signaling Pathway Tube Development Negative Regulation Of Smoothened Signaling Pathway Developmental Process Involved In Reproduction Positive Regulation Of Intracellular Transport Regulation Of Signal Transduction Mitotic Cell Cycle Regulation Of Intracellular Protein Transport Mitotic Cell Cycle Phase Transition	Negative Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of CAMP-dependent Protein Kinase Activity Water Homeostasis Regulation Of Cellular Localization Negative Regulation Of Sodium Ion Transport Negative Regulation Of Protein Serine/threonine Kinase Activity Activation Of Protein Kinase A Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Localization Negative Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Kinase Activity Regulation Of Potassium Ion Transmembrane Transporter Activity Renal Water Homeostasis Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Potassium Ion Transmembrane Transport Cellular Response To Glucagon Stimulus Protein Monoubiquitination Water Transport Positive Regulation Of Protein Metabolic Process Fluid Transport Negative Regulation Of Phosphorylation Activation Of Phospholipase C Activity Multicellular Organismal Water Homeostasis Negative Regulation Of Transport Response To Glucagon Positive Regulation Of Phospholipase C Activity Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Potassium Ion Transport Regulation Of Sodium Ion Transport Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Ion Transport Renal System Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Transport Cellular Response To Organic Substance Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Regulation Of Establishment Of Protein Localization Regulation Of Protein Kinase Activity Energy Reserve Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		acetaminophen alanine apap attenuation comparing corroborated determining differently discover dismutase exacerbation forty glutathione grouped hepatotoxicity peroxidase peroxynitrite pka potentiated pretreatment reflecting screen serious severity sought substantial superoxide susceptible transaminase	c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic rac3 ripk4 snf1lk sod1 tbl1x
Tagcloud (Difference) ?		acetaminophen alanine apap attenuation comparing corroborated determining differently discover dismutase exacerbation forty glutathione grouped hepatotoxicity peroxidase peroxynitrite pka potentiated pretreatment reflecting screen serious severity sought substantial superoxide susceptible transaminase	c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic rac3 ripk4 snf1lk sod1 tbl1x
Tagcloud (Intersection) ?